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  • Küçük Resim
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    Effect of oral misoprostol, alone or in combination with aglepristone, on mid-term pregnancy termination in cats
    (Sage Publications Ltd, 2019) Ay, Serhan Serhat; Aslan, Selim; Onyay, Firdevs; Kaya, Duygu; Koldas, Ece; Arslan, Serhat; Findik, Murat
    Objectives This study aimed to determine the efficacy and safety of oral misoprostol (MIS) administration in the induction of mid-term pregnancy termination in cats. Methods Twenty-eight cats that were pregnant for 30-40 days were allocated to four groups. The aglepristone (AGL) group (n = 7) received 10 mg/kg SC aglepristone q24h for two consecutive days. In the AGL+MIS group (n = 7), AGL (as administered in the AGL group) and MIS (200 mu g/cat PO q12h until the start of abortion) were administered. The MIS200 (n = 7) and MIS400 groups (n = 7) received MIS (200 or 400 mu g/cat misoprostol, respectively) alone PO q12h until the start of abortion. Blood samples were collected at the start of treatment (d0), 4 days after the start of treatment (d4) and on the day of complete abortion/end of administration (dA/d7). Results The efficacy of the treatment was 71.4% in the AGL group, 100% in the AGL+MIS group, 0% in MIS200 group and 57.4% in MIS400 group (P = 0.004). No significance was found in relation to the interval from treatment to the start/end of abortion and the duration of abortion in all groups. The most observed side effect was vomiting in both groups administered MIS, particularly in the MIS400 group (56.7%). Progesterone (P4) concentrations were reduced during the abortion, but not to basal levels, in all groups. P4 concentrations were significantly lower at dA/d7 in the MIS400 group compared with the AGL and AGL+MIS groups (P = 0.002). Conclusions and relevance The results obtained from this study showed that low doses of MIS do not induce abortions in cats but increase the effect of AGL. Although higher doses could terminate pregnancies, this also causes intense unwanted side effects. Therefore, the use of MIS alone as an abortifacient in cats is not recommended. For mid-term pregnancy termination in cats, the combination of misoprostol and aglepristone provides a more effective abortifacient than using either of them alone.
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    Efficiency of vaginal electrical impedance to determine the stage of the reproductive cycle in bitches
    (Polish Soc Veterinary Sciences Editorial Office, 2018) Gurler, Hande; Koldas, Ece; Onyay, Firdevs Binli; Akcay, Aytac
    A study was carried out to compare the efficiency of vaginal electrical impedance with serum progesterone profile, cytological examination and clinical findings. Vaginal electrical impedance values varied at the different stages of the estrous cycle, with the highest value during the transition into estrous and the lowest in diestrus (P < 0.05). There was a negative statistical correlation between serum progesterone values and the impedance values (36%) (P < 0.001). Vaginal electrical impedance was a faster and cheaper method than progesterone assessment. It was more reliable than vaginal cytology and clinical evaluation. In conclusion, a combination of vaginal electrical impedance measurements and progesterone evaluation was a more useful method for determination of the optimal breeding time in bitches.
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    INVESTIGATION ON THE ETIOLOGY OF SUBCLINICAL MASTITIS IN JERSEY AND HYBRID JERSEY DAIRY COWS
    (Sciendo, 2015) Gurler, Hande; Findik, Arzu; Gultiken, Nilgun; Ay, Serhan Serhat; Ciftci, Alper; Koldas, Ece; Arslan, Serhat
    The aim of this study was to investigate the etiology of subclinical mastitis (SCM) in dairy Jersey cows with the use of bacteriological and molecular identification methods. In the study 121 Jersey and 78 hybrid Jersey cows with SCM were observed in the Samsun district of Turkey. A total of 411 California mastitis test (CMT) positive milk samples from these animals were examined bacteriologically. The prevalence of subclinical mastitis was 54.75% and 67.2% in Jerseys and hybrids, respectively. On bacteriological examination, a total of 92 strains were isolated from 411 milk samples. The most prevalent bacteria were Staphylococcus spp. (69.56%). Among them 24 isolates were Staphylococcus aureus (26.08%) the other isolates were Streptococcus dysgalactiae (23.91%), Enterococcus spp. (3.26%) and Streptococcus agalactiae (3.26%). All strains were identified with bacteriological culture methods, as well as by Polymerase Chain Reaction (PCR). Gram-negative bacteria were not isolated. In conclusion, the etiology of SCM in full blood and hybrid Jersey dairy cows in Samsun and the prevalence of bacteria were determined. The relatively high prevalence of SCM indicates the potential need for the consideration of some factors contributing to the formation of mastitis (e.g. management) as well as bacterial agents. The present study and further studies may be useful to develop mastitis vaccines by means of providing true vaccine strain sources.