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    The Response of Japanese Quails to Dietary Thymbra spicata L. Essential Oil
    (Ars Docendi, 2018) Aksu, Taylan; Aksu, Devrim S.; Kaya, Durmus A.; Duran, Nizami; Onel, Suleyman E.; Canogullari, Sibel
    In the present study, the response of Japanese Quails to dietary Thymbra spicata L. essential oil was investigated. A total of 192 Japanese quail chicks, 1-day old and of mixed sexes, were used in the feeding trial. Birds were randomly allocated to four dietary treatments comprising three experimental groups and one control group (basal diet). Each group was divided into four subgroups, with each containing twelve chicks. EO was added daily to the basal diet at levels of 200 (T1), 400 (T2) and 600 mg/kg (T3), respectively. There was a significantly increase in live weight at 35 days when quails were supplemented with increasing level of EO. Moreover, live weight gain significantly increased over ranges of 28-35 and 0-35 days in quails fed the EO at 600 mg/kg level compared to the control group (P<0.05). No differences were observed among treatments for feed intake. A significantly improvement in feed efficiency at 28-35 days (P<0.001) was observed in treated groups. Treatments significantly decreased the number of total bacteria and Escherichia coli in the small intestine. A significantly decrease was observed for TG levels in all treatment groups. TG/TC rate was significantly decreased in supplemented groups (P<0.001). Treatments did not alter serum HDL and LDL levels. In conclusion, dietary T. spicata L. EO enhanced the performance parameters by showing time-depended effects. This property could be important to recommend the implementation time of such compounds to the poultry diets.
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    SPONGIOUS FILLERS BASED ON COLLAGEN - HYDROXYAPATITE - EUGENOL ACETATE WITH THERAPEUTIC POTENTIAL IN BONE CANCER
    (Soc Stiinte Farmaceutice Romania, 2020) Vladu, Alina F.; Marin, Stefania; Neacsu, Ionela A.; Trusca, Roxana D.; Kaya, Madalina G. Albu; Kaya, Durmus A.; Popa, Ana-Maria
    The aim of this study was to develop and characterize composite materials based on collagen, hydroxyapatite and eugenol acetate as new filler biomaterial for the reconstruction of the tissue damage arising after the resection in case of bone cancer. Composite gels consisting of collagen and hydroxyapatite in different proportions (Coll:HAp - 100:0; 70:30; 40:60 - w/w) and 0.5% eugenol acetate were lyophilized and spongious fillers were obtained. The fillers were characterized by water absorption, enzymatic degradation and examined by optical and scanning electron microscopy, EDS, FT-IR spectroscopy while eugenol acetate release from the compositions was also studied. The results showed that the filler with optimal composition (Coll-HAp - 40:60 w/w) completely degrade over about 48 hours, the release capacity being longer during the 144 hours. The complex results obtained from physical-chemical, morphological and eugenol acetate release profile evaluation for the designed composite materials based on collagen and hydroxyapatite testify these formulations as drug delivery systems with potential applications as fillers in orthopaedic field in bone cancer.