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    Clinical efficacy of diclofenac sodium and flunixin meglumine as adjuncts to antibacterial treatment of respiratory disease of calves
    (Wiley-Blackwell, 2010) Guzel, M.; Karakurum, M. C.; Durgut, R.; Mamak, N.
    Objective To compare the efficacy of the non-steroidal antiinflammatory drugs, diclofenac sodium and flunixin meglumine as adjuncts to the antibiotic treatment of bovine respiratory disease (BRD). Procedure We randomly allocated 80 Holstein calves with BRD to three groups. All the calves received a dose of 2.5 mg/kg tulathromycin by single subcutaneous injection and two of the groups received, in addition, either 2.5 mg/kg diclofenac sodium as a single intramuscular injection (diclofenac group, n = 30) or 2.2 mg/kg flunixin meglumine as an intravenous injection on the first three consecutive days after tulathromycin administration (flunixin group, n = 30). All calves were given a clinical score prior to initial treatment (day 0) and after treatment (days 1, 2, 3, 7 and 14) by observing appetite, demeanour, rectal temperature, the rate and type of respiration, presence or absence of coughing, and nasal discharge. Results During the first 48 h, improvement of adverse signs of respiratory disease, such as pyrexia and elevated respiratory rate, and of a high clinical index score was significant in the two adjunct groups compared with the calves receiving antibiotic alone. The reduction in pyrexia was greatest in the diclofenac group. There were no statically significant differences between treatment groups with regard to eventual perceived recovery from respiratory disease in 14 days. Conclusion In this trial, a single intramuscular dose of diclofenac sodium was equally effective as three intravenous injections of flunixin meglumine given on consecutive days as adjunctive therapy for BRD.
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    Frequency of blood types DEA 1.1, 3, 4, 5, and 7 in Kangal dog
    (Ecole Nationale Veterinaire Toulouse, 2009) Arikan, S.; Guzel, M.; Mamak, N.; Ograk, Y. Z.
    Despite clinical significance of the blood typing, relatively little is known about the prevalence of canine blood groups. This study aimed to determine the frequency of blood types DEA 1.1, 4, 5. and 7 in Kangal dogs, a Turkish shepherd dog. A total of 198 Kangal dogs were surveyed from local government organizations and private breeders living around Kangal town of Sivas province in Eastern Turkey. Blood typing was performed using tube agglutination assay. Of the 198 dogs, 61.1% had DEA 1.1 positive reactions. Approximately one fourth of dogs (232%) were positive for DEA 3. All dogs (100%) were positive for DEA 4. Prevalence of DEA 5 and 7 positive dots wits 55.5% and 71.7% respectively. The most common blood type, were DEA 1.1, 4 and 7. DEA 4 does not seem to be important for Kangal dogs in terms of transfusion medicine, since all dots have DEA 4 positivity. The prevalence and antigenic properties of DEA 1.1 and 7 are significantly high, which might create acute hemolytic transfusion reactions if unmatched transfusion is performed in Turkish Kangal dogs.