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Öğe Ala-9Val polymorphism of Mn-SOD gene in sickle cell anemia(Funpec-Editora, 2011) Sogut, S.; Yonden, Z.; Kaya, H.; Oktar, S.; Tutanc, M.; Yilmaz, H. R.; Yigit, A.Oxidative stress may be contributory to the pathophysiology of the abnormalities that underlie the clinical course of sickle cell anemia. We looked for a possible genetic association between the functional polymorphism Ala-9Val in the human Mn-SOD gene and sickle cell anemia. One hundred and twenty-seven patients with sickle cell anemia and 127 healthy controls were recruited into the study. Alanine versus valine polymorphism in the signal peptide of the Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with the restriction enzyme NgoMIV. In the sickle cell anemia patients, the frequency of Val/Val genotype was approximately 1.4-fold lower and that of Ala/Val was 1.3-fold higher compared to the controls. No significant difference in genotype frequencies was found between patients and controls (chi(2) = 4.561, d.f. = 2, P = 0.101). The Val-9 was the most common allele in patient and healthy subjects. No significant difference in allele frequencies was found between patients and controls (chi(2) = 1.496, d.f. = 1, P = 0.221). We conclude that the Mn-SOD gene polymorphism is not associated with sickle cell anemia.Öğe Association of left ventricular diastolic function abnormalities with aortic elastic properties in asymptomatic patients with type 2 diabetes mellitus. A tissue doppler echocardiographic study(Wiley, 2008) Seyfeli, E.; Duru, M.; Saglam, H.; Akgul, F.; Kuvandik, G.; Kaya, H.; Yalcin, F.Background: The aim of this study was to investigate the association between the aortic elastic properties and the left ventricular diastolic function measured by tissue Doppler echocardiography (TDE) in asymptomatic type 2 diabetes mellitus. Methods: Fifty-seven asymptomatic patients with type 2 diabetes (33 women, mean age: 49 +/- 6 years) and 25 healthy control subjects (19 women, mean age: 46 +/- 7 years) were included in the present study. Diastolic filling indices were measured by conventional (CE) and tissue Doppler echocardiography. The aortic elastic properties [Aortic stiffness index (ASI), aortic distensibility and strain] were measured as previous definition. Results: Compared with control subjects, the ratio of LV diastolic abnormalities measured by CE and TDE were found higher in patients with type 2 diabetes (36% and 73.6%, p = 0.001, respectively, and 52% and 89.4%, p < 0.001, for septal annulus; 48% and 89.4%, p < 0.001 for septal basal respectively). The ASI was significantly higher (p < 0.001), aortic distensibility and aortic strain were also significantly lower in patients with type 2 diabetes than control subjects (p < 0.001 and p < 0.001 respectively). In the regression analysis, Ao distensibility was correlated to age (beta = -0.299, p = 0.004), septal basal Em/Am ratio (beta =0.543, p < 0.001) and HDL-cholesterol (beta = 0.192, p = 0.039). ASI was also correlated only to age (beta = 0.255, p = 0.044), the presence of diabetes mellitus (beta = 0.304, p = 0.009), mitral A wave (beta = 0.322, p = 0.013) and mitral annulus Em wave (beta = -0.505, p < 0.001). Conclusion: The aortic elastic function is impaired in asymptomatic patients with type 2 diabetes. Increased ASI and decreased Ao distensibility are closely associated with diastolic filling indices measured by CE and TDE.Öğe A CML CASE WITH TWO ISCHEMIC CEREBROVASCULAR ATTACKS DURING NILOTINIB THERAPY(Pergamon-Elsevier Science Ltd, 2016) Ilhan, G.; Sarifakiogullari, A.; Kaya, H.[Abstract Not Available]Öğe DECREASED HDL SUBFRACTIONS IN SICKLE CELL DISEASE PATIENTS IS ACCOMPANIED BY A REDUCTION OF BOTH LCAT AND THE ACTIVATOR PROTEIN APOA-1(Elsevier Ireland Ltd, 2015) Aslan, M.; Ozturk, O. H.; Can, Y.; Yonden, Z.; Motor, S.; Kaya, H.; Oktay, G.[Abstract Not Available]Öğe A DIFFUSE LARGE B CELL LYMPHOMA CASE PRESENTING WITH FEMUR MASS(Pergamon-Elsevier Science Ltd, 2015) Ilhan, G.; Sarifakiogullari, A.; Agir, Y.; Bulgurcu, M.; Biliz, H.; Kaya, H.