Yazar "Mutaf, Mehmet" seçeneğine göre listele

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    The Effect of Coenzyme Q10 (Ubiquinone) on Random Pattern Skin Flap Survival in Rat Model
    (Lippincott Williams & Wilkins, 2016) Can, Asli; Temel, Metin; Dokuyucu, Recep; Mutaf, Mehmet
    Background: In this study, the effect of coenzyme Q(10) (CQ(10)) on flap survival was investigated. Methods: FiftyWistar Albino rats were divided into 5 groups. The survival rates of the skin flaps were assessed 10 days after complete elevation of the flaps. Regions of survival and necrosis were drawn on transparent acetate sheets and scanned into a computer. Tissue samples were assessed histopathologically after staining with hematoxylin-eosin, vascular endothelial growth factor staining and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-Biotin Nick End-labeling staining. To evaluate the antioxidant effect of CQ(10); malondialdehyde, nitric oxide levels were measured. Results: Viable flaps area was found higher in groups 3 and 4 as compared to groups 1, 2, and 5. In terms of vascular proliferation, elevated angiogenesis was observed in pathological specimens of groups 3 and 4 as compared to groups 1, 2, and 5. Malondialdehyde levels in groups 3 and 4 were found to be significantly decreased as compared to groups 1, 2 and 5 (P < 0.05). Moreover, serum levels of CQ(10) were found significantly increased in groups 3 and 4 (P < 0.05). Conclusions: In conclusion, CQ(10) significantly improves flap viability in rat model, and the highest levels of serumCQ(10) can be obtained by oral administration.
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    A New Surgical Technique for Closure of Pilonidal Sinus Defects: Triangular Closure Technique
    (Int Scientific Literature, Inc, 2017) Mutaf, Mehmet; Temel, Metin; Koc, Mustafa Nihat
    Background: We present a clinical experience with a new local flap procedure, namely the triangular closure technique, for reconstruction of sacrococcygeal skin defects resulting from excision of the pilonidal sinus. Material/Methods: In this technique, the defect is surgically converted to a triangle in shape. Then, the triangular defect is closed by transposition of 2 skin flaps designed in an unequal z-plasty manner. Over 6 years, this technique has been used for closure of defects of chronic pilonidal sinus disease in 27 patients (6 females, 21 males). The size of the defect ranged between 3.5 cm and 12 cm in dimension. Results: A tension-free defect closure was obtained in all patients. All flaps except one healed with no complications. A mean follow-up of 3.62 +/- 1.77 months revealed aesthetically and functionally acceptable results with the obliteration of the natal cleft in all patients. No recurrence was observed in the follow-up period. Conclusions: The triangular closure technique was found to be a useful technique for the treatment of pilonidal sinus with favorable results regarding the time before return to work.
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    A New Technique for Total Reconstruction of the Lower Lid
    (Lippincott Williams & Wilkins, 2017) Mutaf, Mehmet; Temel, Metin
    Background: Although several methods have been described for total lower eyelid reconstruction, it remains as a major challenge in reconstructive surgery. Here, we present a new technique, the Mutaf unequal Z-plasty procedure for reconstruction of defects of the lower eyelid. Methods: In this technique, 2 skin flaps designed in an unequal Z-plasty manner are used to provide skin coverage. Except for 2 patients whose additional upper eyelid defects were closed with Fricke flap, all patients were reconstructed with Mutaf unequal Z-plasty procedure. The conjunctival and tarsal defects are reconstructed with composite chondrocutaneous from the ear, mucochondral grafts, harvested from the nasal septum. In over 12 years, this new technique was used in 24 patients, 13 men and 11 women, with total and subtotal lower eyelid defects that resulted from excision of basal cell carcinomas. The age range of the patients was between 45 and 72 years. Results: There was no complication such as ocular irritation or postoperative epiphora because of ectropion or entropion; all patients healed uneventfully. A mean follow-up of 4.7 +/- 2.15 years (between 1 and 9 years) revealed a functionally and cosmetically satisfactory total lower eyelid reconstruction in all patients. Conclusions: This new technique seems to be a useful alternative for reconstruction of total and subtotal lower eyelid defects. The procedure seems to be superior since it requires considerably shorter operating time with no risk of flap failure. Moreover, this technique offers an excellent color and textural match for the reconstruction of total and subtotal lower eyelid defects extending the infraorbital area.
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    A novel tumor suppressor gene in basal cell carcinoma: inhibition of growth factor-2
    (Springer, 2015) Temel, Metin; Turkmen, Arif; Dokuyucu, Recep; Cevik, Cengiz; Oztuzcu, Serdar; Cengiz, Beyhan; Mutaf, Mehmet
    In loss of heterozygosity (LOH) studies at the chromosome 4q22-35 region, it was shown that the amount of deletion was high in basal cell carcinoma (BCC). It has been proposed that genes located in this chromosomal region could be tumor suppressor genes in BCC. It has been thought that deletions in the ING2 gene located in the same region can play a role in the pathophysiology of BCC and that deletions occurring in this region may influence the level of ING2 expression in BCC. Tumoral and non-tumoral tissues from 75 patients with BCC (45 men and 30 women) were included to the study. Lesions were excised by a surgical margin of 0.5 cm. After excision, RNA was isolated from tumoral and non-tumoral tissue samples. ING2 messenger RNA (mRNA) expression level was determined in tumoral and non-tumoral tissues by the real-time polymerase chain reaction (RT-PCR). It was detected that ING2 mRNA expression level decreased in tumoral tissues when compared to non-tumoral tissues from BCC patients (p = 0.0001). It was found that expression levels of this gene were comparable among patients with primary, recurrent, or multiple BCC. It is thought that ING2 gene expression level could contribute to the development of BCC but not be associated with the stage and the prognosis of the tumor.