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Öğe Demodex Parazytes in Schizophrenia(Derman Medical Publ, 2016) Kokacya, Mehmet Hanifi; Hamamci, Berna; Copoglu, Umit Sertan; Kaya, Ozlem AycanAim: Demodex parazytes are commonly present all over the world, especially in facial region of humans. Demodex spp. are assumed to be more common in schizophrenia due to partial suppression of immune system and lack of good self-care. The present study aimed to investigate the prevalence of Demodex ectoparasites in schizophrenia patients. Material and Method: In the study, 31 patients with a diagnosis of schizophrenia and 30 subjects without any psychiatric disorder or skin disease were subjected to standard superficial skin biopsy technique to determine Demodex spp. Results: Demodex spp. were found positive in nine schizophrenia patients and it was found positive in two healthy controls. Considering the prevalence of Demodex spp., a significant relationship is found between schizophrenia patients and normal controls (p< 0.05). Discussion: As a result, Demodex spp. are more common in schizophrenia due conditions of reduced self-care and immunosuppression, Demodex parasites should be considered in schizophrenia patients with skin lesions, especially on the face, and should to be treated if needed.Öğe Detection of primary clarithromycin resistance of Helicobacter pylori and association between cagA+ status and clinical outcome(Springer, 2013) Yula, Erkan; Nagiyev, Togrul; Kaya, Ozlem Aycan; Inci, Melek; Celik, M. Murat; Koksal, FatihHelicobacter pylori was examined in 110 patients (82 (74.5) with gastritis, 18 (16.4) with duodenitis, six (5.5) with duodenal ulcer and gastroesophageal reflux, and four (3.6 %) with normal) with gastrointestinal problems living in rural area, no history of macrolide use, and detected by culture (71.8) or direct detection from gastric biopsies by PCR (82.7 %). Also, cagA gene was identified using PCR and was found positive in 68/91 (74.7 %) strains. The prevalence of clarithromycin-resistant H. pylori was investigated by two methods including PCR-RFLP (7.7 (A2142G 1.1 and A2143G 6.6 %)) and twofold agar dilution (8.9 %) to detect phenotypic and genotypic status simultaneously. Among all the H. pylori positive patients, eight (8.8 %) isolates were found to be resistant to clarithromycin by at least one of the AD and/or PCR-RFLP methods. H. pylori positive rates were significantly correlated with patients' sex, age, and endoscopic findings (p = 0.040, < 0.001 and < 0.001, respectively). There were no differences in gender or endoscopic findings related to cagA (+) and cagA (-) patients. The gene of cagA was not significantly helpful in predicting the clinical outcome of H. pylori infection alone. In conclusion, we revealed that there was a low prevalence of primer clarithromycin resistance in patients living in rural area with no history of macrolide use. The prevalence of mutant strains among the macrolide-resistant H. pylori varies even geographically between close provinces.Öğe The Importance of Demodex Mites (Acari: Demodicidae) in Patients With Sickle Cell Anemia(Oxford Univ Press Inc, 2019) Kaya, Ozlem Aycan; Akkucuk, Serife; Ilhan, Gul; Guneri, Cansu Onlen; Mumcuoglu, KostaAlthough demodicosis caused by Demodex folliculorum and Demodex brevis is widely seen throughout the world, the pathogenic mechanisms are not fully known. To the best of our knowledge, the effect of Demodex mites in patients with sickle cell anemia (SCA) is not known. SCA is a genetic disease characterized by abnormal hemoglobin production and suppression of the immune system. The aim of this study was to determine the prevalence and Demodex density in SCA patients and to compare with healthy subjects. The study included 70 patients diagnosed with SCA and control group of 50 healthy individuals. Samples were taken from cheeks, forehead, nose, and chin and were examined microscopically. Infestation of >= 5 mites/cm(2) was accepted as positive in the diagnosis. Demodex mite positivity was determined in 20 (28.6%) patients and none in subjects of the control group. In the SCA group, the mean number of mites was 26.10/cm(2). A statistically significant correlation was found between Demodex mite positivity and the number of SCA symptom attacks experienced by the patients within the last 1 yr (P <= 0.001). No significant relationship was determined between Demodex mite positivity and age or gender (P = 0.56 and P = 0.11, respectively). Demodex mites are seen more often in SCA patients who suffer from a compromised immune system, and the presence of Demodex mites could be a risk factor in the appearance of SCA symptom attacks.