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    CAFFEIC ACID PHENETHYL ESTER DECREASES THE LEVEL OF S-100B PROTEIN AFTER MIDDLE CEREBRAL AFTER OCCLUSION IN RABBITS
    (Univ Karachi, 2009) Serarslan, Yurdal; Bal, Ramazan; Altug, Muhammed Enes; Kontas, Tuenay; Melek, Ismet Murat
    Effects of caffeic acid phenethyl ester (CAPE) on the serum S-100B levels were studied as an index for brain damage after permanent middle cerebral artery (MCA) occlusion in rabbits. Twenty rabbits were divided into four groups (n=5): control, sham, non-treatment and CAPE. The right MCA was occluded using a microsurgical procedure with bipolar coagulation and was then transected in non-treatment and CAPE groups. The rabbits in the sham group underwent a surgical procedure but the MCA was not occluded. No surgery was performed in the control group. CAPE was administered after MCA occlusion at the dose of 10 mu g/kg, once a day intraperitoneally for 7 days in the CAPE group. Serum S-100B levels were determined on days 1, 2, 4 and 7. Serum S-100B level was significantly increased following permanent MCA occlusion. Posttreatment of CAPE significantly reduced the serum S-100B level. This study demonstrated that CAPE is capable of attenuating increased serum S-100B level induced by MCA occlusion in rabbits. CAPE may be useful as a neuroprotective agent.
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    Caffeic acid phenethyl ester decreases the level of S-100B protein after middle cerebral after occlusion in rabbits
    (2009) Serarslan, Yurdal; Bal, Ramazan; Altu?, Muhammed Enes; Kontaş, Tünay; Melek, Ismet Murat
    Effects of caffeic acid phenethyl ester (CAPE) on the serum S-100B levels were studied as an index for brain damage after permanent middle cerebral artery (MCA) occlusion in rabbits. Twenty rabbits were divided into four groups (n=5): control, sham, non-treatment and CAPE. The right MCA was occluded using a microsurgical procedure with bipolar coagulation and was then transected in non-treatment and CAPE groups. The rabbits in the sham group underwent a surgical procedure but the MCA was not occluded. No surgery was performed in the control group. CAPE was administered after MCA occlusion at the dose of 10?g/kg, once a day intraperitoneally for 7 days in the CAPE group. Serum S-100B levels were determined on days 1, 2, 4 and 7. Serum S-100B level was significantly increased following permanent MCA occlusion. Posttreatment of CAPE significantly reduced the serum S-100B level. This study demonstrated that CAPE is capable of attenuating increased serum S-100B level induced by MCA occlusion in rabbits. CAPE may be useful as a neuroprotective agent.
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    Comparative study of the volume of the temporal lobe sections and neuropeptide effect in Alzheimer's patients and healthy persons
    (Taylor & Francis Ltd, 2021) Petekkaya, Emine; Burakgazi, Gulen; Kus, Berna; Melek, Ismet Murat; Arpaci, Abdullah
    Aim The aim of this study was to make a volumetric comparison of some medial temporal lobe structures and neuropeptides between the patients of Alzheimer's disease (AD) and healthy individuals. Method The study comprised of a group of patients diagnosed with mild AD (n:15) and a Control group (n:15) (16 females, 14 males, mean age:72.90 +/- 4.50). Voxel-based morphometry and MRICloud analyses were performed on the MR images taken in 3D measurements of gray matter volumes of all subjects. Following a 10-minute hug test, blood samples were taken from all participants for oxytocin (OT) and arginine vasopressin (AVP) analyses. Results The patient group had a statistically lower right hippocampus volume (p = 0.004) and OT values (p = 0.028) than the Control group. OT signal values increased with a volume increase in the right parahippocampal gyrus (PHG_R), and OT conc. and AVP conc. values increased with increasing volume of the PHG_R. Conclusion It is suggested that the right hippocampus, right fusiform gyrus, left amygdala, left parahippocampal gyrus, and left entorhinal cortex atrophies can be used as predictors in the early diagnosis of AD. The positive correlation between PHG_R and neuropeptides showed the need to investigate the PHG and OT function more deeply.
