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Öğe Beneficial effect of erdosteine on methotrexate-induced testicular toxicity in mice(Sage Publications Inc, 2010) Oktar, Sueleyman; Gokce, Ahmet; Aydin, Mehmet; Davarci, Muersel; Meydan, Sedat; Ozturk, Oktay Hasan; Koc, AhmetMethotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. Methotrexate can cause serious or life-threatening side effects on liver, lungs, kidneys, and immune system. Methotrexate chemotherapy causes testicular damage in humans. The aim of this study was to investigate the possible protective role of erdosteine on testicular toxicity of methotrexate in mice. Twenty-six male mice were divided into four groups as follows: group 1, control; group 2, erdosteine-treated; group 3, methotrexate-treated; and group 4, methotrexate + erdosteine treated. On the first day of experiment, a single dose of methotrexate was intraperitoneally administered to groups 3 and 4, although a daily single dose of erdosteine was orally administered to group 2 and 4 for 7 days. At the end of the experiment, the testes of the animals were removed and weighed. The levels of total antioxidant capacity and total oxidative stress, and myeloperoxidase activity in the methotrexate group were higher than the control group (p<0.05). Lipid peroxidation levels were not changed in methotrexate group compared with control group. In conclusion, erdosteine could effectively protect the testes in methotrexate-induced toxicity.Öğe Effects of lemon essential oil aroma on the learning behaviors of rats(Riyadh Armed Forces Hospital, 2010) Ogeturk, Murat; Kose, Evren; Sarsilmaz, Mustafa; Akpinar, Burhan; Kus, Ilter; Meydan, Sedat[Abstract Not Available]Öğe Effects of testosterone on orchiectomy-induced oxidative damage in the rat hippocampus(Elsevier, 2010) Meydan, Sedat; Kus, Ilter; Tas, Ufuk; Ogeturk, Murat; Sancakdar, Enver; Dabak, Durrin Ozlem; Zararsiz, IsmailThe aim of this study was to investigate the morphological changes of the hippocampus after orchiectomy and the protective effects of testosterone on these changes. Animals were divided into 3 groups. The rats in group I were used for sham-orchiectomy. Orchiectomy was performed on the rats in group II. The rats in group III were administrated testosterone propionate 0.5 mg/kg/day for 30 days after the orchiectomy. Some of the hippocampal tissues were used for determination of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) enzyme activities, and malondialdehyde (MDA) levels. The remaining hippocampal tissue specimens were stained with routine histological methods and examined under the light microscope. Additionally, the samples were immunohistochemically stained by using avidin-biotin-peroxidase for determination of bax immunoreactivity. The SOD and GSH-Px enzyme activities of the hippocampus were decreased, and MDA levels were increased in group II rats compared to the sham-orchiectomy group. In the light microscopic evaluation of the tissue specimens from group II, significant increases were detected in the number of picnotic cells and in bax immunoreactivity compared to the sham-orchiectomy group. However, an increase was observed in activities of SOD and GSH-Px enzymes and a decrease of the MDA levels in animals with orchiectomy, but having externally administered testosterone. It was determined that the increase of bax immunoreactivity and histopathological changes in this group were regressed by testosterone. The results of our study revealed that orchiectomy-induced oxidative damage and morphological changes in the hippocampal tissue were suppressed by testosterone. (C) 2010 Elsevier B.V. All rights reserved.Öğe Hepatotoxic activity of toluene inhalation and protective role of melatonin(Sage Publications Inc, 2011) Tas, Ufuk; Ogeturk, Murat; Meydan, Sedat; Kus, Ilter; Kuloglu, Tuncay; Ilhan, Necip; Kose, EvrenThis study was designed to investigate the harmful effects of toluene inhalation in the liver of rats and possible protective effects of melatonin on these detrimental effects. For this purpose, 21 adult male Wistar-albino rats were randomly divided into three equal groups. Animals in group I were used as control. The rats in group II were exposed to toluene (3000 ppm/1 hour/day) for 4 weeks, while the rats in group III were treated with melatonin (10 mg/kg/day, intraperitoneally [ip]) plus toluene inhalation. At the end of the experimental period, liver and blood samples were taken from the decapitated animals. