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Öğe Adrenal myelolipoma: Case report(2008) Hakverdi, Sibel; Görür, Sadik; Temiz, Muhyittin; Akarsu, Bülent; Kiper, Ahmet NamikIntroduction: Adrenal myelolipoma are rare occurring benign tumors. They are generally less than 5cm and may not cause symptoms. We discuss a case with adrenal myelolipoma in the light of literature. A 60 year-old female patient had strait flank pain radiate to inguinal region. In the right adrenal gland, a mass about 8 cm was specified by ultrasonography and computerized tomography imaging. In the hystopathological evaluation of the completely resected mass, it was determined that the mass was composed of mature adipose tissue and hematopoetic elements, and the tumor was described as adrenal myelolipoma. In the cases with masses localized in the adrenal gland, adrenal myelolipoma should be considered. Therapy procedure should be planned according to size of the tumor and the presence of symptoms.Öğe ADRENAL MYELOLIPOMA: CASE REPORT(Aves, 2008) Hakverdi, Sibel; Gorur, Sadik; Temiz, Muhyittin; Akarsu, Bulent; Kiper, Ahmet NamikAdrenal myelolipomas are rare occurring benign tumors. They are generally less than 5cm and may not cause symptoms. We discuss a case with adrenal myelolipoma in the light of literature. A 60 year-old female patient had strait flank pain radiate to inguinal region. In the right adrenal gland, a mass about 8 cm was specified by ultrasonography and computerized tomography imaging. In the hystopathological evaluation of the completely resected mass, it was determined that the mass was composed of mature adipose tissue and hematopoetic elements, and the tumor was described as adrenal myelolipoma. In the cases with masses localized in the adrenal gland, adrenal myelolipoma should be considered. Therapy procedure should be planned according to size of the tumor and the presence of symptoms.Öğe The effect of caffeic acid phenethyl ester (CAPE) on histopathological changes in testicular ischemia-reperfusion injury(Academic Press Ltd Elsevier Science Ltd, 2006) Atik, Esin; Gorur, Sadik; Kiper, Ahmet NamikTesticular torsion causes an enhanced formation of reactive oxygen species which contributes to the pathophysiology of ischemia-reperfusion injury in the testis. We evaluated here the effect of caffeic acid phenethyl ester (CAPE), a new antioxidant and anti-inflammatory agent on histopathological changes in testicular ischemia-reperfusion injury. Adult male Wistar rats were divided into six groups of five each: control group I (n = 5), sham operation group 2 (n = 5), torsion/detorsion (T/D) group 3 (it = 5), T/D + saline group 4 (n = 5), T/D + CAPE group 5 (n = 5) and T/D + CAPE group 6 (n = 5). Group I served to determine baseline values of histopathological parameters, group 2 animals that underwent sham operation served as a control, while groups 3-6 animals were subjected to left unilateral torsion (2 h) and detorsion (24 h) periods. All the groups were sacrified 24 h later except group 6. CAPE was injected 2 days with the same dose to the group 6 and it was sacrified 48 h later. One testis removed and fixed in Bouin's solution. After routine tissue processing myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS) immunohistochemical methods were studied from paraffin embedded tissues. Treating rats with CAPE (applied at 10 mu mol/kg, 30 min prior to T/D) attenuated the testicular injury and as well as the tissue levels of MPO. At the same time testis tissue showed a decrease in iNOS activity. Our results suggest that CAPE treatment have a protective role on testicular T/D and this effect may be due to inhibiting the neutrophil mediated cellular injury. (c) 2006 Elsevier Ltd. All rights reserved.Öğe Effect of tamsulosin therapy on lower urinary tract symptoms in Parkinson's disease(2008) Görür, Sadik; Melek, Ismet Murat; Okuyucu, Esra; Helli, Ali; Duman, Taşkin; Kiper, Ahmet NamikIntroduction: The aim of this study is to evaluate the intensity of lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH) with and without Parkinson's disease (PD). We also investigated the efficacy of tamsulosin therapy in the management of the subjective and objective symptoms in these patients. Materials and Methods: This study included 80 (40 patients with and 40 without PD) clinically diagnosed BPH patients treated with tamsulosin. International Prostate Symptom score (IPSS), quality of life (QoL), maximum flow rate (Qmax) and post-void residual urine volume (PVR) were determined at baseline and after the 3 months of therapy. The PD group also evaluated with Unified Parkinson's Disease Rating Scale (UPDRS). All patients had received tamsulosin 0.4 mg/per day for 3 months period. The relationship between PD duration and UPDRS and mean changes of IPSS, QoL, Qmax and PVR after tamsulosin therapy were also investigated in PD group. Results: Three patients (7.5%) in PD group were discontinuied the therapy due to the severe hypotension attack. Initial data of IPSS, QoL, Qmax and PVR were different between two groups (p<0.001). After tamsulosin treatment, LUTS improved significantly in both groups (p<0.05). Improvement rates of the IPSS, QoL, Qmax and PVR were significantly higher in non-PD group (p<0.05). When relationship were investigated between PD duration and UPDRS and mean changes of IPSS, QoL, Qmax and PVR after tamsulosin therapy, all parameters were found in correlation except PVR. Conclusion: Tamsulosin therapy appears to useful in PD patient with BPH. But its efficacy is changed with PD duration and severity. After all, tamsulosin therapy can be given to these patients group with close follow-up.