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Öğe ASSESSMENT OF HEADACHE IN MEN TAKING PHOSPHODIESTERASE-5 INHIBITOR (TADALAFIL) FOR ERECTILE DYSFUNCTION(Carbone Editore, 2014) Okuyucu, E. Esra; Guven, Oguz; Ucar, Edip; Duman, TaskinAims: Tadalafil, a selective inhibitor of the cyclic guanosine monophosphate (cGMP) degrading phosphodiesterase 5 (PDE5), is known to cause headache as a secondary effect. This study was undertaken to assess the frequency, clinical characteristics of headache prospectively in a group of erectile dysfunction patients taking tadalafil as a PDE inhibitor. Materials and methods: As the first step of study, the question about having ever headache in last year was asked. Of the 31 patients, 16 patients (51.6%) had yes as an answer for the presence of headache. A questionnaire was given to the patients who had experienced headache whether recurrent or not. When patients were at headache-free period, tadalafil (20 mg) was administrated to each patient. The question about having headache was asked 5 hours and 48 hours later. According to the answer of this question, second questionnaire was conducted. The analysis of questionnaires was made separately. International Classification of Headache Disorders (ICHD) has been used for the case definition criteria. Results: A statistical significant difference was observed for the occurrence of headache between the baseline, 5th and 48th hours (p=0.001, cochrans Q test). However, we found no significant difference in headache occurrence between fifth hour and 48th hour of tadalafil 20 mg administration (p=0.687, Mc Nemar test). Conclusion: So from this study, it can be concluded that tadalafil can trigger headache attacks within the half-life of the drug.Öğe A case of neurobrucellosis(Turkish Society of Cerebrovascular Diseases, 2011) Okuyucu, E. Esra; Yilmazer, Serkan; Dede, Hava Özlem; Melek, Ismet; Duman, TaşkinCausing serious morbidities and having so many different clinic formes are the clinical importances of brucellosis, which is a zoonotic infections. Neurobrucellosis, can appear with cranial nerve pathologies, optic stasis, menengitis, myelitis, radiculopathy, periferic neuropathy etc. The case is the woman who is 69 years old. Her complaints began as lumbar pain 3 years ago. She has not been able to stand unaided for a year. In the periventricular white matter chronic ischemic lessions, and in the right serebellar hemisfer an encephalomalasia were determined in the kranial MRI. Brucella tube agglitunation was 1/160(+). Clinic remission observed after neurobrucellosis treatment. The neurobrucellosis is a manifestation that can appear in a lot of different clinic formes; and it requires attention in the differential diagnoastics of several diseases.Öğe Does transcutaneous nerve stimulation have effect on sympathetic skin response?(Elsevier Sci Ltd, 2018) Okuyucu, E. Esra; Turhanoglu, Ayse Dicle; Guntel, Murat; Yilmazer, Serkan; Savas, Nazan; Mansuroglu, AyhanObjective: This study examined the effects of transcutaneous electrical nerve stimulation (TENS) on the sympathetic nerve system by sympathetic skin response test. Methods: Fifty-five healthy volunteers received either: (i) 30 minutes TENS (25 participants) (ii) 30 minutes sham TENS (30 participants) and SSR test was performed pre- and post-TENS. The mean values of latency and peak-to-peak amplitude of five consecutive SSRs were calculated. Results: A significant amplitude difference was found between TENS and sham TENS group both in right and left hand (p = 0.04, p = 0.01, respectively). However there was no significant latancy difference between two groups (p>0.05). Conclusion: TENS has an inhibitory effect on elicited SNS responses when compared with sham TENS control group. (C) 2017 Elsevier Ltd. All rights reserved.Öğe Neuralgiform pain in a patient with sickle cell anemia and stroke(Turkish Society of Cerebrovascular Diseases, 2010) Okuyucu, E. Esra; Dede, Hava Özlem; Melek, Ismet; Duman, TaşkinSickle cell disease (SCD) is characterized by intermittent vaso-occlusive events and chronic hemolytic anemia. This genetic disease has mortal complications. Vaso-occlusive events result in tissue ischemia leading to acute and chronic pain as well as organ damage. People who hasn't have any organ damage, can live to fifth decade ,and 22% of these people die because of stroke. The woman is a carrier of sickle cell disease with complaints of neuralgia headache. No pathological symptom was encountered during the neuralogical exam. However subacute infarct on right corpus striatum and chronic infarct on the periventricular white matter were determined in the cranial MRI. Magnetic resonance venography of the brain indicated left sigmoid sinus thrombosis. The case is important because of having different cerebrovascular accident formes which were produced by sickle cell anemia.Öğe PREVALANCE AND CLINICAL FINDINGS OF PRIMARY HEADACHES IN PEOPLE WITH MULTIPLE SCLEROSIS(Nobel Ilac, 2009) Okuyucu, E. Esra; Balci, Ali; Beyaz, OezguerObjective: The aim of the study was to investigate the prevalance of primary headache and clinical evaluation Of primary headaches according to the International Headache Society criteria in patients with multiple sclerosis. The relationship between primary headache and multiple sclerosis subtypes, locations of plaques on magnetic resonance of these patients were also investigated. Material and Method: A total of 3.1 patients with clinically definite MS according to the McDonald's criteria, 22 females and 9 men, were included in the study. The Study conducted in two phases; face-to-face interview phase and evaluation of magnetic resonance imaging phase. Results: The prevalance of all headaches was 71.0% in 31 patients. Migraine without aura was found in 22.6%, migraine with aura in 19.4% and tension type headache in 29%. Primary headaches were found to be most common in relapsing-remitting MS. Lesions of red nucleus (RNT), substantia migra (SN), periaquaductal gray matter (PGM), dorsolateral pontine nucleus (DPN) were found in all patients, with frequency from 22.6% to 48.4%. While all patients with migraine had supratentoriel lesion, neither of the patients had infratentoriel lesion alone. Conclusion: The findings suggest that primary headaches are common in patients with multiple sclerosis. Demyelinating lesions in RN, SN, PGM, DPN might be responsible from the presence of primary headaches in patients with MS. But for understanding the mechanisms underlying this association, further studies are needed.
