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    Determination of 25 hydroxyvitamin D reference ranges in Hatay region by indirect method
    (2023) Oğuzman, Hamdi; Doğan, Serdar
    Objective: The aim of this study is to determine the reference ranges of 25 hydroxyvitamin D (25(OH)D) levels from the serum 25(OH)D results of the patients and to investigate variations across age and gender groups. Methods: The patients (n=26829) who applied to Hatay Mustafa Kemal University Hospital between January 2018 and December 2019 and whose 25(OH)D levels were studied were included in this retrospective study. Serum 25(OH)D levels were studied by the chemiluminescence immunoassay method. The hospital information management system was used to obtain the test results and patient data. The indirect method was used to determine the reference ranges. Results: The prevalence of 25(OH)D deficiency in the patients participating in this study was 60.9% in the general population, 54.9% in men, and 67.5% in women. It has been observed that 25(OH)D deficiency is more common in women than in men. The reference ranges determined in this study were lower than the reference ranges provided by the manufacturer. Conclusion: In this study, 25(OH)D levels and reference ranges of Hatay Region were determined in a very large population. It can be said that the results of our region will contribute to the studies to be carried out on the determination of 25(OH)D levels and reference ranges throughout the country.
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    ORAL PRESENTATION ABSTRACTS
    (De Gruyter Open Ltd, 2024) Özcan, Oğuzhan; Doğan, Serdar; Çiçek, Güner; Kaçmaz, Filiz; Oğuzman, Hamdi; Arpacı, Abdullah
    Objectives: This study investigated the effect of aerobic exercise on serum irisin, preptin levels in overweight women and their relationship with routine biochemical tests. Methods: The study included 25 healthy controls and 25 overweight sedentary women (BMI>25). The exercise training was performed 3 days a week for 12 weeks. Anthropometric measurements were performed and fasting blood samples were collected before and after exercise period. All samples were centrifuged at 1500xg for 10 minutes and the serum was separated. Serum irisine and preptin levels were analyzed by ELISA method. Routine biochemical parameters were assayed by spectrophotometric, hsCRP levels by nephelometric and insulin levels by immunoassay method using auto analyzers. Results: There was a significant decrease in BMI and fat mass in the post-exercise group compared with pre-exercise (p<0.001). Serum irisin levels were significantly lower in pre- and post-exercise group compared to controls (p<0.001), but no significant change was observed after exercise period. Preptin levels were significantly higher in the pre-exercise group (median/IQR, 558.2 /351,2-756,8 pg/ml) compared to the controls (median / IQR, 137.1/85.2-427.9 pg/ ml), and significantly reduced in post-exercise group (medium/IQR, 243.1/179.2-330 pg/ml) compared to pre-exercise group. In the pre-exercise group, a significant negative correlation was observed between irisin and body mass index (r=-0.443, p=0,027), while a positive correlation was found between preptin and body weight (r=0.438, p=0.029). Conclusions: Twelve weeks of aerobic exercise in overweight sedentary women has lowering effect on serum preptin levels but no effect on serum irisin levels. © 2024 De Gruyter Open Ltd. All rights reserved.