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    Correlation of metal ions with specific brain region volumes in neurodegenerative diseases
    (Tubitak Scientific & Technological Research Council Turkey, 2023) Melek, Ismet Murat; Kus, Berna; Kaptan, Zulal; Petekkaya, Emine
    Background/aim: There are reports stating that deteriorations in metal homeostasis in neurodegenerative diseases promote abnormal protein accumulation. In this study, the serum metal levels in Alzheimer's disease (AD) and Parkinson's disease (PD) and its relationship with the cortical regions of the brain were investigated. Materials and methods: The patients were divided into 3 groups consisting of the AD group, PD group, and healthy control group (n = 15 for each). The volumes of specific brain regions were measured over the participants' 3 -dimensional magnetic resonance images, and they were compared across the groups. Copper, zinc, iron, and ferritin levels in the serums were determined, and their correlations with the brain region volumes were examined. Results: The volumes of left hippocampus and right substantia nigra were lower in the AD and PD groups, while the volume of the left nucleus caudatus (CdN) and bilateral insula were lower in the AD group compared to the control group. Serum zinc levels were lower in the AD and PD groups, while the iron level was lower in the PD group in comparison to the control group. In addition, the serum ferritin level was higher in the AD group than in the control group. Serum zinc and copper levels in the AD group were positively corre-lated with the volumes of the right entorhinal cortex, thalamus, CdN, and insula. Serum zinc and copper levels in the PD group showed a negative correlation with the left nucleus accumbens (NAc), right putamen, and right insula volumes. While the serum ferritin level in the PD group displayed a positive correlation with the bilateral CdN, putamen, and NAc, as well as the right hippocampus and insula volumes, no area was detected that showed a correlation with the serum ferritin level in the AD group. Conclusion: A relationship was determined between the serum metal levels in the AD and PD groups and certain brain cortical regions that showed volumetric changes, which can be important for the early diagnosis of neurodegenerative diseases.
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    Effect of tamsulosin therapy on lower urinary tract symptoms in Parkinson's disease
    (2008) Görür, Sadik; Melek, Ismet Murat; Okuyucu, Esra; Helli, Ali; Duman, Taşkin; Kiper, Ahmet Namik
    Introduction: The aim of this study is to evaluate the intensity of lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH) with and without Parkinson's disease (PD). We also investigated the efficacy of tamsulosin therapy in the management of the subjective and objective symptoms in these patients. Materials and Methods: This study included 80 (40 patients with and 40 without PD) clinically diagnosed BPH patients treated with tamsulosin. International Prostate Symptom score (IPSS), quality of life (QoL), maximum flow rate (Qmax) and post-void residual urine volume (PVR) were determined at baseline and after the 3 months of therapy. The PD group also evaluated with Unified Parkinson's Disease Rating Scale (UPDRS). All patients had received tamsulosin 0.4 mg/per day for 3 months period. The relationship between PD duration and UPDRS and mean changes of IPSS, QoL, Qmax and PVR after tamsulosin therapy were also investigated in PD group. Results: Three patients (7.5%) in PD group were discontinuied the therapy due to the severe hypotension attack. Initial data of IPSS, QoL, Qmax and PVR were different between two groups (p<0.001). After tamsulosin treatment, LUTS improved significantly in both groups (p<0.05). Improvement rates of the IPSS, QoL, Qmax and PVR were significantly higher in non-PD group (p<0.05). When relationship were investigated between PD duration and UPDRS and mean changes of IPSS, QoL, Qmax and PVR after tamsulosin therapy, all parameters were found in correlation except PVR. Conclusion: Tamsulosin therapy appears to useful in PD patient with BPH. But its efficacy is changed with PD duration and severity. After all, tamsulosin therapy can be given to these patients group with close follow-up.
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    EFFECT OF TAMSULOSIN THERAPY ON LOWER URINARY TRACT SYMPTOMS IN PARKINSON'S DISEASE
    (Aves, 2008) Gorur, Sadik; Melek, Ismet Murat; Okuyucu, Esra; Helli, Ali; Duman, Taskin; Kiper, Ahmet Namik
    Introduction: The aim of this study is to evaluate the intensity of lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH) with and without Parkinson's disease (PD). We also investigated the efficacy of tamsulosin therapy in the management of the subjective and objective symptoms in these patients. Materials and Methods: This study included 80 (40 patients with and 40 without PD) clinically diagnosed BPH patients treated with tamsulosin. International Prostate Symptom score (IPSS), quality of life (QoL), maximum flow rate (Qmax) and post-void residual urine volume (PVR) were determined at baseline and after the 3 months of therapy. The PD group also evaluated with Unified Parkinson's Disease Rating Scale (UPDRS). All patients had received tamsulosin 0.4 mg/per day for 3 months period. The relationship between PD duration and UPDRS and mean changes of IPSS, QoL, Qmax and PVR after tamsulosin therapy were also investigated in PD group. Results: Three patients (7.5%) in PD group were discontinuied the therapy due to the severe hypotension attack. Initial data of IPSS, QoL, Qmax and PVR were different between two groups (p<0.001). After tamsulosin treatment, LUTS improved significantly in both groups (p<0.05). Improvement rates of the IPSS, QoL, Qmax and PVR were significantly higher in non-PD group (p<0.05). When relationship were investigated between PD duration and UPDRS and mean changes of IPSS, QoL, Qmax and PVR after tamsulosin therapy, all parameters were found in correlation except PVR. Conclusion: Tamsulosin therapy appears to useful in PD patient with BPH. But its efficacy is changed with PD duration and severity. After all, tamsulosin therapy can be given to these patients group with close follow-up.
