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Öğe Alkali metals (Na, K) doped ZnO/CuO composite films for real-time tracking of sweat loss(Elsevier Sci Ltd, 2023) Sahin, B.; Ozyilmaz, G.; Kaya, T.Real-time sweat rate monitoring provides clinically proper directives for preventive medicine and dis-ease diagnosis. This research represents an attempt to develop a semiconductor-based nanostructured sensor for monitoring sweat rate using a ZnO/CuO composite thin film. A series of alkali metals (sodium, Na; potassium, K) doped ZnO/CuO composite samples were fabricated on soda lime glass substrates by the Successive Ionic Layer Adsorption and Reaction method. The sweat solution sensing response characterization exhibited promising sensing behavior under room conditions. The Na-and K-doped samples showed a pronounced response at low and high concentrations of the sweat solution. While the undoped composite film responds to the high concentration sweat solution (117.90 mM) with a sensi-tivity of 4.10, this value increases up to 9.15 for the 2.0% Na-doped samples. In addition, the response time shortens from 6 s to 4 s for 2.0% Na substitutions. Pristine, 2.0% Na and 2.0% K-substituted ZnO/CuO composites exhibit great linearity with linear regression ranges, R2, of 0.958, 0.971, and 0.984, respec-tively. We concluded that doping of ZnO/CuO composites with alkali metals Na and K is a good candidate for real-time tracking of sweat loss as biological evidence.(c) 2023 Elsevier Ltd. All rights reserved.Öğe Effect of Hypericum thymbrifolium BOISS. ET NOE, Hypericum scabrum L. and Eryngium creticum LAM. plant extracts on Leishmania major, Leishmania tropica and Leishmania infantum/donovani strains and their cytotoxic potential(Malaysian Soc Parasitology Tropical Medicine, 2024) Ozpinar, H.; Culha, G.; Ozpinar, N.; Kaya, T.; Kara, B.; Yucel, H.Leishmaniasis causes significant morbidity and mortality worldwide. In our country, there has been a significant increase in the number of cases of leishmaniasis in the last decade. In our study, the effects of Hypericum thymbrifolium, Hypericum scabrum and Eryngium creticum plant extracts were tested on Leishmania major, Leishmania tropica and Leishmania infantum/donovani, which were clinically resistant by not responding to Glucantime (R) therapy. Cytotoxicity of these extracts were evaluated by XTT method in the human fibroblast cell line. Possible active ingredients were detected by GC-MS analysis from plant extracts. Glucantime (R) resistance was detected at concentrations of 50 p.g/mL and lower in 4 of the 7 strains tested. No living leishmania parasites were found in leishmania strains treated with plant extracts at concentrations of 100 p.g/mL or higher. The concentrations of plant extracts included in the study on the WI-38 human fibroblast cell line were not cytotoxic. According to the GC-MS analysis, several active substances with biological activities and anti-parasitic effects, such as Thiophene, Germacrene-D, trans-Geranylgeraniol, Pyridine, and Maleimides, were identified. Based on the findings of the study, it is believed that these identified active substances when supported by in-vivo studies, will pave the way for future research and have the potential to be developed as anti-leishmania drugs.Öğe Enhanced hydration detection properties of nanostructured CuO films by annealing(Elsevier Science Bv, 2016) Sahin, B.; Kaya, T.This work reports the effects of annealing on the material properties and sweat sensing behavior of nanostructured CuO-based films. CuO films were grown on glass substrates via SILAR (Successive Ionic Layer Adsorption and Reaction) method. Films were annealed at 200 degrees C and 400 degrees C in ambient air for 45 min. Scanning electron microscopy analysis confirmed the plate-like morphology of CuO nanostructures with average plate thickness increasing from 30 nm to 70 nm with increasing annealing temperature. X-ray diffraction studies of the films revealed that the average crystallite sizes were around 17-22 nm. The bandgap values were calculated from the UV-visible absorbance spectrum and it was determined that the annealing process lowered the bandgap valued from 1.46 eV to 1.38 eV suggesting that the resistivity would also decrease. The prospect of sweat electrolyte sensing properties of CuO films was studied by drop cast application of different concentrations of artificial sweat solutions. We found that annealing process increases the sensitivity of sweat electrolyte level detection for particularly low concentration artificial sweat solutions. (C) 2016 Elsevier B.V. All rights reserved.Öğe Hydration detection through use of artificial sweat in doped- and partially-doped nanostructured CuO films(Elsevier Sci Ltd, 2015) Sahin, B.; Alomari, M.; Kaya, T.A new method of sweat sensing based on nanostructured Copper Oxide (CuO) films is presented. Films were developed by the Successive Ionic Layer Adsorption and Reaction (SILAR) method. The morphological, structural and electrical properties of the CuO films were investigated by scanning electron microscopy, X-ray diffraction analysis, and room temperature current voltage measurements, respectively. We doped CuO films with artificial sweat during the film growth process. We also drop cast the surface of the intrinsic CuO films with artificial sweat to investigate the effect of partial doping. Our results showed that partial doping indeed gave results consistent with those of actual doping. The resistivity of the partially doped films was decreased with increasing artificial sweat concentrations. (C) 2015 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
