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    Adenosine deaminase and biochemical liver function tests in the dermatophytic cattle
    (Natl Veterinary Research Inst, 2006) Atakisi, Emine; Karapehlivan, Mahmut; Atakisl, Onur; Kontas, Tunay; Marasli, Saban
    Adenosine deaminase (ADA) activity and liver function tests were examined in dermatophytic cattle. In addition, the possible effect/s of the disease oil the activities of liver enzymes were investigated. Tell dermatophytic and 10 healthy animals aged between 10 and 12 months were used. Blood samples were obtained from each animal. The samples were left for 30 min at room temperature, and then centrifuged at 3000 x g for 10 min. Serum ADA, lactate dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotransferase (AST). gammaglutamyl transferase (GGT) Were analysed colorimetrically. Serum ADA, LDH, and ALT activities were significantly higher in dermatophytic cattle, compared to those of healthy group (P < 0.01). ill addition. GGT and AST activities ill dermatophytic cattle were statistically compared higher to those of the healthy ones. Ill conclusion, the results of the present Study show that the increases in ADA and liver enzyme activities call be in indication of the loss of liver function. The increase in enzyme activity in the current study might have been caused by metabolic products of the Fungi.
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    Effect of Caffeic Acid Phenethyl Ester on Plasma Lipid Peroxidation, Antioxidant Status and Nitric Oxide Levels in Incisional Wound Model
    (Deri Zuhrevi Hastaliklar Dernegi, 2007) Serarslan, Gamze; Altug, Muhammed Enes; Kontas, Tunay
    Background and Design: Wound healing is a complex pathophysiologic process involving interplay of several cellular and biochemical processes. Several natural products have been shown to accelerate the healing process in studies. In this study we aimed to determine the efficacy of caffeic acid phenethyl ester (CAPE), which is an extract of honeybee propolis on wound healing in rats. Materials and Methods: Fourty male Wistar albino rats were divided into two groups as treatment (n=20) and control (n=20) group. A linear full thickness incision was performed on the back of each rat and sutured. After incision, during the study period CAPE was administered to the treatment group and saline was administered to the control group every day. Bloods of 5 animals from each group were collected on the experiment days of 1st, 3rd, 7th and 14th for biochemical analysis. Results: A significant increase in glutathione and nitric oxide levels and a significant decrease in malondialdehyde levels and superoxide dismutase activities in CAPE group were detected when compared to the control group. Conclusion: In the study it determined that CAPE showed an antioxidant effect on wound healing and suppressed lipid peroxidation. In conclusion, because of these properties, CAPE may be useful in wound healing.
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    Effect of the N-acetylcysteine and selenium on healing of experimental maxillary sinusitis caused by Staphylococcus aureus
    (Academic Journals, 2012) Akoglu, Ertap; Hakverdi, Sibel; Kontas, Tunay; Duran, Nizami; Altug, Muhammed Enes; Onel, Suleyman Ercument; Okuyucu, Semsettin
    The purpose of this controlled-randomised study was aimed to test the antioxidative effect of the N-acetylcysteine (NAC) and selenium on healing of Staphylococcus aureus sinusitis. After experimental sinusitis, 30 New Zealand rabbits were randomly divided into three groups; group A was treated with Ampicillin/sulbactam and physiological saline. Group B and C were treated with NAC and selenium in addition to Ampicillin/sulbactam, respectively. The measurements were repeated at the 3rd and 10th day. Serum malondialdehyde (MDA) levels and superoxide dismutases (SOD) activities at the 3rd day of experiment were higher than basal levels in all groups. These levels at the 10th day were lower than those of the 3rd day in groups B and C, significantly. The severity of the grade of inflammation and epithelial changes were significant between the infected and control side, but no significant change was found among the groups. S. aureus sinusitis causes to increase the level of reactive oxygen species (ROS) in the blood. These increased levels of ROS can be neutralized in some degree by antioxidative effects of NAC and selenium which are supplemented to standard antibiotic therapy. The effect of NAC and selenium on healing of maxillary sinus mucosa seems to be insignificant.
