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Öğe Ala-9Val polymorphism of Mn-SOD gene in sickle cell anemia(Funpec-Editora, 2011) Sogut, S.; Yonden, Z.; Kaya, H.; Oktar, S.; Tutanc, M.; Yilmaz, H. R.; Yigit, A.Oxidative stress may be contributory to the pathophysiology of the abnormalities that underlie the clinical course of sickle cell anemia. We looked for a possible genetic association between the functional polymorphism Ala-9Val in the human Mn-SOD gene and sickle cell anemia. One hundred and twenty-seven patients with sickle cell anemia and 127 healthy controls were recruited into the study. Alanine versus valine polymorphism in the signal peptide of the Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with the restriction enzyme NgoMIV. In the sickle cell anemia patients, the frequency of Val/Val genotype was approximately 1.4-fold lower and that of Ala/Val was 1.3-fold higher compared to the controls. No significant difference in genotype frequencies was found between patients and controls (chi(2) = 4.561, d.f. = 2, P = 0.101). The Val-9 was the most common allele in patient and healthy subjects. No significant difference in allele frequencies was found between patients and controls (chi(2) = 1.496, d.f. = 1, P = 0.221). We conclude that the Mn-SOD gene polymorphism is not associated with sickle cell anemia.Öğe BENEFICIAL EFFECT OF ERDOSTEINE ON METHOTREXATE-INDUCED TESTICULAR TOXICITY IN MICE(Elsevier Science Bv, 2010) Oktar, S.; Gokce, A.; Aydin, M.; Davarci, M.; Meydan, S.; Ozturk, O. H.; Koc, A.[Abstract Not Available]Öğe Direct and indirect effects of kisspeptin on liver oxidant and antioxidant systems in young male rats(Wiley, 2010) Aydin, M.; Oktar, S.; Yonden, Z.; Ozturk, O. H.; Yilmaz, B.Kisspeptin is a recently discovered hypothalamic peptide which plays an important role in the central control of reproductive functions We have investigated direct and indirect effects of kisspeptin on the liver oxidative stress in young male rats Twenty-four rats were divided into four groups (n = 6/group) First group served as control and received saline. Kisspeptin-10 was administered to the animals in the second group (20 nmol/rat/day), for a period of 7 days Rats were given only one dose gosereline (0 9 mg/rat), a GnRH agonist in the third group The last group received kisspeptin-10 with gosereline. The activities of catalase, superoxide dismutase (SOD), xanthine oxidase (XO), adenosine deaminase (AD) and level of malondialdehyde were studied in liver tissue Serum samples were separated for total antioxidant capacity (TAC), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, blood urea nitrogen (BUN), colesterol, lipoprotein (HDL) and triglyceride. Kisspeptin increased the activities of SOD and catalase (p < 0 05) When compared to the control group. the levels of malondialdehyde. TOS and AST were lower, but levels of BUN, cholesterole, HDL and AD were higher in the other three groups (p < 0.05) In conclusion, our findings suggest that kisspeptin may have antioxidant and thus protective effects on the liver tissue Copyright (C) 2010 John Wiley & Sons, LtdÖğe Investigation of Bisphenol A as an endocrine disruptor, total thiol, malondialdehyde, and C-reactive protein levels in chronic obstructive pulmonary disease(Verduci Publisher, 2014) Erden, E. S.; Motor, S.; Ustun, I.; Demirkose, M.; Yuksel, R.; Okur, R.; Oktar, S.OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is a common health problem and it is associated with oxidant/antioxidant imbalance and systemic inflammation. Bisphenol A (BPA) is an endocrine disruptor agent, exerting a wide variety of metabolic effects. Also, BPA is related with oxidative stress, decreased antioxidant enzymes, and inflammation. The aim of this study is to investigate the relationships between COPD and serum BPA, Creactive protein (CRP), malondialdehyde (MDA), and total thiol levels. PATIENTS AND METHODS: This study was enrolled at 83 subjects that they were divided into two groups: control (n = 33), COPD (n = 50). The serum BPA, CRP, MDA, and total thiol levels were analyzed. RESULTS: The CRP and BPA levels were significantly higher in the COPD patients than control subjects. The total thiol levels were significantly lower in COPD cases than the controls. There is no different between groups for MDA. Also, there had a linear relationship between BPA and CRP in correlation analysis. CONCLUSIONS: COPD is associated with high serum BPA, CRP and low total thiol levels in comparison with healthy individuals. It is suggested that BPA might have a role in the etiopathogenesis of COPD.Öğe Protective effect of caffeic acid phenethyl ester on cyclosporine A-induced nephrotoxicity in rats(Elsevier Science Bv, 2009) Gokce, A.; Oktar, S.; Aydin, M.; Ilhan, S.; Yonden, Z.; Ozkan, O. V.; Davarci, M.[Abstract Not Available]Öğe PROTECTIVE EFFECT OF THYMOQUINONE IN EXPERIMENTAL TESTICULAR TORSION(Elsevier Science Bv, 2010) Gokce, A.; Oktar, S.; Koc, A.; Gonenci, R.; Yalcinkaya, F.; Yonden, Z.; Duru, M.[Abstract Not Available]Öğe Protective effects of caffeic acid phenethyl ester on iron-induced liver damage in rats(Springer, 2009) Oktar, S.; Yonden, Z.; Aydin, M.; Ilhan, S.; Alcin, E.; Ozturk, O. H.S. OKTAR, Z. YONDEN, M. AYDIN, S. ILHAN, E. ALCIN and O.H. OZTURK. Protective effects of caffeic acid phenethyl ester on iron-induced liver damage in rats. J Physiol Biochem, 65 (4), 339-344, 2009. Caffeic acid phenethyl ester (CAPE) is a natural product with potent anti-inflammatory, antitumor, and antioxidant activities, and attenuates inflammation and lipid peroxidation. The purpose of the present study was to investigate the effects of CAPE on iron-induced liver damage. Rats were divided into four groups and treated for 7 days with saline (control group), 10 mu mol kg CAPE/day s.c. (CAPE group), 50 mg iron-dextran/kg i.p. (IRON group) and CAPE and iron at the same time (IRON+CAPE group). Seven days later, rats were killed and the livers were excised for biochemical analysis. The administration of IRON alone resulted in higher myeloperoxidase (MPO) activity and lipid peroxidation than in the control and CAPE treatment prevented the increase in MPO activity and malondialdeyde (MDA) level. No differences were observed in all four groups with regards to superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities. Our results collectively suggest that CAPE may be an available agent to protect the liver from injury via inhibition of MPO activity.
