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    The effect of caffeic acid phenethyl ester on isoproterenol-induced myocardial injury in hypertensive rats
    (2014) İlhan, Selçuk; Yılmaz, Nigar; Nacar, Emel; Motor, Sedat; Oktar, Süleyman; Şahna, Engin
    Objective: The aim of this study is to investigate the effects of caffeic acid phenethyl ester (CAPE) on isoproterenol (ISO)-induced myocardial injury in hypertensive rats. Methods: Rats were divided into 4 groups (n=29): Control group (n=8), L-NNA (NG-Nitro-L-arginine) group (n=8), L-NNA+ISO (L-NNA+isoproterenol) group (n=7) and L-NNA+ISO+CAPE (L-NNA+ISO + caffeic acid phenethyl ester) group (n=6). ISO (150 mg/kg/day) was given intraperitoneally (i.p.) once a day for 2 consecutive days (at the 12th and 13th days of L-NNA treatment). NG-Nitro-L-arginine (L-NNA) was given orally (25 mg/kg/day) in drinking water for 14 days. CAPE (10 ?mol/kg/day) was given (i.p.) for 7 days after the first week. Systolic blood pressure (SBP) was evaluated by the tail-cuff method and biochemical analysis were performed using an autoanalyzer and a spectrophotometer.Results: SBP in all L-NNA-treated groups was found to be increased at seventh day. AST and LDH levels in LNNA+ISO group were significantly increased compared to control (AST: 125±5 vs. 105±2; LDH: 861±154 vs. 571±46 U/L respectively) (p<0.05). Also, ISO caused to extensive necrosis and mononuclear cell infiltration in hypertensive rat myocardium. CAPE application reversed the enhanced AST and LDH levels as well as the extensive necrosis and the mononuclear cell infiltration in LNNA+ISO+CAPE group compared LNNA+ISO.Conclusion: According to our findings, it might be suggested that CAPE may be a favorable agent to protect the hypertensive myocardium from the injury induced by isoproterenol via mechanisms such as the induction of the antioxidant enzymes and the inhibition of lipid peroxidation.
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    Effects of caffeic acid phenethyl ester on isoproterenol-induced myocardial infarction in rats
    (2010) Oktar, Süleyman; Aydın, Mehmet; Yönden, Zafer; Alçin, Ergül; İlhan, Selçuk; Nacar, Ahmet
    Caffeic acid phenethyl ester (CAPE) is a natural product with potent anti-inflammatory, antitumor and antioxidant activities and attenuates inflammation and lipid peroxidation induced by ischemia-reperfusion injury. The purpose of the present study was to investigate the effects of CAPE on isoproterenol (ISO) -induced myocardial infarction. Methods: A randomized controlled experimental design was used in this study. Rats were divided into four groups and treated with saline, CAPE, ISO and ISO+CAPE. Rats were treated with CAPE (10 &#956;mol kg/day i.p.) or saline starting 3 days before injecting ISO (150 mg /kg s.c., 24 hours). Seven days later, rats were sacrificed and the hearts were excised for biochemical analyses and microscopic examination. One-way ANOVA test with post hoc multiple comparisons using LSD method were used for statistical analysis of the data. Results: The administration of ISO alone resulted in higher myeloperoxidase (MPO) activity, lipid peroxidation, superoxide dismutase (SOD) and catalase (CAT) than in the control. The enzyme activities did not change in rat given CAPE alone. CAPE treatment prevented the increase in MPO activity and malondialdehyde, but did not affect the activities SOD and CAT enzymes. Conclusion: In light of these results, we conclude that CAPE prevents MPO-and lipid peroxidation-mediated myocardial injury via inhibition of neutrophil&#8217;s MPO activity.
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    Increased plasma nesfatin -1 levels in patients with obsessive compulsive disorder
    (2012) Bez, Yasin; Arı, Mustafa; Öztürk, Oktay Hasan; Oktar, Süleyman; Can, Yeşim
    Objective: To determine and compare the plasma nesfatin-1 (a satiety peptide) levels of patients with obsessive compulsive disorder (OCD) and healthy control subjects. Method: Plasma nesfatin-1 levels of 31 patients with OCD (18 females, 13 males) and 28 healthy control subjects (16 females and 12 males) similar to the study group in terms of weight, age, and gender were measured in this study. Severity of obsessions and compulsions both in OCD patients and control subjects were determined by using Yale-Brown Obsessive Compulsive Scale (Y-BOCS). ELISA method was used to measure plasma nesfatin-1 levels. Results: Median plasma nesfatin-1 levels in patients with OCD and healthy control subjects were 4.61 ng/ml (min-max: 1.28-8.11) and 2.0 ng/ml (min-max: 0.11-4.98) respectively. The observed difference in plasma nesfatin-1 levels between two groups was statistically significant (p<0.001). No statistically significant correlation was observed between Y-BOCS scores and plasma nesfatin-1 levels either in the study group (r=0.205, p=0.27) or in the control group (r=0.335, p=0.071). Conclusion: Increased plasma nesfatin-1 levels observed in patients with OCD suggest a potential role to nesfatin-1 in anxiety states besides its previosly known anorexigenic effects.
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    Plasma nesfatin-1 level may be associated with disease severity in patients with panic disorder
    (2010) Bez, Yasin; Arı, Mustafa; Öztürk, Oktay Hasan; Oktar, Süleyman; Can, Yeşim; Söğüt, Sadık
    Objective: We have compared the plasma levels of the recently discovered peptide hormone nesfatin-1 between patients with panic disorder (PD) and healthy control subjects. Method: The subjects in the patient group were selected from the patients who presented to the psychiatry outpatient clinic of a university hospital and were diagnosed with PD. Healthy subjects similar to the patient group in terms of age, gender, weight, and BMI constituted the control group in this study. The Panic-Agoraphobia Scale (PAS) was applied to all subjects in both groups. Blood samples were collected to measure plasma nesfatin-1 level by using ELISA method. Results: Mean plasma nesfatin-1 level (4.66 ± 2.39 ng/ml in patient group, 2.13 ± 1.52 ng/ml in control group) was higher in patients with PD than in the control group (p<0.001). A positive correlation between PAS scores and plasma nesfatin-1 levels was found in the patients with PD. Conclusion: There may be a relationship between disease severity and plasma nesfatin-1 levels in panic disorder patients. Future studies investigating this relationship are needed.