[Abstract Not Available]Öğe Effect of obesity on P-wave dispersion and QT dispersion in women(Nature Publishing Group, 2006) Seyfeli, E.; Duru, M.; Kuvandik, G.; Kaya, H.; Yalcin, F.Objective: The aim of this study was to investigate the effect of obesity on dispersion of P-wave duration and QTc interval in obese women. Methods: Forty-two obese women (Body mass index (BMI) 4073 kg/m(2), mean age 4579 years) and compared age-matched (BMI 2271 kg/m(2), mean age 41 +/- 6 years) twenty-five non-obese women were included in our study. Maximum and minimum P-wave duration, P-wave dispersion (difference between the maximum and the minimum P-wave duration), maximum and minimum QTc interval, and QTc dispersion (the difference between the maximum and the minimum QTc interval) were measured from 12-lead ECG. ECG's were transferred to a personal computer via a scanner and then used for magnification of 400 times by Adobe Photoshop software. Results: There was significant difference in BMI (40 +/- 3 vs 22 +/- 1 kg/m(2), P < 0.001, respectively) between obese and non-obese women. Obese women had higher Max. P-wave duration (116711 vs 94714 ms, P < 0.001), P-wave dispersion (51715 vs 26711 ms, P < 0.001), Max. QTc interval (449738 vs 419730 ms, P < 0.001) and QTc dispersion ( 57723 vs 38715 ms, P < 0.001) compared to non-obese women. A significant correlation was found between BMI and Max. P-wave duration (r = 0.584, P < 0.001), P-wave dispersion (r = 0.621, P < 0.001), Max. QTc interval (r = 0.410, P < 0.001), and QTc dispersion (r = 0.429, P < 0.001). In the linear regression analysis, compared to co-morbidity factors such as age, hypertension, diabetes mellitus and smoking, there was significant association between only BMI and electrocardiographic values (P-wave and QTc dispersion). Conclusion: We concluded that obesity caused significant increase in P-wave and QTc dispersion. Therefore, obese women may not only be under the risk of ventricular arrhythmias, but also they may under the risk of atrial arrhythmias.Öğe Family functioning and its clinical correlates in overweight and obese patients(Editrice Kurtis S R L, 2011) Bez, Y.; Ari, M.; Gokce, C.; Celik, M.; Kaya, H.AIM: Our aim is to evaluate the differences in family functioning and anxiety between normal, overweight, and obese subjects. METHOD: Overweight and obese patients were selected from the outpatient clinic of internal medicine department of a university hospital. Patients were classified into three groups as normal weight (N=82), overweight (N=33) and obese (N=50) patients. The normal weight group included healthy subjects. The individuals were examined by the same psychiatrist (MA). Beck Anxiety Inventory and Family Assessment Device were applied to all groups. RESULTS: When compared to normal weight patients, obese and overweight patients had significantly higher anxiety scores and higher scores in general functions, problem solving, communication, roles, affective responsiveness, and behavior control dimensions which reflect increased dysfunctions in their families. The total level of dysfunction that patients experience was predicted by alcohol dependence in the family during childhood period, any medical disorder in the current family, anxiety level and body mass index. CONCLUSION: When treating them clinicians should keep in mind that families of obese and overweight patients may have higher levels of dysfunctions. (Eating Weight Disord. 16: e257-e262, 2011). (C)2011, Editrice KurtisÖğe HERMANSKY-PUDLAK SYNDROME: REPORT OF A CASE AND REVIEW OF THE LITERATURE(Pergamon-Elsevier Science Ltd, 2014) Ilhan, G.; Acipayam, C.; Kaya, H.[Abstract Not Available]Öğe HYPERBILIRUBINEMIA AFTER ALCOHOL CONSUMPTION: TWO SICKLE CELL CASES(Pergamon-Elsevier Science Ltd, 2016) Ilhan, G.; Sarifakiogullari, A.; Kaya, H.[Abstract Not Available]Öğe Is There any Significant Association Between Irritable Bowel Syndrome and Cholelithiasis ?(Aves, 2008) Kuvandik, G.; Helvaci, M. R.; Ozkan, O. V.; Sogut, S.; Kaya, H.; Bozkurt, S.Background: We tried to understand whether or not there is a significant etiopathogenetic relationship between irritable bowel syndrome (IBS) and cholelithiasis. Methods: Consecutive patients with upper abdominal discomfort were included into the study. Routine hematologic and biochemical tests, an abdominal ultrasonography, and a questionnaire for IBS was performed in all cases, and IBS is diagnosed according to Rome II criteria in the absence of red flag symptoms. Cholelithiasis cases were put into one group and age and sex-matched and randomly selected cases without cholelithiasis were put into the other group. Prevalences of smoking, normal weight, overweight, obesity, and IBS were detected in each group and compared in between. Results: