Yazar "Melek, Ismet" seçeneğine göre listele
Listeleniyor 1 - 20 / 26
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe After stroke: Guidelines of Turkish Society of cerebrovascular diseases 2015(Turkish Society of Cerebrovascular Diseases, 2015) Bakar, Mustafa; Özdag, Mehmet Fatih; Melek, Ismet; Uludüz, Derya; Uzuner, Gülnur Tekgöl; Armagan, Onur; Özgen, MerihIn this section, recommendation of recent management approaches about post-stroke complications such as sensorymotor function impairment, drops, epilepsy, depression and dementia will be offered.Öğe Atypical Herpes Simplex Encephalitis With Extratemporal Involvement(Lippincott Williams & Wilkins, 2007) Okuyucu, Esra; Melek, Ismet; Duman, Taskin; Balci, Ali; Eraslan, TuraliHerpes simplex virus (HSV) is recognized as the most common cause of sporadic encephalitis among adults. The combination of magnetic resonance imaging, electroencephalography, and cerebrospinal fluid tests is usually diagnostic. In this article, we describe a case of atypical HSV encephalitis presenting a syndrome of febrile encephalopathy in the absence of focal neurological features, including mental and sensory disturbance, pyramidal signs, ataxia, and cranial nerve deficits, and in which magnetic resonance imaging demonstrated lesions restricted to the parietal and occipital lobes without typical localization of HSV encephalitis in the insula and inferior frontal lobe.Öğe A case of neurobrucellosis(Turkish Society of Cerebrovascular Diseases, 2011) Okuyucu, E. Esra; Yilmazer, Serkan; Dede, Hava Özlem; Melek, Ismet; Duman, TaşkinCausing serious morbidities and having so many different clinic formes are the clinical importances of brucellosis, which is a zoonotic infections. Neurobrucellosis, can appear with cranial nerve pathologies, optic stasis, menengitis, myelitis, radiculopathy, periferic neuropathy etc. The case is the woman who is 69 years old. Her complaints began as lumbar pain 3 years ago. She has not been able to stand unaided for a year. In the periventricular white matter chronic ischemic lessions, and in the right serebellar hemisfer an encephalomalasia were determined in the kranial MRI. Brucella tube agglitunation was 1/160(+). Clinic remission observed after neurobrucellosis treatment. The neurobrucellosis is a manifestation that can appear in a lot of different clinic formes; and it requires attention in the differential diagnoastics of several diseases.Öğe Causes of headache in childhood(2006) Incecik, Faruk; Sangün, Özlem; Ako?lu, Ertap; Melek, Ismet; Öksüz, Hüseyin; Duman, TaşkinHeadaches in childhood can be the result of serious organic events as well as the benign causes. In this paper, it is aimed to investigate the etiology of the headache complaint in childhood. This research is made retrospectively in 62 cases; 40 females and 22 males, who are 6-14 years old and admitted with the complaint of headache. The age of the beginning of the headache, duration, frequency, character, localization, intensity, accompanying factors, triggering factors, family history, physical and neurological examination, waters graphy, EEG, BBT and MRG datas are recorded. There were tension headache in 14 cases (22.6%), sinusitis in 11 (17.7%), migraine in 9 (14.5%), epilepsy in 6 (9.7%), posttraumatic headache in 5 (8.1%), headache related with eye disorders in 2 cases (6.4%), arachnoid cyst in 2 cases (3.2%), intracranial tumor in 1 case (3.2%) and unclassified headache in 10 cases (16.2%). In this study, the mostly seen causes of headaches in childhood are determined as tension headaches, migraine and sinusitis.Öğe Diagnosis of hemorrhagic stroke: Guidelines of Turkish society of cerebrovascular diseases - 2015(Turkish Society of Cerebrovascular Diseases, 2015) Melek, Ismet; Afsar, Nazire; Güngör, Levent; Gökçe, Mustafa; Utku, Ufuk; Kutluk, Kürsad; Uzuner, NevzatThe brief and current information about the diagnosis and subtypes of hemorrhagic stroke which constitutes of about 10- 15% of whole strokes will be offered.Öğe Effect of valproic acid usage on serum lipid profile in patients with epileps(2006) Incecik, Faruk; Sangün, Özlem; Melek, Ismet; Duman, TaşkinThe effect of antiepileptic drugs on serum lipid concentrations is well known. We investigate the effect of VPA usage on lipid profile. Serum lipid profiles of 25 epileptic patients followed with the VPA mono treatment and a control group consisting of 25 cases with similar sex ratio and ages were measured. The age and sex ratio of the cases in VPA using group and control group were not significantly different. According to control group it is detected that VPA usage has no effects on lipid profile. In the group of patients on VPA treatment, TK, HDL-C, LDL-C, VLDL-C, TG, TK/HDL and LDL/HDL levels were not affected from age, gender, serum level of VPA and the dose and duration of VPA treatment. Conclusion: Because different results were reported in several reports about the effect of VPA on serum lipid profile, which must be used in long term period for the treatment of epilepsy, no consensus has been made. So that we agreed that serum lipid profile must be regularly measured in patients using VPA.