Yazar "Marin, Stefania" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim
    Öğe
    ANTI-INFLAMMATORY DRUG-LOADED BIOPOLYMERIC SPONGIOUS MATRICES WITH THERAPEUTIC PERSPECTIVES IN BURNS TREATMENT
    (Soc Stinte Farmaceutice Romania, 2018) Udeanu, Denisa Ioana; Kaya, Madalina Georgiana Albu; Ghica, Mihaela Violeta; Marin, Stefania; Marin, Maria Minodora; Kaya, Durmus Alpaslan; Popa, Lacramioara
    The most important goals of burns treatment suppose a fast skin regeneration to promote healing, the initial pain reduction and minimal scars forming. The development of new biopolymers-based wound dressings to ensure a proper healing process is nowadays a major challenge considering the incidence and consequences of burns. Our previously designed anti-inflammatory drug-loaded biopolymeric spongious matrices were initially tested by in vitro analysis and revealed proper morphological structure, swelling ability, degradation profiles and drug release patterns, indicating their potential use for burns treatment. Thus, the study aims to evaluate some collagen-sodium carboxymethylcellulose spongious matrices with or without mefenamic acid as non-steroidal anti-inflammatory drug in experimentally induced burns on Wistar rats, a frequently used animal model for the assessment of wounds healing. The treatment with the designed sponges promoted the wound healing compared to the classical treated control group. The sponges with mefenamic acid accelerated the healing process with a faster epithelial regeneration and a minimal scarring in comparison with the formulations containing no anti-inflammatory drug.
  • Küçük Resim
    Öğe
    SPONGIOUS FILLERS BASED ON COLLAGEN - HYDROXYAPATITE - EUGENOL ACETATE WITH THERAPEUTIC POTENTIAL IN BONE CANCER
    (Soc Stiinte Farmaceutice Romania, 2020) Vladu, Alina F.; Marin, Stefania; Neacsu, Ionela A.; Trusca, Roxana D.; Kaya, Madalina G. Albu; Kaya, Durmus A.; Popa, Ana-Maria
    The aim of this study was to develop and characterize composite materials based on collagen, hydroxyapatite and eugenol acetate as new filler biomaterial for the reconstruction of the tissue damage arising after the resection in case of bone cancer. Composite gels consisting of collagen and hydroxyapatite in different proportions (Coll:HAp - 100:0; 70:30; 40:60 - w/w) and 0.5% eugenol acetate were lyophilized and spongious fillers were obtained. The fillers were characterized by water absorption, enzymatic degradation and examined by optical and scanning electron microscopy, EDS, FT-IR spectroscopy while eugenol acetate release from the compositions was also studied. The results showed that the filler with optimal composition (Coll-HAp - 40:60 w/w) completely degrade over about 48 hours, the release capacity being longer during the 144 hours. The complex results obtained from physical-chemical, morphological and eugenol acetate release profile evaluation for the designed composite materials based on collagen and hydroxyapatite testify these formulations as drug delivery systems with potential applications as fillers in orthopaedic field in bone cancer.