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    The effectiveness of the Epley maneuver for the treatment of BPPV and the role of nystagmus direction as an early indicator of successful treatment
    (2007) Ako?lu, Ertap; Okuyucu, Semsettin; Okuyucu, Esra; Melek, Ismet Murat; Duman, Taşkin; Da?li, Ali Safak
    OBJECTIVES: We investigated the role of the direction of nystagmus that might occur during the Epley maneuver as an early indicator for treatment success in benign paroxysmal positional vertigo (BPPV). PATIENTS AND METHODS: The study included 47 patients (24 males, 23 females; mean age 46+/-12 years; range 29 to 70 years) who underwent the Epley maneuver for BPPV. The occurrence and the direction of nystagmus were observed. RESULTS: Nystagmus occurred in 16 patients during the maneuver, being ipsilateral in nine patients and contralateral in seven patients. The treatment was successful in seven patients (77.8%) with ipsilateral nystagmus, whereas none of the patients with contralateral nystagmus benefited from the maneuver. While there was no significant relationship between ipsilateral nystagmus and the success of the treatment (p=0.625), a significant correlation was found between contralateral nystagmus and treatment failure (p=0.000). CONCLUSION: The occurrence of contralateral nystagmus during the Epley maneuver may be a sign of an unsuccessful result.
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    THE EFFECTS OF CALISTHENIC EXERCISES ON SLEEP QUALITY, FATIGUE, AND DEPRESSION IN ELDER ADULTS
    (Turkey Assoc Physiotherapists, 2023) Cetisli-Korkmaz, Nilufer; Kara-Cakici, Guzin; Dogru-Huzmeli, Esra; Huzmeli, Irem; Melek, Ismet Murat
    Purpose: The physical, psychological, even economic and environmental changes emerged with age cause problems in sleep. The lack of exercise habits could increase the incidence of unfavorable sleep disorders with depression and fatigue. The aim of this non-randomized controlled study was to investigate the considerable effects of calisthenic exercises on sleep disorders, depression, and fatigue in elder adults. Methods: The study was conducted at Pamukkale University and Hatay Mustafa Kemal University. Sixty-two individuals participated in the study between May 2018-October 2019. While the Calisthenic Group (n=32) performed calisthenic exercises for 30-45minutes/session and 3days/6-weeks, and Control Group (n=30) did not performed. Fatigue, depression, and sleep quality levels were assessed using the Fatigue Severity Scale (FSS), Beck Depression Scale (BDI), and Pittsburgh Sleep Quality Index (PSQI), respectively. Results: Statistically significant differences among FSS (p=0.001), BDI (p=0.022), and PSQI (p=0.006) scores were found in the Calisthenic Group after the intervention, while there were differences only in fatigue (p=0.035) and total sleep quality (p=0.035) for the Control Group. We found that the Calisthenic Group's PSQI latency, PSQI sleep duration and PSQI total scores decreased in post-treatment. Both fatigue severity (p=0.001) and depression levels (p=0.001) were highly correlated with PSQI-subscores, except for sleep duration subscore (FSS p=0.934, BDI p=0.276). Conclusion: Regular calisthenic exercise programs may enable elders to better manage changes in the aging process. Physiotherapists should consider including calisthenic exercises in the rehabilitation programs for its effects on all parameters of sleep, fatigue, mental and emotional status in this population.
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    Leg ulcer, pulmonary hypertension and silent cerebral infarct in two patients with sickle cell disease
    (Turkish Society of Cerebrovascular Diseases, 2006) Serarslan, Gamze; Melek, Ismet Murat; Akgül, Ferit; Serarslan, Yurdal; Duman, Taşkin
    Sickle cell disease is an inherited hemoglobinopathy and polymerization of deoxygenated HbS lead to clinical manifestations of the disease. The stroke rate in sickle cell disease patients with silent cerebral infarct is 14-fold higher than in those with normal MRI. We present two patients of sickle cell disease with leg ulcer, pulmonary hypertension and silent cerebral infarct and the only symptom was the leg ulcer.