Öğe EFFECT OF TAMSULOSIN THERAPY ON LOWER URINARY TRACT SYMPTOMS IN PARKINSON'S DISEASE(Aves, 2008) Gorur, Sadik; Melek, Ismet Murat; Okuyucu, Esra; Helli, Ali; Duman, Taskin; Kiper, Ahmet NamikIntroduction: The aim of this study is to evaluate the intensity of lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH) with and without Parkinson's disease (PD). We also investigated the efficacy of tamsulosin therapy in the management of the subjective and objective symptoms in these patients. Materials and Methods: This study included 80 (40 patients with and 40 without PD) clinically diagnosed BPH patients treated with tamsulosin. International Prostate Symptom score (IPSS), quality of life (QoL), maximum flow rate (Qmax) and post-void residual urine volume (PVR) were determined at baseline and after the 3 months of therapy. The PD group also evaluated with Unified Parkinson's Disease Rating Scale (UPDRS). All patients had received tamsulosin 0.4 mg/per day for 3 months period. The relationship between PD duration and UPDRS and mean changes of IPSS, QoL, Qmax and PVR after tamsulosin therapy were also investigated in PD group. Results: Three patients (7.5%) in PD group were discontinuied the therapy due to the severe hypotension attack. Initial data of IPSS, QoL, Qmax and PVR were different between two groups (p<0.001). After tamsulosin treatment, LUTS improved significantly in both groups (p<0.05). Improvement rates of the IPSS, QoL, Qmax and PVR were significantly higher in non-PD group (p<0.05). When relationship were investigated between PD duration and UPDRS and mean changes of IPSS, QoL, Qmax and PVR after tamsulosin therapy, all parameters were found in correlation except PVR. Conclusion: Tamsulosin therapy appears to useful in PD patient with BPH. But its efficacy is changed with PD duration and severity. After all, tamsulosin therapy can be given to these patients group with close follow-up.Öğe Elastic properties of the aorta in patients with erectile dysfunction: assessment by conventional and color tissue Doppler echocardiography(Turkish Soc Cardiology, 2006) Seyfeli, Ergun; Gorur, Sadik; Akgul, Ferit; Gur, Mustafa; Seydaliyeva, Tunzale; Yalcin, Fatih; Kiper, Ahmet NamikObjectives: It has been suggested that erectile dysfunction (ED) may be the first clinical reflection of vascular disease. We investigated the stiffness and elastic properties of the aorta by conventional and color tissue Doppler echocardiography (TDE) in patients with ED of vascular origin. Study design: Thirty male patients with ED (mean age 52 +/- 8 years; range 41 to 73 years) were studied. Systolic and diastolic aortic diameters were measured by M-mode echocardiography to asses elastic properties of the aorta. Tissue Doppler velocities (S, E, and A cm/sec) of the upper and inferior aortic wall were measured by color TDE. Aortic strain and elasticity, and aortic stiffness index (ASI) were calculated. The results were compared with those of 30 healthy male controls (mean age 49 years). Results: Systolic and diastolic pressures and aortic systolic and diastolic diameters differed significantly between the two groups (p=0.001, p=0.034, p=0.045, p=0.004, respectively). Compared to controls, ASI was significantly higher (p=0.007), and aortic strain (p=0.002) and S wave velocity of the upper wall (p=0.001) were significantly lower in patients with ED. Significant correlations were found between S wave velocity of the upper wall with ASI (r=0.389, p=0.004), aortic strain (r=0.444, p=0.001) and elasticity (r=0.504, p<0.001), and between S wave velocity of the mitral lateral annulus and ASI (r=-0. 472, p<0.001) and aortic elasticity (r=0.533, p<0.001). Conclusion: Erectile dysfunction of vascular origin is associated with increased aortic stiffness and decreased aortic elasticity, this may foreshadow other vascular system diseases having a silent course.Öğe The prevalence and risk factors of enuresis in children aged between 6 and 18 years in Hatay(2008) Görür, Sadik; Inandi, Tacettin; Turhan, Ebru; Helli, Ali; Kiper, Ahmet NamikIntroduction: Aim of this study was to determine the prevalence and associated socio-demographic factors of enuresis among children aged between 6-18 years in Hatay. Materials and Methods: Five districts were selected in different geographic directions (east, west, north, south, and central) of Hatay. Five mother schools, twelve primary schools and twelve high schools were selected randomly from schools in these districts. The questionnaire was distributed to the students in order to fill by the parents. A total of 4000 questionaire were sent and re-collected one week later. Results: The percentage of the response rate was 74.6%. Age of