Öğe The Incidence of Demodex folliculorum in the Combination of Allergic Rhinitis and Diabetes Mellitus(Iranian Scientific Society Medical Entomology, 2019) Arli, Cengiz; Ozsan, Muge; Gurkan, Eren; Kaya, Ozlem Aycan; Kokacya, SumeyyaBackground: Demodex mites are permanent ectoparasites of human pilosebaceous unit. They mainly infect skin of the face and scalp. Many studies have shown hi er density of the ectoparasites in diseased inflammatory skin than in normal skin. The aim of this study was to determine the frequency of Demodexfolliculorum (DE) in treatment-resistant patients with the combination of allergic rhinitis (AR) and diabetes mellitus (DM). Method: This study was conducted in 2014-2017. It included 92 patients aged 18-70 years who presented at the Ear, Nose and Throat (ENT) and Endocrinology Polyclinics of Mustafa Kemal University Medical Faculty Hospital, Turkey. An age and gender matched control group was formed of 30 healthy individuals. To determine the presence of DF, a few eyelashes were taken from eyelids in both groups. Then samples were examined under a light microscope. Results: DF positivity was determined in 44 (47.8%) of the 92 patients and in 1 (3.3%) of the 30 control group subjects. In the patient group, DF positivity was evaluated as present in 14 (43.7%) of the DM patients, in 12 (40%) of the AR patients and in 18 (60%) of the AR+DM patients. Statistically significant DF incidence was found in all three patient groups compared to the control group (P=0.001). The incidence in AR + DM group was not different from other patient groups. Conclusion: DM, AR, advanced age and obesity had prepared the environment for Demodex infestations. This issue should be considered especially in treatment of patients with AR+DM.Öğe Increased Density of Demodex Folliculorum May be Related to Additional Risk Factors Reply(Acad Medical Sciences I R Iran, 2016) Dokuyucu, Recep; Kaya, Ozlem Aycan; Yula, Erkan; Ustun, Ihsan; Bayram, Fahri; Gokce, Cumali[Abstract Not Available]Öğe Increased Density of Demodex folliculorum Mites in Pregnancies with Gestational Diabetes(Karger, 2014) Kurt, Raziye Keskin; Kaya, Ozlem Aycan; Karateke, Atilla; Silfeler, Dilek Benk; Karapinar, Oya Soylu; Akkoca, Ayse Neslin; Hakverdi, Ali UlviObjective: To investigate the presence of Demodex in patients with gestational diabetes and the impact of glucose regulation on Demodex density in gestational diabetes. Subjects and Methods: The study population consisted of 33 patients with gestational diabetes and 30 pregnant women without gestational diabetes (control group). The age, parity, gestational age, and BMI of the study group were recorded and the patients were divided into 2 groups, i. e. those with regulated and unregulated glucose levels, according to their postprandial 1st-and 2nd-hour glucose values. A standardized skin surface biopsy method was used to determine if patients had Demodex folliculorum infestation (> 5 mites/cm 2 of skin). Results: Patients with gestational diabetes had a statistically significantly higher Demodex density compared to the control group (24.2 vs. 3.3%; p < 0.001). Furthermore, a significantly higher proportion of gestational diabetes patients with unregulated glucose levels had a higher Demodex density compared to those in the regulated subgroup (6/19 vs. 2/14; p = 0.001). Conclusion: Our study revealed that the Demodex density was increased in gestational diabetes patients. Further, poor glucose regulation could be the mechanism responsible for the increased Demodex density in gestational diabetes patients with unregulated glucose levels compared to those with regulated glucose levels. (C) 2014 S. Karger AG, BaselÖğe [Investigating Demodex folliculorum in patients with urological cancer].(2012) Inci, Mehmet; Kaya, Ozlem Aycan; Inci, Melek; Yula, Erkan; Gökçe, Hasan; Rifaio?lu, M Murat; Demirtaş, OnurIn this study, it was aimed to determine frequency of Demodex folliculorum infestation in patients with urological cancers. This study evaluated 49 patients with urological cancers; 31 sex-matched healthy individuals as a control group were included in the study between March 2011 and April 2012 at the Hospital of Mustafa Kemal University, School of Medicine, Urology Clinic. The demographic characteristics of the patients were recorded. Samples from the perineal region of the subjects were taken by standard method of superficial skin biopsy and evaluated by microscopy. Presence of five or more Demodex sp. in a cm < sup > 2 < /sup > was considered as positive. Mean age was found to be 60.2±18.6 years. D. folliculorum was found to be positive in 11 (22.4%) of the patients with cancer and in 1 (3.2%) of the subjects in the control group. It was found that D. folliculorum frequency was significantly higher in the cancer group compared to the control group. No significant difference was found among the cancer groups in terms of D. folliculorum detection. In the cancer group, mean age was significantly higher in D. folliculorum positive patients than negative ones. It should be kept in mind that D. folliculorum incidence may increase in immunosuppressive states, such as cancer.