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin and albumin levels were determined. Liver tissue sections were stained with routine histological methods and examined under the light microscope. In addition, the sections were immunohistochemically stained using avidin-biotin-peroxidase method for determination of apoptosis. The liver tissue activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and malondialdehyde (MDA) levels were also measured. Toluene inhalation significantly increased serum ALT, AST and tissue MDA, and decreased serum albumin, but did not affect serum ALP, total bilirubin levels and tissue SOD, GSH-Px and CAT activity when compared with controls. The increases in tissue MDA and serum ALT and AST levels induced by toluene inhalation were significantly inhibited by melatonin treatment. In light microscopic observations of tissues from toluene-inhaled rats, massive hepatocyte degeneration, ballooning degeneration and mild pericentral fibrosis were observed. Bax immune reactivity was also increased significantly. Melatonin treatment decreased the balloon degeneration, fibrosis and Bax immune reactivity in the liver of toluene-inhaled rats. In view of the present findings, it is suggested that melatonin has hepatoprotective effects against toluene toxicity via primarily antioxidative properties.Öğe Mustafa Kemal Üniversitesi Tayfur Ata Sökmen Tıp Fakültesi Acil Servise kırık nedeniyle başvuran hastalarda kırık dağılımı ve sıklığı(2009) Zararsız, İsmail; Kaya, Ergün; Savaş, Nazan; Meydan, Sedat; Davran, Ramazan; Tutanç, Murat; Duru, MehmetBu çalışmada 2007 Ekim - 2008 Ekim tarihleri arasında Mustafa Kemal Üniversitesi Tayfur Ata Sökmen Tıp Fakültesi Acil servise başvuran kemik kırığı vakaları incelendi. Kırığın anatomik lokalizasyonu, kırık tipi, yaş gruplarına göre dağılımı ve kırığa yol açan etkenler araştırıldı. Ayrıca darp, aile içi şiddet, kırığa eşlik eden osteoporoz gibi hastalıkların olup olmadığı incelendi. Kırık vakalarının kadınlara (% 38.7) göre erkeklerde daha yüksek (% 61.3) olduğu görüldü. Ayrıca kırıklar erişkinlerde % 63 oranında tespit edildi, bu oran çocukluk çağı kemik kırıklarında daha düşük (% 37) seviyede idi. Çocuklarda üst ekstremite kırıkları daha sık görülürken, erişkinlerde alt ekstremite kemik kırıkları daha yüksek oranda tespit edildi. Çocuklarda en fazla kırılan kemik radius, onu humerus ve ulna takip ederken, erişkinlerde en fazla kırılan kemik femur idi. Kırık sebepleri arasında yüksekten düşme, trafik kazaları ve spor yaralanmaları ön sıralarda yer alıyordu. Kemik kırıklarının belirlenmesine yönelik yapılan bu çalışmada, elde edilen sonuçların insanların maruz kaldığı travmaların azaltılması ve/veya önlenmesine yönelik çalışmalarda önemli katkı sağlayacağını düşünmekteyiz.Öğe The protective effects of caffeic acid phenethyl ester against toluene-induced nephrotoxicity in rats(Sage Publications Inc, 2016) Meydan, Sedat; Nacar, Ahmet; Ozturk, Hasan Oktay; Tas, Ufuk; Kose, Evren; Zararsiz, Ismail; Yilmaz, NigarCaffeic acid phenethyl ester (CAPE) has antioxidant and anti-inflammatory properties. The aim of this study is to examine the negative effects of toluene on kidney tissues and functions and to investigate the protective effects of CAPE against toluene-induced nephrotoxicity in rats. A total of 21 male Wistar rats were divided into three groups of equal number in each. The rats in group I were the controls. Toluene was intraperitoneally injected into the rats in group II with a dose of 500 mg/kg. Rats in group III received CAPE daily while exposed to toluene. After 14 days of experimental period, all rats were killed by decapitation. Enzymatic activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) and malondialdehyde (MDA) levels were studied in the rat kidneys. Blood urea nitrogen (BUN) and serum creatinine levels were measured for renal function. The CAT and SOD enzyme activities and serum creatinine levels were significantly increased in rats treated with toluene when compared with the controls. But GSH-Px activity, MDA, and BUN levels showed statistically nonsignificant changes. However, increased CAT and SOD enzyme activities and decreased serum creatinine levels were detected in the rats that received CAPE while exposed to toluene. The GSH-Px activity and MDA and BUN levels in the same group did not show statistically significant changes. The results of our study demonstrated that toluene damages kidney tissue and is a nephrotoxic substance. CAPE was able to prevent the renal damage as antioxidant, antitoxic, and nephroprotective agent.