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    Effect of colchicine on polycystic ovary syndrome: an experimental study
    (Springer Heidelberg, 2016) Gozukara, Ilay Ozturk; Pinar, Neslihan; Ozcan, Oguzhan; Ozgur, Tumay; Dokuyucu, Recep; Kurt, Raziye Keskin; Kucur, Suna Kabil
    Purpose To investigate whether there is any therapeutic effect of colchicine on a rat model of polycystic ovary syndrome (PCOS). Methods Twenty-two Wistar-Albino rats were randomly assigned into four with 8 rats in each group: control group; PCOS only group; PCOS-metformin group and PCOS-colchicine group. PCOS was induced by gavage with letrozole once daily at the concentration of 1 mg/kg orally with 21 consecutive days. After PCOS model assessment, PCOS-metformin group was received metformin orally with 500 mg/kg and PCOS-colchicine group was received colchicine orally with 1 mg/kg for the 35 day. Histopathology of ovaries, circulating estrone (E-1), estradiol (E-2), total testosterone, androstenedione and c-reactive protein (CRP) levels were evaluated. Results: cystic and atretic follicle number was significantly decreased, but CRP and hormone parameters were not significantly changed with colchicine treatment. Conclusion Colchicine has provided histopathological improvement compared with metformin in PCOS rat model.
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    Histopathologic and metabolic effect of ursodeoxycholic acid treatment on PCOS rat model
    (Taylor & Francis Ltd, 2016) Gozukara, Ilay; Dokuyucu, Recep; Ozgur, Tumay; Ozcan, Oguzhan; Pinar, Neslihan; Kurt, Raziye Keskin; Kucur, Suna Kabil
    The aim of this study was to determine the effect of ursodeoxycholic acid (UDCA) treatment on a polycystic ovary syndrome (PCOS) rat model. Thirty-two female Wistar-Albino rats were randomly divided into four groups as follows - group 1: sham group (n: 8), group 2: letrozole-induced PCOS group (n: 8), group 3: letrozole-induced PCOS plus metformin-treated (500 mg/kg) group (n: 8) and group 4: letrozole-induced PCOS plus UDCA (150 mg/kg)-treated group (n: 8). Histopathologic examination of the ovaries, circulating estrone (E1), estradiol (E2), testosterone, androstenedione, glucose, insulin and lipid profiles were evaluated. Histopathologic examination results revealed that groups 3 and 4 had significantly lower cystic and atretic follicles compared to group 2. Besides, group 4 had significantly higher antral follicles than group 2 (8.5 +/- 2.9 versus 5.4 +/- 1.1; p: 0.001). Furthermore, total testosterone (4.9 +/- 2.8 versus 8.8 +/- 2.9; p=0.004) and insulin levels were significantly lower in group 4 compared to group 2 (1.7 +/- 0.08 versus 2.1 +/- 0.5; p = 0.02). However, lipid parameters, E1, E2, glucose and HOMA-IR were comparable between the groups. Our study results demonstrated that UDCA therapy improves ovarian morphology and decreases total testosterone and insulin levels.
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    Mean Platelet Volume, a Novel Biomarker in Adolescents with Severe Primary Dysmenorrhea
    (Elsevier Science Inc, 2016) Kucur, Suna Kabil; Seven, Ali; Yuksel, Kadriye Beril; Sencan, Halime; Gozukara, Ilay; Keskin, Nadi
    Study Objective: To evaluate whether mean platelet volume (MPV) would be a profitable marker in predicting disease severity in adolescents with severe primary dysmenorrhea (PD). Design, Setting, Participants, Interventions, and Main Outcome Measures: A total of 67 patients diagnosed with PD and 37 healthy adolescents with regular menstrual cycles were included in the study. Hemoglobin, MPV, and white blood cell, platelet, lymphocyte, and neutrophil counts were measured as part of the automated complete blood examination. Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio were obtained from the absolute neutrophil or platelet count, respectively, divided by the absolute lymphocyte count. The visual analog scale was used to assess the level of pain, as mild (<40 mm), moderate (40-60 mm) and severe ( >60 mm) PD. Results: The MPV level of the combined severity of PD and control groups were similar. However, the MPV was significantly lower in the severe PD group compared with the control group (P = .04). There were no significant differences in the other hematological parameters between the groups. The mean visual analog scale score of the PD and control subjects were 7.35 +/- 2.25 and 1.07 +/- 1.96, respectively (P < .01). There was a poor negative correlation, which was statistically insignificant, between MPV and white blood cell count. Conclusion: The present study showed that MPV is decreased in adolescents with severe PD. Further studies with larger numbers of subjects are necessary to clarify the roles of platelets in the pathogenesis of severe PD and evaluate the changes in MPV value in response to treatment.