Öğe Investigation of the presence of Trichomonas vaginalis in infertile Turkish women(Walter De Gruyter Gmbh, 2015) Kaya, Ozlem Aycan; Silfeler, Dilek Benk; Kurt, Raziye Keskin; Gozukara, Ilay; Yengil, Erhan; Bayramoglu, NeslihanBackground: Trichomoniasis is a sexually transmitted vaginal infection caused by a protozoan called Trichomonas vaginalis. Its prevalence ranges between 3-40% among randomly tested women. Objectives: To investigate the presence of T vaginalis in infertile women presenting to a Turkish gynecology outpatient clinic using parasitological methods. Methods: The study population comprised 51 patient participants who attended the gynecology clinic of Mustafa Kemal University Hospital between March and August 2013. The women were divided into those presenting with infertility (n = 22) and a patient control group (n = 29). Women in the control group had complaints other than infertility. Microscopic examination, Giemsa staining, and cysteine peptone liver maltose culture were performed on samples taken from posterior fornix tested for T vaginalis. Results: T vaginalis was observed in 18% (n = 4) of infertile patients and in none of the control group (P = 0.03). Conclusions: Asymptomatic infertile women should be examined for T vaginalis infection, which may play a role as a cause or contributing factor in infertility.Öğe Prevalence of Demodex spp among alcohol-dependent patients(Cukurova Univ, Fac Medicine, 2016) Kokacya, Mehmet Hanifi; Kaya, Ozlem Aycan; Copoglu, Umit Sertan; Elmacioglu, SibelPurpose: Demodex folliculorum and Demodex brevis are common ectoparasites found in humans and live on the pilosebaceous glands and hair follicles especially on the facial region. Chronic alcohol consumption can weaken immune system and cause more severe infections. Demodex spp is assumed to be more common in alcohol-dependent patients due to partial suppression of immune system and lack of good self-care. The present study aims to investigate the prevalence of Demodex spp. ectoparasite in alcohol-dependent patients. Material and Methods: In the study, 24 patients with a diagnosis of alcohol dependence and 24 healthy control subjects were subjected to standard superficial skin biopsy technique to determine Demodex spp. Results: In 37.5% of alcohol-dependent patients and 4.1% of control subjects Demodex spp. were found positive. Considering the prevalence of Demodex spp, a significant difference was found between alcoholdependent patients and control subjects. Conclusion: Demodex spp. are more common in alcoholdependent patients due conditions of reduced self-care and immunosuppression. Demodex parasites should be considered in alcohol-dependent patients with skin lesions, especially on the face, and should to be treated if needed.Öğe Re: Increased density of demodex folliculorum may be related to additional risk factors(Academy of Medical Sciences of I.R. Iran, 2016) Dokuyucu, Recep; Kaya, Ozlem Aycan; Yula, Erkan; Ustun, Ihsan; Bayram, Fahri; Gokce, Cumali[No abstract available]Öğe Relationship between demodex folliculorum and allergic rhinitis in adults(Acta Medica Mediterranea, 2014) Yengil, Erhan; Cevik, Cengiz; Kaya, Ozlem Aycan; Taner, Melis; Neslin Akkoca, Ayse; Ozer, CahitBackground and aim: Allergic rhinitis (AR) is a chronic disease, which exhibits rapid increase in recent years and affects approximately 30-40% of the population worldwide. Demodex folliculorum (DF) is an ectoparasite, which is prevalent in human skin. The aim of the present study was to investigate the frequency of DF at eyelashes and cheek in patients with allergic rhinitis and controls. Materials and methods: The study included 63 patients with allergic rhinitis and 65 healthy individuals. For DF evaluations, 4 eyelashes were taken from all individuals. Five samples of standardized skin surface biopsies (SSSB) were taken from each subject from the forehead, cheeks, jaw and nose. Results: For eyelashes, the frequencies of DF were found as 50.8% in AR group, whereas 38.1% in control group. For face, it was found as 38.1% in AR group, whereas 12.3% in control group. The frequencies of DF at face and eyelashes were found to be significantly higher in patients with AR than controls (p=0.001 and p=0.0001, respectively). The DF was detected at eyelashes in 63.9% of the patients with ocular symptoms vs. 33.3% of those without (OR: 3.5 (95% CI: 1.2-10.1); p=0.016), whereas it was detected at face in 52.8% of the patients with ocular symptoms vs. 18.5% of those without (OR: 4.9 (95%CI: 1.5-15.8); p=0.008). Conclusion: The frequencies of DF at eyelashes and face were significantly higher in patients with AR than healthy individuals. The higher frequency of DF in patients with AR suggests that AR facilitate the colonization of this mite.