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    The effect of lavender oil on serum testosterone levels and epididymal sperm characteristics of formaldehyde treated male rats
    (Verduci Publisher, 2011) Kose, E.; Sarsilmaz, M.; Meydan, S.; Sonmez, M.; Kus, I.; Kavakli, A.
    Background and Objectivies: In this study, the harmful effects of formaldehyde (FA) on serum testosterone levels and epididymal sperm characteristics were investigated. In addition, possible protective effect of lavender oil was evaluated. Materials and Methods: For this purpose, 21 adult male Wistar-Albino rats were used. The rats of group I was used as control group. The rats of group II were exposed FA (10 ppm/1 hour) for 35 days. The rats of group III inhaleted lavender oil (1 ml/1 hour) with FA. Results: While the testosterone levels, the epididymal sperm concentration and the progressive sperm motility were significantly decreased, the abnormal sperm rate was significantly increased in FA treated group when compared to control group. However, in group III, the epididymal sperm concentration and the progressive sperm motility were significantly increased, the abnormal sperm rate was significantly decreased in comparison with the FA treated group. Conclusion: It can be expressed that serious damages occured via formaldehyde exposure in reproductive system and that the lavender oil had protective effects against these damages.
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    Protective effect-of melatonin against formaldehyde-induced kidney damage in rats
    (Sage Publications Inc, 2007) Zararsiz, I.; Sarsilmaz, M.; Tas, U.; Kus, I.; Meydan, S.; Ozan, E.
    This study was undertaken to investigate the protective effects of melatonin against formaldehyde-induced renal damage in rats. For this purpose, 21 male Wistar rats were divided into three groups. The animals in Group I were used as a control, whereas the rats in group II were injected every other day with formaldehyde. The rats in group III received melatonin daily while exposed to formaldehyde. At the end of the 14-day experimental period, all rats were killed by decapitation, and the kidneys were removed. Some of the renal tissue specimens were used for determination of superoxide dismutase, glutatione peroxidase enzyme activities, and malondialdehyde levels. The remaining kidney tissue specimens were used for light microscopic evaluation. The renal tissue activities of superoxide dismutase and glutatione peroxidase were significantly decreased, and malondialdehyde levels were significantly increased in rats treated with formaldehyde compared with those of the control animals. In the light microscopic evaluation of this group, degenerative glomerules, vacuolization and dilatation of distal tubules, and vascular congestion were detected. However, an increase was observed in activities of superoxide dismutase and glutatione peroxidase enzymes, and a decrease of malondialdehyde levels in animals treated with formaldehyde plus melatonin was observed. Furthermore, the histopathological changes caused by formaldehyde were disappeared except for minimal tubular dilatation in this group. In conclusion, the biochemical and histological findings of our study suggest that melatonin administration prevents formaldehyde-induced oxidative renal damage in rats.