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    Esthetic Outcomes after Immediate and Late Implant Loading for a Single Missing Tooth in the Anterior Maxilla
    (Wolters Kluwer Medknow Publications, 2018) Yildiz, P.; Zortuk, M.; Kilic, E.; Dincel, M.; Albayrak, H.
    Objective: This study compared the esthetic outcomes of 1-year follow-up of immediate and late implant loading after implant restoration of a single tooth in the anterior maxilla. Materials and Methods: A total of 33 patients with missing teeth in the anterior maxilla (Central = 8/lateral = 22/canine = 3) were enrolled in this study (18 immediate loading and 15 late loading). At after cementation, 1, 3, 6, and 12 months photographs were taken of anterior maxilla. The photographs were assessed using pink esthetic score (PES) which consists of seven variables. All PES data were analyzed with independent sample t-tests and repeated measures ANOVAs. Results: PES values increased significantly in both groups at the 1-year follow-up (P > 0.05). There was no statistically significant difference between the immediate and late loading groups at any time point (P > 0.05). Conclusions: Within the limitation of this study, immediate loading did not have a negative effect on esthetics.
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    A Machine Learning Approach for the Association of ki-67 Scoring with Prognostic Factors
    (Hindawi Ltd, 2018) Dirican, E.; Kilic, E.
    ki-67 score is a solid tumor proliferation marker being associated with the prognosis of breast carcinoma and its response to neoadjuvant chemotherapy. In the present study, we aimed to investigate the way of clustering of prognostic factors by ki-67 score using a machine learning approach and multiple correspondence analysis. In this study, 223 patients with breast carcinoma were analyzed using the random forest method for classification of prognostic factors according to ki-67 groups (<14% and >14%). Also the relationship between subgroups of prognostic factors and ki-67 scores was examined by multiple correspondence analysis. There was a clustering of molecular classification LA, 0-3 metastatic lymph node, age <50, absence of LVI, T1 tumor size with ki-67 <14% and grade III, 10 or more metastatic lymph nodes, and presence of LVI and molecular classification LB, age >50, and T3-T4 tumor size categories with ki-67 >14%. The fact that the low scores of ki-67 correlate with early stage diseases and high scores with advanced disease suggests that 14% threshold value is crucial for ki-67 score.
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    Surgical outcomes of a civil war in a neighbouring country
    (Bmj Publishing Group, 2016) Akkucuk, Seckin; Aydogan, A.; Yetim, I.; Ugur, M.; Oruc, C.; Kilic, E.; Paltaci, I.
    Objectives The civil war in Syria began on 15 March 2011, and many of the injured were treated in the neighbouring country of Turkey. This study reports the surgical outcomes of this war, in a tertiary centre in Turkey. Methods 159 patients with civilian war injuries in Syria who were admitted to the General Surgery Department in the Research and Training Hospital of the Medical School of Mustafa Kemal University, Hatay, Turkey, between 2011 and 2012 were analysed regarding the age, sex, injury type, history of previous surgery for the injury, types of abdominal injuries (solid or luminal organ), the status of isolated abdominal injuries or multiple injuries, mortality, length of hospital stay and injury severity scoring. Results The median age of the patients was 30.05 (18-66years) years. Most of the injuries were gunshot wounds (99 of 116 patients, 85.3%). Primary and previously operated patients were transferred to our clinic in a median time of 6.284.44h and 58.11 +/- 44.08h, respectively. Most of the patients had intestinal injuries; although a limited number of patients with colorectal injuries were treated with primary repair, stoma was the major surgical option due to the gross peritoneal contamination secondary to prolonged transport time. Two women and 21 men died. The major cause of death was multiorgan failure secondary to sepsis (18 patients). Conclusions In the case of civil war in the bordering countries, it is recommended that precautions are taken, such as transformation of nearby civilian hospitals into military ones and employment of experienced trauma surgeons in these hospitals to provide effective medical care. Damage control procedures can avoid fatalities especially before the lethal triad of physiological demise occurs. Rapid transport of the wounded to the nearest medical centre is the key point in countries neighbouring a civil war.