Öğe Protective effects of omega-3 essential fatty acids against formaldehyde-induced cerebellar damage in rats(Sage Publications Inc, 2011) Zararsiz, Ismail; Meydan, Sedat; Sarsilmaz, Mustafa; Songur, Ahmet; Ozen, Oguz Aslan; Sogut, SadikThis study aimed to investigate changes in the cerebellum of formaldehyde-exposed rats and the effects of omega-3 fatty acids on these changes. The study involved 21 male Wistar-Albino rats which were divided into three groups. The rats in Group I comprised the control group. The rats in Group II were injected with intraperitoneal 10% formaldehyde every other day. The rats in Group III received omega-3 fatty acids daily while exposed to formaldehyde. At the end of the 14-day experimental period, all rats were killed by decapitation and the cerebellum removed. The activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), xanthine oxidase (XO), and malondialdehyde (MDA) levels were determined in cerebellum specimens by using spectrophotometric methods. In our study, levels of SOD and CAT were significantly decreased, and GSH-Px, XO, MDA levels were significantly increased in rats treated with formaldehyde compared with those of the controls. Whereas, it was seen that there was an increase in SOD and CAT enzyme activities and decrease in MDA, XO, and GSH-Px levels in rats administered to omega-3 fatty acids with exposure of formaldehyde. It was determined that exposure of formaldehyde increased free radicals in cerebellum of rats and this increase was prevented by administration of omega-3 fatty acids.Öğe Salt and Nitric Oxide Synthase Inhibition-Induced Hypertension: Kidney Dysfunction and Brain Anti-Oxidant Capacity(Taylor & Francis Inc, 2010) Oktar, Suleyman; Ilhan, Selcuk; Meydan, Sedat; Aydin, Mehmet; Yonden, Zafer; Gokce, AhmetThe specific aim of this study was to examine the effects of salt-loading on kidney function and brain antioxidant capacity. Wistar rats were divided into four groups: Control rats were given normal drinking water and no drug treatment for 2 weeks. LNNA group: rats were given normal drinking water and the nitric oxide (NO) inhibitor NG-nitro-L-arginine (L-NNA), 3 mg/kg/day. LNNA + Salt group: rats were given drinking water containing salt 2% and 3 mg/kg L-NNA. Salt group: rats were given drinking water containing salt 2% and no drug treatment. Basal blood pressure and the levels of serum BUN, creatinine, uric acid, cortisol, electrolyte, serum antioxidant capacity, and oxidative stress were measured. NO, superoxide dismutase (SOD), and catalase (CAT) levels were measured in the hypothalamus, brainstem, and cerebellum. Salt overload increased the blood pressure of the LNNA + Salt group. Salt-loading enhanced BUN, creatinine, sodium retention. High salt produced an increase in uric acid levels and a decrease in cortisol levels in serum. Additionally, the oxidative stress index in serum increased in the LNNA + Salt group. Salt-loading enhanced brain NO levels, but not SOD and CAT activity. L-NNA increased brain SOD activity, but not CAT and NO levels. In conclusion, salt-loading causes hypertension, kidney dysfunction, and enhances oxidative stress in salt-sensitive rats.Öğe Solunum yoluyla formaldehit ve lavanta uygulanan sıçan testislerinin değerlendirilmesi ; bir histolojik çalışma(2010) Köse, Evren; Sarsılmaz, Mustafa; Meydan, Sedat; Pekmez, Hıdır; Dabak, Durrin Özlem; Kavaklı, Ahmet; Ögetürk, MuratAmaç: Çalışmamızda, solunum yolu ile uygulanan formaldehit’in sıçan testislerinde yaptığı hasar histolojik olarak araştırıldı. Aynı zamanda, bu hasarlara karşı aromaterapi uygulamalarında sık kullanılan lavanta yağının muhtemel koruyucu etkileri de incelendi. Gereç-Yöntem: Bu amaçla, 21 adet Wistar-Albino cinsi erkek sıçan kullanıldı. Grup I’deki sıçanlar kontrol olarak kullanılırken, Grup II’deki sıçanlar, 35 gün boyunca solunum yoluyla formaldehit’e (10 ppm/1saat) maruz bırakıldı. Grup III’deki sıçanlara ise formaldehit uygulamasının yanı sıra saf lavanta yağı (1ml/1saat) yine solunum yoluyla verildi. Uygulama sonunda hayvanlar sakrifiye edildi ve histolojik incelemeler için testisler çıkarıldı. Çalışmada, tubuli seminiferi contorti çapları, Leydig hücre sayıları ve çekirdek hasarlı Leydig hücreleri incelendi. Bulgular: Formaldehit’e maruz kalan sıçanlar kontrol grubu ile karşılaştırıldığında, tubül çapları ve Leydig hücre sayılarında azalma, çekirdek hasarlı Leydig hücrelerinde ise artma tespit edildi. Ayrıca tubül duvarlarında atrofik değişiklikler gözlendi. Formaldehit maruziyetiyle birlikte lavanta yağı uygulanan grupta ise, formaldehit maruziyetine bağlı olarak testiste gelişen histolojik değişikliklerin düzelmiş olduğu belirlendi. Sonuç: Solunum yolu ile formaldehit maruziyetine bağlı olarak testiste önemli histolojik hasarların meydana geldiği ve bu hasarlara karşı lavanta yağının koruyucu özellik gösterdiği tespit edildi.