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Subclinical left ventricular dysfunction in multiple sclerosis
(Blackwell Publishing, 2006) Akgul, Ferit; Mclek, Ismet; Duman, Taskin; Seyfeli, Ergun; Seydaliyeva, Tunzale; Yalcin, Fatih
Objectives: To investigate the left (LV) and right ventricular (RV) function in multiple sclerosis (MS) using standard echocardiography and Doppler tissue imaging (DTI). Materials and methods: A total of 41 patients with definite MS and 32 healthy controls were included in the study. Results: LV end-systolic dimension was increased and LV ejection fraction was decreased in MS patients compared with controls (P < 0.05). LV end-diastolic dimension was increased in MS patients, however, did not reach significance. Among DTI parameters, mitral annular peak early diastolic velocity to peak late diastolic velocity ratio (Em/Am) was decreased in MS patients, but not reach statistical significance. No significant differences in tricuspid annular Em/Am ratio was found between MS patients and controls. A statistically significant increase of DTI derived LV myocardial performance index was found in MS patients as compared with controls. RV myocardial performance index showed a tendency to be increased in MS patients, however, did not reach significance. Conclusions: These findings suggest subclinical LV dysfunction and preserved RV function in patients with MS.