One hundred and twenty-one patients with cholelithiasis were diagnosed. Ninety-seven (80.1%) of them were female, and their mean age was 53.4 +/- 9.9 (27-70) years. Interestingly, 92.5% (112 cases) of the cholelithiasis cases had excess weight and obesity was significantly higher in the cholelithiasis group (54.5% vs. 43.8%, p<0.05). Prevalence of IBS was nearly equal in both groups (43.8% in cholelithiasis vs. 42.1% in control cases, p>0.05). Conclusions: IBS probably is a cascade of many physiological events, being initiated with infection, inflammation, psychological disturbances-like stresses and eventually terminated with dysfunctions of genitourinary tract and probably some other systems of body via a low-grade inflammatory process. Although IBS probably has a much more complex mechanism than the current view and a higher prevalence in society, there is not a significant association between IBS and cholelithiasis.Öğe Oxidase activity of ceruloplasmin and some acute phase reactant and trace element concentrations in serum of patients with chronic lymphocytic leukemia(Scottish Medical Journal, 2007) Gundogdu, M.; Kaya, H.; Gulcin, I.; Erdem, F.; Cayir, K.; Keles, M.; Yilmaz, A.In the present study, we aimed to investigate the parameters in serum of patients with chronic lymphocytic leukaemia (CLL) and correlate with the cancer stage. The serum concentrations of ceruloplasmin, a-1-acid glycoprotein, albuminumin, transferrin, copper, zinc, manganese, and ceruloplasmin oxidase activity were measured, and compared with those from a healthy control group. The serum from 34 patients with CLL were extracted before chemotherapy. Serum transferrin, allbuminumin and Zinc concentrations were lower in patients with CLL while serum a-1-acid glycoprotein, ceruloplasmin, copper concentrations, and ceruloplasmin oxidase activity were higher in CLL patients when compared with the control group. Although serum manganese concentration was lower in CLL groups than in the control group, the difference was not statistically significant. Serum transferrin concentration was lower in the early stage group compared with the advanced stage. Serum ceruloplasmin level positively correlated with serum ceruloplasmin oxidase activity in patients from the early stage group. Serum ceruloplasmin level positively correlated with serum ceruloplasmin oxidase activity in patients with advanced stage. In conclusion, increased serum ceruloplasmin oxidase activity, ceruloplasmin, a-1-acid glycoprotein, copper levels and decreased transferrin and albuminumin, unchanged manganese levels are associated with CLL and appear to be a consequence of the disease itself.Öğe Peripheral nervous system involvement in patients with sickle cell disease(Wiley-Blackwell Publishing, Inc, 2009) Okuyucu, E. E.; Turhanoglu, A.; Duman, T.; Kaya, H.; Melek, I. M.; Yilmazer, S.Peripheral nervous system involvement is rare in sickle cell disease (SCD). The aim of this study is to determine the peripheral nerve involvement electrophysiologically in SCD patients without clinically evident neurological signs, symptoms and to determine the relationship between the frequency of sickle cell crisis and peripheral neuropathy. Fifty-one patients with SCD and fifty-one healthy controls were enrolled to the study. Conventional electrophysiological studies of peripheral nerves were performed to all subjects. The data about the frequency of sickle cell crisis were obtained. Peripheral nervous sytem involvement was detected in ten (19.6%) patients. Five (9.8%) patients had sensorimotor axonal neuropathy, two (3.9%) sensory axonal neuropathy, one (2%) patient had ulnar sensory neuropathy and two (3.9%) had median sensory neuropathy. Sural nerve sensorial action potential was unobtainable in eight (15.7%) patients and prolonged F latencies were observed in three (5.9%). The frequency of neuropathy was higher in SCD patients when compared with the controls. The frequency of sickle cell crisis was not significantly correlated with peripheral neuropathy. Subclinical peripheral nerve involvement may be seen in SCD patients. Electrophysiological examinations are recommended in routine examination to diagnose early neuropathy in SCD patients without neurologic symptoms.