Öğe Telescopic aortic arch a new entity in marfan syndrome(2011) Arslan, Muhammet Mustafa; Akçan, Ramazan; Zararsız, İsmail; Meydan, SedatTeleskopik arkus aorta, Marfan sendromunda aortik diseksiyon sonu- cu oluşabilen ve daha önceden rapor edilmemiş bir antitedir. Burada bir adli otopside tespit edilen ve kronik aort diseksiyonuna ikincil ilk teleskopik arkus aorta olgusu bildirilmiştir. 20 yaşında bir erkekte as- sendan aorta rüptüründen kaynaklanan kalp tamponadı sonucu ani ölüm olgusu sunulmuştur. Otopside, serbest ve pıhtılı kandan oluşan 800 cc’lik bir hemoperikardium olduğu dikkati çekmiştir. Assendan torasik aortanın dilate olduğu ve ön duvar mediailinde 1,2 cm’lik tam kat duvar rüptürü olduğu tespit edilmiştir. Aort muayenesinde, arkus aorta içerisinde bir tüp gibi yerleşmiş ikinci bir arkus aorta olduğu dikkati çekmiştir. İçteki bu ikinci arkın aort kapaklarının 2,5 cm üzeri- nden başladığı ve desseden aorta başlangıcında sonlandığı; ayrıca 10 cm uzunluğunda ve 2 cm çapında olup trunkus brakiosefalikus, sol karotis kommonis ve sol subklavian arterle ilişkili olduğu saptanmıştır.Öğe Telescopic aortic arch: A new entity in marfan syndrome(TIP ARASTIRMALARI DERNEGI, 2011) Arslan, Muhammet Mustafa; Akçan, Ramazan; Zararsiz, Ismail; Meydan, SedatTelescopic aortic arch is a consequence of aortic dissection in Marfan's syndrome, which has not been reported previously. This paper presents the first case of telescopic aortic arch secondary to chronic aortic dissection, as an incidental finding of a forensic autopsy. Here we present a sudden death of a 20 years old male due to cardiac tamponade sourcing from the rupture of ascending aorta. At autopsy, there was a haemopericardium of 800 cc, which comprised blood and clot. The ascending thoracic aorta was dilated and a 1.2 cm ragged linear complete rupture was noticed on the medial side of the front wall of ascending aorta. Examination of aorta showed a second/inner aortic arch just as a tube lying inside the aortic arch. The inner aortic arch was arrised 2.5 cm above aortic valves and lasted at the beginning of the descending aorta. It was 10 cm in length with a lumen 2 cm in diameter and was associated with truncus brachiosephalicus, left common carotid, and left subclavian arteries.Öğe Tolüen solutulan sıçanların karaciğerinde ghrelin ekspresyonu(2009) Taş, Ufuk; Ögetürk, Murat; Meydan, Sedat; Sapmaz, Irmak Hilal; Dabak, Dürrin Özlem; Kuloğlu, Tuncay; Sarsılmaz, MustafaTolüen endüstride çok sık kullanılan, bağımlılık yapıcı ve toksik etkileri olan aromatik bir hidrokarbondur. Ghrelin ise yakın zamanda keşfedilen birçok doku gibi karaciğer dokusunda da bulunan çok fonksiyonlu bir hormondur. Bu çalışmada, karaciğer üzerine toksik etkileri olduğu bilinen tolüenin deneysel olarak sıçanlara uygulanması sonucunda karaciğer dokusunda ghrelin ekspresyonunun immünohistokimyasal yöntemlerle araştırılması amaçlanmıştır. Bu amaçla, 14 adet Wistar-Albino cinsi erkek sıçan iki eşit gruba ayrıldı. Grup I'deki sıçanlar kontrol olarak düzenlendi. Grup Il'deki sıçanlar, dört hafta boyunca solunum yoluyla tolüen'e (3000 ppm/lsaat/gün) maruz bırakıldı. 30. günün sonunda tüm ratlar dekapite edilerek karaciğer dokuları ışık mikroskobu takibi için %10'luk nötral formalin ile fikse edilip, rutin histolojik takip serilerinden geçirilerek parafin bloklara gömüldü. Ghrelin dağılımını belirlemek amacıyla parafin bloklardan 5 µm kalınlığında kesitler polilizinli lamlara alındı. Avidin-biotin-peroksidaz yöntemi ile ghrelin immünreaktivitesi belirlendi. Karaciğer dokusunda ghrelin immünreaktivitesi Grup I'de şiddetli (+3), Grup Il'de bazı hepatositlerde hafif (+1) olarak izlenirken, bazı hepatositlerde ise immünreaksiyon gözlenmedi. Negatif kontrol için yapılan boyamalarda, hepatositlerde herhangi bir immünreaktivite görülmedi. Pozitif kontrol olarak ise, mide dokusunda ghrelin immünreaktivitesi belirlendi. Bu çalışmanın sonucunda, tolüen maruziyetinin karaciğer dokusunda ghrelin ekspresyonunu azalttığı belirlendi.
