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Öğe Does somatostatin decrease hemorrhage from injured liver in rats?(2009) Akçora, Bülent; Altug, Enes M.; Fansa, Iyad; Nisanoglu, VedatIn portal hypertensive patients, somatostatin (SMT) and octreotide have been widely used to decrease variceal bleeding because of its splanchnic hypoperfusion effect. The aim of this study was to explore the effects of somatostatin treatment for decreasing blood loss of uncontrolled liver hemorrhage model in rats.Twenty-one male rats were divided into 3 groups including group 1; nontreatment, group 2; isotonic saline infusion and group 3; isotonic saline plus SMT infusion. Intra-abdominal bleeding was induced by transection of median lobe of liver. Mean arterial pressures (MAP), amount of intra-peritoneal blood collection and hematocrit (Hct) changes were evaluated for 60 minutes.There was no difference in the MAP changes between the groups until 25th minute. Thereafter, MAP remained similar in the group 1 while gradually increased (P < 0.05) in the group 2 and 3. There was no statistically significant difference between the groups 2 and 3. End of study, the highest Hct value was determined in the nontreatment group (41.0 ± 3.26 %) and it significantly different from other two groups. We found increase of Htc value in the group 3 (32.3 ± 2.75 %) when compared with group 2 (29.7 ± 4.19 %), but it was not statistically significant. The highest intra-peritoneal blood volume was determined in group 2. We found decrease of the hemorrhage in the group 3 when compared with the group 2, but it was not statistically significant. Somatostatin using has a tendency, although not statistically significant, to decrease of intraperitoneal hemorrhage from liver in the rat model. © 2009 OMU All rights reserved.Öğe Early Outcomes of Radial Artery Use in All-Arterial Grafting of the Coronary Arteries in Patients 65 Years and Older(Texas Heart Inst, 2010) Erdil, Nevzat; Nisanoglu, Vedat; Eroglu, Tamer; Fansa, Iyad; Cihan, Hasan Berat; Battaloglu, BektasWe retrospectively evaluated early clinical results of coronary revascularization using none but arterial grafts in patients aged 65 years and older. The cases of 449 consecutive patients who had undergone isolated myocardial revascularization were divided into 2 groups: the arterial conduit group (n=107) received a left internal mammary artery (LIMA) graft and 1 or both radial arteries (RAs), while the mixed-conduit group (n=342) received a LIMA graft and 1 or more saphenous vein grafts (SVGs), with or without an RA. There was no significant difference between the groups' rates of mortality The arterial conduit group had a significantly shorter overall postoperative hospital stay than did the mixed-conduit group (mean, 6.6 +/- 0.9 vs 7.2 +/- 5 days; P=0.04). Linear regression analysis revealed that the presence of hypertension (beta=0.13; 95% confidence interval [CI], 0.054-0.759; P=0.02) and high EuroSCORE (beta=0.24; 95% CI, 0.053-0.283; P=0.004) were the major predicting factors for long hospital stay Graft-harvest-site infection was statistically more frequent in the mixed-conduit group than in the arterial conduit group (6.4% vs 0, respectively; P=0.007). Angiography was performed postoperatively (mean, 24.9 +/- 16.3 mo; range, 17-65 mo) in 21 patients. In these patients, all LIMA grafts were patent, as were 86.9% of the SVGs and 90.9% of the RA grafts. Myocardial revascularization using all arterial grafts (at least 50% RAs) in patients aged 65 years and older is safe and reliable, produces short-term results equal to those of saphenous vein grafting, and can reduce graft-harvest-site infections. (Tex Heart Inst J 2010; 37(3):301-6)Öğe Early outcomes of radial artery use in all-arterial grafting: Of the coronary arteries in patients 65 years and older(Texas Heart Institute, 2010) Erdil, Nevzat; Nisanoglu, Vedat; Eroglu, Tamer; Fansa, Lyad; Cihan, Hasan Berat; Battaloglu, BektasWe retrospectively evaluated early clinical results of coronary revascularization using none but arterial grafts in patients aged 65 years and older. The cases of 449 consecutive patients who had undergone isolated myocardial revascularization were divided into 2 groups: the arterial conduit group (n=107) received a left internal mammary artery (LIMA) graft and 1 or both radial arteries (RAs), while the mixed-conduit group (n=342) received a LIMA graft and 1 or more saphenous vein grafts (SVGs), with or without an RA. There was no significant difference between the groups' rates of mortality. The arterial conduit group had a significantly shorter overall postoperative hospital stay than did the mixed-conduit group (mean, 6.6 ± 0.9 vs 7.2 ± 5 days; P=0.04). Linear regression analysis revealed that the presence of hypertension (?=0.13; 95% confidence interval [CI], 0.054-0.759; P=0.02) and high EuroSCORE (?=0.24; 95% CI, 0.053-0.283; P=0.004) were the major predicting factors for long hospital stay. Graft-harvest-site infection was statistically more frequent in the mixed-conduit group than in the arterial conduit group (6.4% vs 0, respectively; P=0.007). Angiography was performed postoperatively (mean, 24.9 ± 16.3 mo; range, 11-65 mo) in 21 patients. In these patients, all LIMA grafts were patent, as were 86.9% of the SVGs and 90.9% of the RA grafts. Myocardial revascularization using all arterial grafts (at least 50% RAs) in patients aged 65 years and older is safe and reliable, produces short-term results equal to those of saphenous vein grafting, and can reduce graft-harvest-site infections. © 2010 by the Texas Heart® Institute, Houston.Öğe True popliteal aneurysm presenting with acute limb ischemia and deep venous thrombosis: Report of a case(Int Scientific Literature, Inc, 2008) Erdil, Nevzat; Nisanoglu, Vedat; Eroglu, Tamer; Fansa, Iyad; Cihan, Hasan Berat; Battaloglu, BektasBackground: True popliteal aneurysm complicated with distal arterial embolization and popliteal vein thrombosis is rare. Case Report: We report a case of a 26-year-old male with popliteal artery aneurysm who presented with two major complication related to the aneurysm; distal arterial embolization and popliteal vein thrombosis. He was treated successfully by vein graft interposition and anticoagulation therapy. Conclusions: This case suggests popliteal aneurysm may cause concurrent limb-threatening complications such as acute leg ischemia and deep venous thrombosis.