Öğe A physiologic event's cascade: Irritable bowel syndrome may even terminate with chronic gastritis(2008) Helvaci, Mehmet Rami; Kaya, H.; Algin, M.C.; Yalcin, A.When specifically asked, about one third of people report recurrent upper abdominal discomfort, and irritable bowel syndrome (IBS) and chronic gastritis (CG) maybe the most frequently diagnosed ones among all. Consecutive patients with upper abdominal discomfort applying to the Internal Medicine Polyclinic were included into the study. IBS was diagnosed according to Rome II criteria and CG was diagnosed histologically. All cases with IBS were compared with the age and sex-matched randomly selected cases without IBS. One hundred and fifty-six patients with IBS and 179 patients without IBS were studied. CG was detected in 72.4% (113 cases) of cases with IBS, and only 36.3% (65 cases) in patients without IBS (p<0.001). IBS probably is a cascade of many physiological events, being initiated by infection, inflammation, psychological disturbances-like many stresses and eventually leading to dysfunctions of gut and other systems of the body via a low-grade inflammatory process. CG may be one of the terminating points of the physiological events' cascade, IBS. This may explain the high prevalence of IBS in society. Keeping in mind this association will be helpful during prevention, treatment, and follow up of these common pathologies in Primary Health Centers and Internal Medicine and Gastroenterology Polyclinics for physicians.Öğe Practical cut off values to determine body mass index(2008) Helvaci, Mehmet Rami; Ozer, C.; Kaya, H.; Yalcin, A.We tried to understand whether there are significant cut off values simply determining body mass index (BMI). The study was performed in Internal Medicine Polyclinics on consecutive check up patients aged between 15 and 70 years to see possible consequences of excess weight on health and to avoid debility induced weight loss in elders. Insulin using diabetics and patients with devastating illnesses were excluded to avoid their possible effects on weight. Cases were subdivided into three groups according to their body weights as under 65, between 65 and 85, and above 85kg groups and prevalences of underweight, normal weight, overweight, and obesity were determined. Sensitivity, specificity, and positive and negative predictive values of body weights to determine BMI were calculated. The study included 954 cases (566 females). Sensitivity of 65kg as a cut off value to detect normal weight was 61.0%, specificity 94.3%, positive predictive value 82.9%, and negative predictive value was 97.6%. Similarly, sensitivity, specificity, and positive and negative predictive values of 65 and 85kg to detect overweight cases were 71.5%, 63.3%, 56.2%, and 77.1% respectively. So both values were statistically significant to detect normal weight, overweight and obese individuals (p=0.000 for both). Although BMI is probably a more valuable parameter to show weight status, the cut off values of 65 and 85kg, as an easier way, have significant places, too.Öğe Seroprevalence of hepatitis C in patients with type 2 diabetes mellitus and non-diabetic on haemodialysis(Wiley, 2006) Ocak, S.; Duran, N.; Kaya, H.; Emir, I.Type 2 diabetes mellitus (DM) has emerged as the commonest cause of end-stage renal disease. Haemodialysis (HD) treatment constitutes a high-risk environment for the transmission of hepatitis C virus (HCV). The aim of this study was to establish a potential relationship between type 2 DM and HCV infection in HD patients. Of the 267 HD patients, 67 (25.1%) had type 2 DM and 200 (74.9%) were with diverse aetiology for end-stage renal disease. The serum markers of HCV infection were tested by a second-generation enzyme-linked immunosorbent assay test for, antibodies and by qualitative reverse-transcription polymerase chain reaction technique for viral RNA. The overall prevalence of anti-HCV antibodies and HCV RNA was found to be 12.7% (34/267) and 10.1% (27/267), respectively. Patients with type 2 DM were found to have a higher HCV prevalence compared with non-diabetic patients [20.8% (14/67) vs. 10% (20/200)] (p < 0.05). The mean period on dialysis of anti-HCV-positive patients with type 2 DM was shorter than that observed for anti-HCV-positive non-diabetic patients (43.9 +/- 9.8 months vs. 59.7 +/- 28.4 months) (p < 0.05). This study has shown that although the period on dialysis of diabetic patients are shorter than non-diabetic patients, the prevalence of HCV in HD patients with type 2 DM is higher than that detected in non-diabetic HD patients.