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    The protective effect of darbepoetin alfa on experimental testicular torsion and detorsion injury
    (Wiley, 2007) Akcora, Bulent; Altug, Muhammed Enes; Kontas, Tunay; Atik, Esin
    Aim: Testicular torsion is a serious urological emergency, usually involving newborns, children, and adolescents which can lead to subfertility and infertility. Prevention of testicular damage caused by torsion is still a clinical and experimental problem. So far many chemicals and drugs have been investigated for decreasing ischemia/reperfusion (I/R) injury in experimental animals. The possible protective effect of darbepoetin alfa, a novel erythropoietic protein, on testicular tissue after I/R injury was examined in this study. Methods: Thirty rats were divided into three groups: sham operation, torsion/detorsion, and torsion/detorsion plus darbepoetin alfa groups. After torsion (2 hours) and detorsion (4 hours), bilateral orchiectomy was performed. Malondialdehyde, nitric oxide and glutathione levels were determined in testicular tissue. Results: Administration of darbepoetin alfa caused a decrease of malondialdehyde and nitric oxide levels and an increase in glutathione levels compared with the torsion/detorsion group. In addition, histological injury scores were significantly decreased in the treatment group more than the torsion/detorsion group. Conclusion: The results suggest that darbepoetin alfa may be a potential protective agent for preventing testicular injury caused by testis torsion.
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    The protective effect of erythropoietin and dimethylsulfoxide on ischemia-reperfusion injury in rat ovary
    (Elsevier Science Bv, 2010) Ergun, Yasar; Koc, Ahmet; Dolapcioglu, Kenan; Akaydin, Yesim; Dogruer, Gokhan; Kontas, Tunay; Kozlu, Tolunay
    Objectives: The aim of this study was to investigate the effects of erythropoietin and dimethylsulfoxide in the recovery from ischemia-reperfusion injury in an experimental rat adnexal torsion model. Study design: Thirty-six Wistar-albino rats were divided into six groups. Except for the sham operation group, all groups were subjected to left unilateral adnexal torsion for 3 h. Erythropoietin and dimethylsulfoxide were intraperitoneally administered 30 min before the detorsion operation. Malondialdehyde and nitric oxide levels were detected from both the plasma and the tissue samples. The sections of the tissues were evaluated histologically. The results were analyzed by a one-way analysis of the variance (ANOVA) followed by the Duncan test for multiple comparisons using computer software, SPSS Version 15.0 for Windows. Results: This study demonstrated that dimethylsulfoxide and erythropoietin pretreatment attenuated ischemia-reperfusion-induced lipid peroxidation, prevented post-ischemic ovarian injury and helped to maintain the ovarian morphology. Malondialdehyde levels of plasma and ovary were higher in the torsion and detorsion groups than the sham group. This showed that ischemia-reperfusion had caused lipid peroxidation of the ovarian tissue, thus leading to oxidative damage. One of the major findings of this study is that malondialdehyde was significantly decreased in the plasma of rats who were pre-treated with dimethylsulfoxide and erythropoietin before detorsion. This suggests that dimethylsulfoxide and erythropoietin might prevent oxidative damage in ovarian ischemia-reperfusion injury. Histological examination confirmed that reperfusion caused more detrimental effects than only ischemia, which could be at least partially prevented by dimethylsulfoxide and erythropoietin administration prior to detorsion. Conclusion: Erythropoietin and dimethylsulfoxide may have beneficial effects in ischemia-reperfusion injury in ovarian torsion. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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    Tumour necrosis factor-?, adenosine deaminase and nitric oxide levels in cattle babesiosis before and after treatment
    (Natl Veterinary Research Inst, 2006) Kontas, Tunay; Salmanoglu, Berrin
    Changes in serum tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO), and adenosine deaminase (ADA) levels in cattle babesiosis before and after treatment with diminazene aceturate were determined. Before treatment, TNF-alpha, NO, and ADA levels were found to be 71.93 pg/ml, 50.03 mu mol/L, 70.18 IU/L, respectively. These levels were significantly higher than those in the control group. After the treatment, the levels Of the compounds significantly decreased. In Conclusion, besides TNF-alpha and NO, ADA can also be a predictive and sensitive parameter in the diagnosis and prognosis of babesiosis.