Öğe Effect of valproic acid usage on serum protein and immuneglobulin levels in epileptic patients(Aves, 2007) Incecik, Faruk; Sangun, Oziem; Melek, Ismet; Duman, TaskinPurpose: The aim of this study was to research the possible effect of VPA usage on serum protein and immunoglobulin (Ig) levels in epileptic patients. Material and methods: Twenty-five patients followed up after being diagnosed with epilepsy for a minimum of 6 months and were treated with VPA formed the experimental group. In all cases, serum protein and Ig levels, as well as VPA levels were measured. It has been investigated that in VPA using group whether serum protein and Ig levels affected VPA usage doses, treatment period, and levels in addition to the age and sex distribution. Results: There was no statistically significant difference in total protein, albumin, and Ig levels between VPA treatment and control groups. It was determined that in the epileptic group serum protein, albumin, Ig A, M, and G levels were not affected by the VPA serum levels, dosage or treatment duration or age and gender. Conclusion: While the treatment of VPA on epileptic patients, which requires long term usage, a regular follow up for serum proteins and immunoglobulins should be done and because of different results in different studies we suggest that more extensive studies should be performed for the definite results.Öğe Effects of valproic acid on hearing in epileptic patients(Elsevier Ireland Ltd, 2007) Incecik, Faruk; Akoglu, Ertap; Sanguen, Zlem; Melek, Ismet; Duman, TaskinObjective: Since some case reports about the ototoxicity of valproic acid have been published, probable adverse effects of valproic acid on hearing in the epileptic patients became a subject of interest. We wanted to investigate if ototoxicity occurs in pediatric epileptic patients using VPA for long terms. Methods: Twenty-one epileptic patients who have been using valproic acid at least for 6 months as monotherapy and 21 age-sex matched controls were included in the study. Audiometric tests were performed to all patients between the frequencies of 125 and 16,000 Hz. The effects of dosage, duration of therapy and serum levels of the VPA, on the audiometric results were investigated and the audiometric results were compared between the groups. Results: There was no difference in hearing thresholds of the groups between 125 and 16,000 Hz frequencies. Relation could not be established between the duration of VPA therapy, dosage of the drug, blood level of drug, age and sex of the patients and the auditory signs. Conclusions: Although we could not find any deleterious effect of VPA on hearing thresholds in our patient series, we think it is useful to perform audiometric tests at intervals while VPA is being used for tong periods, considering the presented case reports about sensorineural hearing loss. (c) 2007 Elsevier Ireland Ltd. All rights reserved.Öğe Evaluation of Respiratory Function in Patients with Epileptic Seizures(Kare Publ, 2021) Gokcek, Ozden; Huzmeli, Irem; Hallaceli, Hasan; Melek, Ismet; Okuyucu, Esra E.Objectives: Respiratory problems increase the number of epileptic seizures in individuals with epileptic seizures. This study aimed to determine the relationship between the number of seizures, sleep quality, and respiratory problems by evaluating the changes in respiratory parameters of epileptic patients. Methods: Thirty individuals aged 18-40 years with generalized epilepsy were included in the study. Demographic data, number of seizures per week, pulse and blood pressure measurements, age of seizures, and body mass index were recorded. Dyspnea with mMRC; pulmonary function test; level of physical activity (PA) with International physical activity assessment survey (IPAQ); mouth pressure measuring device with respiratory muscle strength; and sleep quality with Pittsburgh Sleep Quality Index (PSQI) were evaluated. Results: Thirty patients with epileptic seizures (mean age: 26.56 +/- 6.64 years) were included in the study. The mean; % maximal inspiratory pressure (MIP) 67.44, %Maximal expiratory pressure (MEP) 35.14, MIP 70.47, and MEP 62.24 cmH(2)O were found.The forced expiratory volumes/ forced vital capacity (FEV1/FVC) (41.01%) and FEV1 (62.50%; 2.56 L) was found lower than the standards. The positive correlation between the MEP, MIP, FEV1 (L), and severe PA was found. FVC with sitting, FEV1 (L) with moderate PA, and FEV1/FVC (%) with PSQI, sitting with educational status were positively correlated (p<0.05). There was a negative correlation between the %MIP and a systolic blood pressure; MIP, MEP (% and cmH(2)O) with diastolic blood pressure (p<0.05), and a positive correlation between the %MEP and SpO(2) (p<0.05). Conclusion: As a result, respiratory function, PA, and the sleep quality of individuals with epilepsy were affected. Respiratory muscle training, PA programs, and behavioral changes should be added to the medical treatment programs of these individuals.