the children ranges from 6 to 18 years (mean±SD; 11.26±3.03). Of the participants, 51.8% were girls and 48.2% were boys. Prevalence of enuresis were 7.4% in girls and 10.7% in boys (p=0.002). Mean age, body mass index and parents age were lower in the children with enuresis than the nonenuretics (p<0.001). Deficiency disorders, problems in friendship relation, failure in school, difficult aurosal, tonsillitis history, snoring and apnea were more frequent in the groups of enuresis (p<0.001). It was found that enuresis were more common in the children whose parents and siblings have enuresis history (p<0.001). The percentage of enuresis among the children with another urological problems was 27.4% (p<0.001). On the other hand, no relation was determined among the writing hand, birth place and birth type with enuresis. Child and mother age, bad friendship relations, low school success, enuresis history in siblings and parents and apnea period in sleeping were associated with enuresis in multipl logistic regression analysis. Conclusion: Enuresis seems associated with familial and behavioral factors. We suggest that evaluation of urinary and other systems in addition to physico-social behaviors of children and adolescence with enuresis may provide some benefit for management and therapy.Öğe THE PREVALENCE AND RISK FACTORS OF ENURESIS IN CHILDREN AGED BETWEEN 6 AND 18 YEARS IN HATAY(Aves, 2008) Gorur, Sadik; Inandi, Tacettin; Turhan, Ebru; Helli, Ali; Kiper, Ahmet NamikIntroduction: Aim of this study was to determine the prevalence and associated socio-demographic factors of enuresis among children aged between 6-18 years in Hatay. Materials and Methods: Five districts were selected in different geographic directions (east, west, north, south, and central) of Hatay. Five mother schools, twelve primary schools and twelve high schools were selected randomly from schools in these districts. The questionnaire was distributed to the students in order to fill by the parents. A total of 4000 questionaire were sent and re-collected one week later. Results: The percentage of the response rate was 74.6%. Age of the children ranges from 6 to 18 years (mean+/-SD; 11.26+/-3.03). Of the participants, 51.8% were girls and 48.2% were boys. Prevalence of enuresis were 7.4% in girls and 10.7% in boys (p= 0.002). Mean age, body mass index and parents age were lower in the children with enuresis than the nonenuretics (p<0.001). Deficiency disorders, problems in friendship relation, failure in school, difficult aurosal, tonsillitis history, snoring and apnea were more frequent in the groups of enuresis (p<0.001). It was found that enuresis were more common in the children whose parents and siblings have enuresis history (p<0.001). The percentage of enuresis among the children with another urological problems was 27.4% (p<0.001). On the other hand, no relation was determined among the writing hand, birth place and birth type with enuresis. Child and mother age, bad friendship relations, low school success, enuresis history in siblings and parents and apnea period in sleeping were associated with enuresis in multipl logistic regression analysis. Conclusion: Enuresis seems associated with familial and behavioral factors. We suggest that evaluation of urinary and other systems in addition to physico-social behaviors of children and adolescence with enuresis may provide some benefit for management and therapy.Öğe PROSTATE ADENOCARCINOMA WITH HEMORRHAGIC CYST FORMATION: A CASE REPORT AND REVIEW OF THE LITERATURE(Aves, 2006) Gorur, Sadik; Balcı, Ali; Karazincir, Sinem; Guven, Esref Oguz; Sumbas, Haldun; Kiper, Ahmet NamikIntroduction: Prostate adenocarcinoma accompanied with hemorrhagic cyst formation is a rare entity. It is usually diagnosed incidentally in patients who represent to urology clinics with compliant of lower urinary tract symptoms (LUTS). Here, we presented a 70-year-old man who has LUTS and serum PSA level of 102.35 ng/ml.Öğe Prostate adenocarcinoma with hemorrhagic cyst formation: A case report and review of the literature(2006) Görür, Sadik; Balcı, Ali; Karazincir, Sinem; Güven, Eşref O?uz; Sumbas, Haldun; Kiper, Ahmet NamikIntroduction: Prostate adenocarcinoma accompanied with hemorrhagic cyst formation is a rare entity. It is usually diagnosed incidentally in patients who represent to urology clinics with compliant of lower urinary tract symptoms (LUTS). Here, we presented a 70-year-old man who has LUTS and serum PSA level of 102.35 ng/ml.Öğe Renal myxoma: a case report and review of the literature(Aves, 2010) Hakverdi, Sibel; Gorur, Sadik; Yaldiz, Mehmet; Kiper, Ahmet NamikMyxomas are uncommon soft-tissue neoplasms, which are extremely rare in the kidney. In the present case, a right nephrectomy was performed because of suspected presence of a malignant renal tumor. In the macroscopic examination, the kidney contained a well-circumscribed, yellowish, and gelatinous tumor. The tumor was measured 6 cm in diameter. It was composed of fibroblast-like, slender spindle cells with myxoid stroma. With these histopathological findings, the case was diagnosed as renal myxoma. The case was discussed in the light of literature.
