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Öğe Can neurological soft signs be used to identify patients at risk of stroke in sickle cell disease?(Blackwell Publishing, 2006) Melek, I.; Duman, T.; Akgul, F.; Yalcin, F.[Abstract Not Available]Öğe Doppler tissue imaging of the left and right ventricular function in multiple sclerosis(Blackwell Publishing, 2006) Melek, I.; Duman, T.; Akgul, F.; Seyfeli, E.; Yalcin, F.[Abstract Not Available]Öğe Evaluation of selected cytokines, anti-oxidative system and lipid peroxidation in the brains of Brucella melitensis-infected rats(Blackwell Publishing, 2006) Melek, I.; Erdogan, S.; Duman, T.; Celik, S.; Kontas, T.; Aslantas, O.[Abstract Not Available]Öğe The Neuroprotective and Anti-inflammatory Effects of Diltiazem in Spinal Cord Ischaemia-Reperfusion Injury(Field House Publishing Llp, 2009) Fansa, I.; Altug, M. E.; Melek, I.; Ucar, E.; Kontas, T.; Akcora, B.; Atik, E.The protective effects of diltiazem were examined in a rabbit model of spinal cord ischaemia-reperfusion induced by infrarenal aortic occlusion for 30 min. In the diltiazem group (n = 6), an intravenous infusion (2 mu g/kg per min) was started 10 min before ischaemia induction; normal saline solution was infused in the control group (n = 6). Neurological function was assessed using modified Tarlov criteria 24 h after surgery. Plasma samples were analysed for interleukin (IL)-6 and IL-10. Spinal tissue was analysed for malondialdehyde, nitric oxide and reduced glutathione activities. Tarlov scores of the diltiazem-treated rabbits indicated significantly improved hind-limb motor function compared with the control group. The diltiazem group also had better quantitative and qualitative histopathological findings. Diltiazem infusion significantly reduced IL-6 levels 3 and 24 h after reperfusion compared with the control group. The mean IL-10 level in the diltiazem group was significantly higher than in the control group 24 h after reperfusion. It is concluded that diltiazem has cytoprotective and anti-inflammatory properties, leading to reduced spinal cord injury.