Öğe Evaluation of respiratory functions in patients with epileptic seizure(European Respiratory Soc Journals Ltd, 2019) Gokcek, Ozden; Huzmeli, Irem; Hallaceli, Hasan; Melek, Ismet[Abstract Not Available]Öğe Generalized anhidrosis(Riyadh Armed Forces Hospital, 2013) Yilmazer, Serkan; Okuyucu, Esra; Melek, Ismet; Duman, Taskin[Abstract Not Available]Öğe Increased QT dispersion in sickle cell disease(Karger, 2007) Akgul, Ferit; Seyfeli, Ergun; Melek, Ismet; Duman, Taskin; Seydaliyeva, Tunzale; Gali, Edip; Yalcin, FatihBackground: QT dispersion has been proposed to be a predictor of adverse outcomes in a variety of cardiac disease states. The objective of this study was to examine QT dispersion in patients with sickle cell disease (SCD) and to assess the effect of pulmonary hypertension (PHT) on QT dispersion. Methods: We performed Doppler echocardiographic assessments of pulmonary artery systolic pressure in 73 (mean age 18.5 +/- 8.0 years) steady-state SCD patients and 25 (mean age 19.6 +/- 7.2 years) healthy subjects. Resting 12-lead electrocardiogram was recorded and QT dispersion was calculated as the difference between maximum and minimum QT intervals. Bazett's formula was used to obtain a rate-corrected value of the QT interval (QTc). Results: Maximum QTc, minimum QTc and QTc dispersion were significantly increased in SCD patients compared to the control subjects (p < 0.0001, p < 0.05, p < 0.0001, respectively). Among SCD patients, patients with PHT had higher maximum QTc and QTc dispersion than patients without PHT (p < 0.0001). However, minimum QTc showed no significant differences between the two patient groups. Conclusion: QTc dispersion is significantly increased in SCD patients, especially those with PHT indicating regional inhomogeneity of ventricular repolarization. Copyright (c) 2007 S. Karger AG, Basel.Öğe Landau Kleffner syndrome, electrical status epilepticus in sleep and autistic regression: An overview of literature(Kare Publishing, 2012) Ekinci, Özalp; Işik, U?ur; Melek, IsmetLandau kleffner syndrome, electrical status epilepticus in sleep and autistic regression: an overview of literature Language regression in children is a challenging condition for clinicians since the diagnostic and therapeutic algorithms are not well established. Landau Kleffner syndrome (LKS), Electrical Status Epilepticus in Sleep (ESES) and Autistic Regression (AR) are three rare clinical entities in which langauage regression is present. LKS and ESES appear to be two points on the spectrum of epileptic syndromes characterized by severe paroxysmal EEG disturbance in sleep and regression. However, the available literature indicates that AR has many distinct features than LKS and ESES. For all of these three conditions, early recognition and treatment is crucial for favorable outcomes. Overnight EEG has an important diagnostic role for LKS and ESES. In this review, the clinical features, prognosis and treatment options of LKS, ESES and AR will be discussed.Öğe Multiple Sclerosis and Migraine; Coincidence or Co Morbidity?(Sage Publications Ltd, 2017) Duman, Taskin; Uluduz, Derya; Guntel, Murat; Demetgul, Ozcan; Melek, Ismet; Okuyucu, Esra[Abstract Not Available]Öğe Neuralgiform pain in a patient with sickle cell anemia and stroke(Turkish Society of Cerebrovascular Diseases, 2010) Okuyucu, E. Esra; Dede, Hava Özlem; Melek, Ismet; Duman, TaşkinSickle cell disease (SCD) is characterized by intermittent vaso-occlusive events and chronic hemolytic anemia. This genetic disease has mortal complications. Vaso-occlusive events result in tissue ischemia leading to acute and chronic pain as well as organ damage. People who hasn't have any organ damage, can live to fifth decade ,and 22% of these people die because of stroke. The woman is a carrier of sickle cell disease with complaints of neuralgia headache. No pathological symptom was encountered during the neuralogical exam. However subacute infarct on right corpus striatum and chronic infarct on the periventricular white matter were determined in the cranial MRI. Magnetic resonance venography of the brain indicated left sigmoid sinus thrombosis. The case is important because of having different cerebrovascular accident formes which were produced by sickle cell anemia.Öğe Neurological soft signs as the stroke risk in sickle cell disease(Tohoku Univ Medical Press, 2006) Melek, Ismet; Akgul, Ferit; Duman, Taskin; Yalcin, Fatih; Gali, EdipSickle cell disease (SCD) is a common form of hemoglobinopathy and is highly prevalent worldwide. Silent cerebral infarction, which represents infarction without clinical signs, is a risk factor for clinical stroke in patients with SCD. It is well known that silent infarction predisposes patients with SCD to overt stroke. The aim of the present study is to investigate the effect of silent infarction on neurological soft signs (NSS), which demonstrate subtle impairments in sensory integration, motor coordination and the sequencing of complex motor acts and to evaluate whether NSS can be used in clinical practice to evaluate the patients at risk of stroke in SCD patients with silent