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Öğe Effect of zinc on the lipid peroxidation and the antioxidant defense systems of the alloxan-induced diabetic rabbits(Elsevier Science Inc, 2007) Duzguner, Vesile; Kaya, SuleThe effects of oral zinc supplementation on lipid peroxidation and the antioxidant defense system of alloxan (80-90 mg/kg)-induced diabetic rabbits were examined. Forty-five New Zealand male rabbits, 1 year old, weighing approximately 2.5 kg, were allocated randomly and equally as control, diabetic, and zinc-supplemented diabetic groups. After diabetes was induced, zinc-supplemented diabetic rabbits had 150 mg/L of zinc as zinc sulfate (ZnSO4) in their drinking tap water for 3 months. The feed and water consumption was higher in diabetic groups than (P < 0.01) healthy rabbits. The body weight was lower in diabetic rabbits compared to control. The blood glucose levels were higher in diabetic groups than controls. The elevated plasma malondialdehyde (MDA) levels were determined in the diabetic group (P < 0.01). The glutathione peroxidase (GSHPx), catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), and ceruloplasmin levels in the diabetic group were decreased by the effect of diabetes but there was no difference between zinc-supplemented diabetic and control rabbits. Serum zinc concentrations were lower in diabetic rabbits but iron (Fe) and copper (Cu) levels in sera were not different among the groups. As a result, it was concluded that daily zinc supplementation could reduce the harmful effects of oxidative stress in diabetics. (c) 2007 Elsevier Inc. All rights reserved.Öğe Influence of different dietary vitamin E supplementation on some plasma components and egg production of laying Japanese quails during heat stress(2007) Kaya, SuleThe experiment was conducted to evaluate the effects of vitamin E (dl-?-tocopherol acetate) supplementation at various concentrations (0-control-, 250, 500, 750 mg/kg of diet) on the feed intake, egg production, plasma enzymes, electrolytes and metabolites of laying quails (Coturnix coturnix japonica) exposed to chronic heat stress at a mean temperature of 31°C from 13 to 17 weeks of age. The quails were randomly assigned to 4 treatment groups, 3 replicates of 15 birds each. Body weight, feed intake and egg production were not affected by vitamin E supplementation. Plasma total cholesterol, total protein, alkaline phosphatase (ALP), blood urea nitrogen (BUN), inorganic P and Mg concentrations did not differ among the groups. Plasma creatinine was higher in the 750 mg/kg vitamin E supplemented group than in other vitamin E supplemented groups. Plasma glucose concentrations decreased as dietary vitamin E increased up to 500 mg/kg of the diet. A higher glucose concentration and activity of glutamic-oxaloacetic transaminase (GOT) were stated in the control group. Triglyceride concentration was the highest whereas albumin and Ca concentrations were higher in the control group than for the 250 and 750 mg/kg vitamin E supplemented groups. Plasma glutamic pyruvic transaminase (GPT) activity was the lowest in control group. These results indicate that the supplementation of 500 mg vitamin E/kg to the diet may offer a potential protective management practice for preventing heat stress-related damages in laying quails.Öğe Precipitation and exacerbation of psoriasiform eruption due to leuprolide acetate(Wiley-Blackwell, 2013) Erfan, Gamze; Rifaioglu, Emine N.; Kulac, Mustafa; Kalayci, Serkan; Kaya, Sule; Oznur, Meltem[Abstract Not Available]