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    Macrocephaly and bitemporal arachnoid cysts not associated with glutaric aciduria type I in a child
    (Turkish Neurosurgical Soc, 2008) Serarslan, Yurdal; Melek, Ismet Murat; Sangun, Ozlem; Akcora, Buelent; Akdemir, Goekhan
    A 45-month-old child who had bitemporal arachnoid cysts and macrocephaly unrelated to glutaric aciduria type 1 (GA 1) was reported. The patient was admitted to the emergency unit after head trauma at 11 months of age. CT and MRI showed bitemporal arachnoid cysts (BACs). Acylcarnitine profile was normal in serum using tandem mass spectrometry. Urine and blood screening tests were within normal range for metabolic disorders. There were no unusual organic acids in urine and blood samples. No additional clinical findings of metabolic disorders such as GA I developed during follow-up. The majority of children affected with GA 1 have macrocephaly and BACs on CT or MRI. These signs should alert neurosurgeons to the possibility of GA 1. Neurosurgeons evaluating patients with head trauma or suspected non-accidental head injury should include GA 1 in the differential diagnosis of BACs associated with macrocephaly, and an evaluation should be performed.
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    Possible role of endocannabinoids in olfactory and taste dysfunctions in Alzheimer's and Parkinson's patients and volumetric changes in the brain
    (Elsevier Sci Ltd, 2022) Petekkaya, Emine; Kus, Berna; Dogan, Serdar; Bayarogullari, Hanifi; Mutlu, Turay; Melek, Ismet Murat; Arpaci, Abdullah
    The purpose of this study is to determine the volumes of primary brain regions associated with smell and taste in Alzheimer's and Parkinson's patients and healthy controls using MR imaging and examine volumetric changes in comparison to smell/taste questionnaire and test results and endocannabinoid (EC) levels. The study included 15 AD patients with mild cognitive dysfunction scored as 18 <= MMSE <= 23, 15 PD patients with scores of 18 < MoCA < 26 and 18 <= MMSE <= 23, and 15 healthy controls. A taste and smell questionnaire was given to the participants, and their taste and smell statuses were examined using the Sniffin' Sticks smell identification test and Burghart Taste Strips. EC levels were analyzed in the blood serum samples of the participants using the ELISA method. The volumes of the left olfactory bulb (p = 0.001), left amygdala (p = 0.004), left hippocampus (p = 0.008), and bilateral insula (left p = 0.000, right p = 0.000) were significantly smaller in the Alzheimer's patients than the healthy controls. The volumes of the left olfactory bulb (p = 0.001) and left hippocampus (p = 0.009) were significantly smaller in the Parkinson's patients than the healthy controls. A significant correlation was determined between volume reduction in the left Rolandic operculum cortical region and taste dysfunction. EC levels were significantly higher in both AD (p = 0.000) and PD (p = 0.006) in comparison to the controls. Our results showed that volumetric changes occur in the brain regions associated with smell and taste in Alzheimer's and Parkinson's patients. It was observed that ECs played a role in these volumetric changes and the olfactory and taste dysfunctions of the patients.
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    Relationship of restless legs syndrome with blood parameters
    (Cukurova Univ, Fac Medicine, 2022) Guntel, Murat; Uysal, Alper; Melek, Ismet Murat
    Purpose: We aimed to investigate the factors affecting the etiopathogenesis by comparing the restless legs syndrome patients with the healthy control group in terms of some laboratory parameters. Materials and Methods: Patients who were diagnosed with restless legs syndrome were included in the study. A control group that was similar in terms of age and gender was formed. Both groups were compared in terms of iron, ferritin, iron-binding capacity, folate, vitamin B12, vitamin D, calcium, magnesium, ALT, AST, hemogram, creatinine, fasting blood sugar, and thyroid hormone levels. Results: 37 patients with restless legs syndrome and 41 controls were included in the study. In the restless legs syndrome group hemoglobin, ferritin, iron, fasting blood sugar, vitamin D, and fT4 values were 12.7 (10.3-16.0) g/dL, 37.3 (3.7-89.4) mg/L, 62 (21-195) mu g/dL, 96 (65-250) mg/L, 11.26 (4.20-41.57) ug/L and 1.24 (0.73-2.14) mu g/dL respectively, they were 14.8 (12.3-16.1) g/dL, 56 (9-189) mg/L, 90 (30-245) mu g/dL, 91 (70-107) mg/L, 17.31 (5.73-32.90) mu g/L and 1.08 (0.63-2.04) mu g/dL respectively in the control group.There were statistically significant differences between the groups in terms of hemoglobin, ferritin, iron, fasting blood sugar, vitamin D, and fT4 levels. Conclusion: Hemoglobin and iron parameters, vitamin D levels, fasting blood sugar and T4 levels should be evaluated in patients with restless legs syndrome and should be replaced if necessary. Correction of deficiencies may be beneficial for patients' clinics.