infarction. Fifty-nine SCD patients without any documented history of cerebrovascular accident and 28 healthy controls were included in this study. All the patients with SCD were evaluated with cerebral magnetic resonance imaging. We found that the NSS scores were significantly higher in patients with silent cerebral infarction than those in patients without silent infarction and control subjects (p < 0.05). Importantly, there was no significant difference in the NSS scores between the patients without silent infarction and control subjects. These results indicate that high NSS scores represnt an important finding for diagnosis of silent infarction in SCD patients. As silent infarction increases the risk for stroke in patients with SCD, NSS can be used to provide additional information in diagnosis of the patients with possible stroke risk during the course of SCD.Öğe Neuropathic pain's biopsychosocial effects(Springer-Verlag Italia Srl, 2017) Huzmeli, Esra Dogru; Melek, IsmetThe aim of our study is to understand neuropathic pain's social, psychological, and biological effects on the patients. All of the patients who were diagnosed with neuropathic pain (NP) by a neurologist were invited to participate in the study. The diagnoses were made based on the patients' history and symptoms and the results of their neurological examinations. Demographic characteristics (age and pain duration), diagnoses, and medical histories of the patients were recorded. Average daily pain intensity was measured using a 100-mm visual analogue scale (VAS). Quality of life was measured with RAND 36-Item Health Survey 1.0. Pittsburgh Sleep Quality Index (PSQI) was used to examine the quality of sleep, and Beck Depression Scale was used to examine depression status of the patients. A total of 26 patients (14 male, 12 female) between 33 and 79 years of age participated in the study. There were no dropouts from the study. Eleven (42.3%) patients' mood was normal and the others (57.7%) had different levels of depression. Two patients' (7.7%) quality of sleep was normal, but 24 (92.3%) of the patients' quality of sleep was poor. The patients' pain intensity was at an important and high value (VAS: 6.88). The most important result of this clinical study was that the biopsychosocial approach would be appropriate to understand and treat NP. The biopsychosocial approach to pain addresses psychological, sociocultural factors, and biomedical/physiological aspects. We wanted to draw attention to NP's psychological, emotional and sociocultural characteristics to show that the NP treatment can be applied within this framework.Öğe Pain, Sleep Quality and Emotional State of the Relationship between Disease Clinical Features in Patients with Multiple Sclerosis(Sage Publications Ltd, 2015) Dede, Hava Ozlem; Duman, Taskin; Ozer, Cahit; Melek, Ismet; Okuyucu, Esra[Abstract Not Available]Öğe Patients With Neuropathic Pain Have Poor Sleep Quality(Lippincott Williams & Wilkins, 2021) Guntel, Murat; Huzmeli, Esra Dogru; Melek, IsmetAlthough sleep disorders have been studied many times in neuropathic pain (NP), the effect of pain level, depression, and quality of life (QOL) on sleep quality in NP has been rarely investigated. In the present study, we aimed to investigate associations between possible quality of sleep (QOS) impairment and pain level, depression, and QOL. Average daily pain intensity, QOL, QOS, and depression status of the patients were evaluated using a 100-mm visual analog scale (VAS), the RAND 36-Item Health Survey 1.0, the Pittsburgh Sleep Quality Index, and Beck Depression Inventory (BDI), respectively. In 83.1% of patients QOS was found to be poor. We found that there was a significant difference between good and poor QOS in BDI, VAS, and RAND 36-Item Health Survey 1.0 scale's parameters, and patients with NP have poor sleep quality. Depression status is the main predictor for QOS, so pain level and QOL affect the QOS in NP. Physicians who aim healthy QOS must evaluate all characteristics of pain, depression status, and QOL in patients with NP.Öğe The phenomenology of autistic regression: subtypes and associated factors(Springer, 2012) Ekinci, Ozalp; Arman, Ayse Rodopman; Melek, Ismet; Bez, Yasin; Berkem, MeralThis study aimed to investigate the association of autistic regression (AR) and subtypes of AR with medical, developmental and psychiatric factors. Fifty-seven children with autistic spectrum disorders (ASD) were included in the study. Two types of AR are defined as regression after a normal social/language development (type 1) and regression as the worsening of previously reported autistic features (type 2). The frequency of history of AR was 56.1%. Male gender and sleep problems were found to be associated with a positive history of AR. The frequency of gastrointestinal complaints/diseases was higher in children with regression type 2 when compared to the children with regression type 1. Future studies with larger sample size and prospective design will contribute to clarifying the phenomenology and the associated factors of AR.