Öğe RELATIONSHIP BETWEEN DEMODEX FOLLICULORUM AND ALLERGIC RHINITIS IN ADULTS(Carbone Editore, 2014) Yengil, Erhan; Cevik, Cengiz; Kaya, Ozlem Aycan; Taner, Melis; Akkoca, Ayse Neslin; Ozer, CahitBackground and aim: Allergic rhinitis (AR) is a chronic disease, which exhibits rapid increase in recent years and affects approximately 30-40% of the population worldwide. Demodex folliculorum (DF) is an ectoparasite, which is prevalent in human skin. The aim of the present study was to investigate the frequency of DF at eyelashes and cheek in patients with allergic rhinitis and controls. Materials and methods: The study included 63 patients with allergic rhinitis and 65 healthy individuals. For DF evaluations, 4 eyelashes were taken from all individuals. Five samples of standardized skin surface biopsies (SSSB) were taken from each subject from the forehead, cheeks, jaw and nose. Results: For eyelashes, the frequencies of DF were found as 50.8% in AR group, whereas 38.1% in control group. For face, it was found as 38.1% in AR group, whereas 12.3% in control group. The frequencies of DF at face and eyelashes were found to be significantly higher in patients with AR than controls (p=0.001 and p=0.0001, respectively). The DF was detected at eyelashes in 63.9% of the patients with ocular symptoms vs. 33.3% of those without (OR: 3.5 (95% CI: 1.2-10.1); p=0.016), whereas it was detected at face in 52.8% of the patients with ocular symptoms vs. 18.5% of those without (OR: 4.9 (95%CI: 1.5-15.8); p=0.008). Conclusion: The frequencies of DF at eyelashes and face were significantly higher in patients with AR than healthy individuals. The higher frequency of DF in patients with AR suggests that AR facilitate the colonization of this mite.Öğe Sociodemographic characteristics of patients with Demodex brevis and Demodex folliculorum infestation and its association with rosacea and Behcet's disease.(Allied Acad, 2015) Durmaz, Suleyman; Yula, Erkan; Kaya, Ozlem Aycan; Gokmen, Aysegul Aksoy; Kilinc, Cetin; Atambay, Metin; Ekiz, OzlemDemodex mites are ectoparasites often found in the skin thought to be associated with the development of some skin diseases. Demodex positivity may be affected by several factors. In order to determine the relationship between Demodex infestation and rosacea disease (RD), Behcet's disease (BD) and various individual parameters such as gender, personal hygiene and skin type. A total of 238 individuals (61 with RD, 46 with BD, and 131 healthy subjects) were investigated for the presence of Demodex folliculorum and D. brevis using the standardized skin surface biopsy technique and a questionnaire. The incidence of Demodex mites in RD patients was significantly higher when compared to the control group (p=0.010 and p=0.001, respectively). However, there was no difference between those with BD and the control group. There was a significant difference between ages of groups, skin types, use of moisturizer, and itching, without taking into account the presence of Demodex among the disease groups (p<0.05). On the other hand, there was no significant difference between disease groups in terms of data of gender, skin care, epilation, and face washing. Our study reveals that the positivity rates of Demodex mites in rosacea patients were significantly higher. Mean ages of groups, skin types, use of moisturizer, and the presence of itching of the ear and face may be associated with higher density of Demodex mites.Öğe [An unusual Wohlfahrtia magnifica myiasis case localized in cutaneous and subcutaneous tissues in a patient with head-neck cancer].(2014) Cevik, Cengiz; Kaya, Ozlem Aycan; Akbay, Ercan; Ozkan, Mustafa; Kahraman, Ahmet; Uçak, MuratAuricular tumors constitute 6% of all head-neck tumors. Malignant tumors of the auricula are generally squamous or basal cell carcinomas. Myiasis rarely occurs in healthy individuals. In general, it is a parasite that is seen in patients with mental retardation or psychiatric disorders, elderly individuals, those with poor self-care and hygiene, and those with immune system disorders. In humans, it is mainly seen in tropical and subtropical regions; however, in rare instances, it may be seen in other regions of the world. In the literature, there are limited numbers of myiasis cases reported from Turkey. In this study, we aimed to present a myiasis case (Wohlfahrtia magnifica) involving cutaneous and subcutaneous tissues with an underlying head-neck cancer, which, to the best of our knowledge, has not been reported before in the literature.
