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    Association between tumor markers (CA125, CA15-3) and homozygous sickle cell anemia
    (Bayrakol Medical Publisher, 2022) Kavvasoglu, Gamze Hande; Kavvasoglu, Baris; Kaya, Hasan
    Aim: Sickle Cell Anemia (SCA) is a systemic and chronic inflammatory disease and is one of the most common hemoglobinopathies in the world and in our country. Cancer antigen 15-3 (CA15-3) and cancer antigen (CA125) have an important place in cancer screening, treatment follow-up and disease follow-up today. However, it has been shown that it may be high in some diseases other than these purposes. In this study, we also planned to determine the relationship between tumor markers and patients with SCA, which is a chronic inflammatory and ischemic disease. Material and Methods: Patients over the age of 18 who were diagnosed with homozygous SCA and followed up in the Department of Internal Diseases of Hatay Mustafa Kemal University Health Practice and Research Hospital and applied to the outpatient clinic were included in the study. Height, weight, body mass index (BMI) and waist circumference of all patients were measured. Echocardiographic examination was performed. Blood samples were collected from the patients to study CA125 and CA15-3 on appropriate days and conditions. Results: A total of 34 patients, 19 female and 15 male, and 35 healthy volunteers, 16 female and 19 male, were included in the study. In the echocardiographic examinations, the ejection fraction was normal in the control and SCA groups, and no signs of pericardial effusion were found. The mean CA15-3 of the patients with SCA was 56.42 +/- 23.73 U/ml, the mean of CA15-3 of the control group was 9.99 +/- 4.62 U/ml, and there was a statistically significant difference (p=0,001). The median CA125 value of patients with SCA was calculated as 5.95 U/ml, while the highest was 99 U/ml and the lowest was 1.8 U/ml. While the median CA125 value of the control group was calculated as 6 U/ml, the highest measurement was 17.8 U/ml and the lowest measurement was 0.7 U/ml. There was no any statistically significant difference between the groups. Discussion: Although the CA15-3 level was high in patients with SCA, the CA125 level was normal. We think that CA15-3 level is important in understanding the pathophysiology and mechanism of SCA and in terms of follow-up. Our study should be supported by studies with large patient participation.
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    Correlations between the Maximum Standard Uptake Value of Positron Emission Tomography/Computed Tomography and Laboratory Parameters before and after Treatment in Patients with Lymphoma
    (Wolters Kluwer Medknow Publications, 2018) Ucar, Edip; Yalcin, Hulya; Kavvasoglu, Gamze Hande; Ilhan, Gul
    Background: After the first examination of patients with lymphoma diagnosis, important laboratory tests such as complete blood count; albumin, kidney and liver function tests; uric acid; beta 2-microglobulin; C-reactive protein (CRP); erythrocyte sedimentation rate (ESR); and lactate dehydrogenase (LDH) examinations are recommended. In this study, our aim was to find the relationship between laboratory parameters and the maximum standard uptake value (SUVmax) of positron emission tomography/computed tomography (PET/CT) in patients with lymphoma at the diagnosis and after treatment. Methods: Thirty-four lymphoma patients treated at Mustafa Kemal University Internal Medicine Clinic between 2014 and 2017 were included in this retrospective study. Results of CRP, ESR, LDH, albumin, and white blood cell (WBC) count were recorded before each PET scan test, and each parameter was analyzed for correlation with SUVmax measurements. Results: Spearman's correlation test showed that the after-treatment SUVmax values were significantly correlated with the after-treatment LDH, ESR, and CRP values (for LDH, ESR, and CRP, R-2: 0.453, 0.426, and 0.351; P = 0.007, 0.012, and 0.042, respectively). On the other hand, albumin and WBC count did not show a significant correlation with the after-treatment SUVmax values (all P > 0.05). Conclusions: CRP, ESR, and LDH values may also be good predictors in patients for whom PET/CT imaging cannot be performed.