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Öğe Analysis of the effects of subthalamic nucleus deep brain stimulation on somatosensation in Parkinson's disease patients(Springer-Verlag Italia Srl, 2020) Huzmeli, Esra Dogru; Yilmaz, Atilla; Okuyucu, EsraObjective Despite the subthalamic nucleus (STN) deep brain stimulation (DBS) is a treatment commonly used to ameliorate the motor symptoms of Parkinson's disease (PD), its effects on somatosensation is unclear. The purpose of this study was to investigate the potential effects of DBS on temperature, proprioceptive, tactile, exteroceptive, pain and cortical sensations, and odor identification in PD patients. Methods The study included 14 patients (with a mean age of 59.78 +/- 11.03 years; range, 44-70 years) with idiopathic PD who underwent DBS surgery for movement disorders caused by PD at the same Neurosurgery Department. All patients were tested while DBS was turned on (DBS-ON) and off (DBS-OFF). To clearly observe the effect of removing stimulation off, DBS devices were turned off by experimental clinical personnel for a minimum duration of 30 min prior to examination. Temperature, proprioceptive, tactile, exteroceptive, pain and cortical sensations, and odor identification were examined. Results We found that two-point discrimination was significantly lower during DBS-ON than DBS-OFF (p = 0.031). Tactile sensation and kinesthesia deviation degree were lower during DBS-ON than DBS-OFF, but were non-significant (p > 0.05). The number of correct answers on an assessment of graphesthesia was higher during DBS-ON, but was non-significant as well (p > 0.05). Odor identification was better during DBS-OFF. Conclusions DBS may have an effective role to improve somatosensation and DBS-related benefits may not be explained by improvements in motor function alone, but rather by enhanced somatosensory processing. Further studies with larger study groups are needed.Öğe Atypical Herpes Simplex Encephalitis With Extratemporal Involvement(Lippincott Williams & Wilkins, 2007) Okuyucu, Esra; Melek, Ismet; Duman, Taskin; Balci, Ali; Eraslan, TuraliHerpes simplex virus (HSV) is recognized as the most common cause of sporadic encephalitis among adults. The combination of magnetic resonance imaging, electroencephalography, and cerebrospinal fluid tests is usually diagnostic. In this article, we describe a case of atypical HSV encephalitis presenting a syndrome of febrile encephalopathy in the absence of focal neurological features, including mental and sensory disturbance, pyramidal signs, ataxia, and cranial nerve deficits, and in which magnetic resonance imaging demonstrated lesions restricted to the parietal and occipital lobes without typical localization of HSV encephalitis in the insula and inferior frontal lobe.Öğe BPPV tedavisinde epley manevrasının etkinliği ve uygulamada ortaya çıkan nistagmus yönünün tedavi başarısı için erken bir gösterge olarak rolü(2007) Akoğlu, Ertap; Okuyucu, Şemsettin; Okuyucu, Esra; Melek, Murat İsmet; Duman, Taşkın; Dağlı, Ali ŞafakAmaç: Benign paroksismal pozisyonel vertigoda (BPPV) Epley manevrası sırasında oluşabilen nistagmusun yönünün tedavi başarısını erken belirlemedeki rolü araştırıldı. Hastalar ve Yöntemler: Bu çalışmada BPPV nedeniyle 47 hastaya (24 erkek, 23 kadın; ort. yaş 46±12; dağılım 29-70) Epley manevrası uygulandı ve olgularda nistagmus oluşup oluşmadığı, varsa yönü gözlendi. Bulgular: Epley manevrası sırasında dokuzunda aynı, yedisinde karşı yönde olmak üzere 16 hastada nistagmus gözlendi. Aynı yönde nistagmus gözlenen yedi hastada (%77.8) tedavi başarılı oldu. Manevra sırasında karşı yönde nistagmus saptanan yedi hastanın hiçbirinde başarı elde edilemedi. Aynı tarafa nistagmus ile tedavi başarısı arasında anlamlı ilişki saptanmaz iken (p=0.625), karşı tarafa nistagmus varlığı ile tedavi başarısızlığı arasındaki ilişki anlamlıydı (p=0.000). Sonuç: Epley manevrası sırasında oluşan nistagmus karşı yönde ise manevranın başarısız olacağı öngörülebilir.Öğe Diabetic Radiculoplexus Neuropathy Involving the Upper Extremity: A Case Report(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2010) Turhanoglu, Ayse Dicle; Guler, Hayal; Okuyucu, Esra; Kizil, NurhanDiabetic radiculoplexus neuropathy is a relatively rare condition, in which unilateral or bilateral muscular weakness that acutely or subacutely develops mainly around the hip in type 2 diabetes patients. A 71-year-old man with diabetes mellitus presented with asymmetrical weakness and atrophy of the right shoulder girdle muscles for the last 3 months. He had limitation of right shoulder range of motions and could not raise his right arm. Our patient, who fulfilled the criteria for the diagnosis of diabetic radiculoplexus neuropathy based on clinical and electrodiagnostic features, is reported and discussed in the light of the literature. Turk J Phys Med Rehab 2010;56:148-51.Öğe Effect of tamsulosin therapy on lower urinary tract symptoms in Parkinson's disease(2008) Görür, Sadik; Melek, Ismet Murat; Okuyucu, Esra; Helli, Ali; Duman, Taşkin; Kiper, Ahmet NamikIntroduction: The aim of this study is to evaluate the intensity of lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH) with and without Parkinson's disease (PD). We also investigated the efficacy of tamsulosin therapy in the management of the subjective and objective symptoms in these patients. Materials and Methods: This study included 80 (40 patients with and 40 without PD) clinically diagnosed BPH patients treated with tamsulosin. International Prostate Symptom score (IPSS), quality of life (QoL), maximum flow rate (Qmax) and post-void residual urine volume (PVR) were determined at baseline and after the 3 months of therapy. The PD group also evaluated with Unified Parkinson's Disease Rating Scale (UPDRS). All patients had received tamsulosin 0.4 mg/per day for 3 months period. The relationship between PD duration and UPDRS and mean changes of IPSS, QoL, Qmax and PVR after tamsulosin therapy were also investigated in PD group. Results: Three patients (7.5%) in PD group were discontinuied the therapy due to the severe hypotension attack. Initial data of IPSS, QoL, Qmax and PVR were different between two groups (p<0.001). After tamsulosin treatment, LUTS improved significantly in both groups (p<0.05). Improvement rates of the IPSS, QoL, Qmax and PVR were significantly higher in non-PD group (p<0.05). When relationship were investigated between PD duration and UPDRS and mean changes of IPSS, QoL, Qmax and PVR after tamsulosin therapy, all parameters were found in correlation except PVR. Conclusion: Tamsulosin therapy appears to useful in PD patient with BPH. But its efficacy is changed with PD duration and severity. After all, tamsulosin therapy can be given to these patients group with close follow-up.Öğe EFFECT OF TAMSULOSIN THERAPY ON LOWER URINARY TRACT SYMPTOMS IN PARKINSON'S DISEASE(Aves, 2008) Gorur, Sadik; Melek, Ismet Murat; Okuyucu, Esra; Helli, Ali; Duman, Taskin; Kiper, Ahmet NamikIntroduction: The aim of this study is to evaluate the intensity of lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH) with and without Parkinson's disease (PD). We also investigated the efficacy of tamsulosin therapy in the management of the subjective and objective symptoms in these patients. Materials and Methods: This study included 80 (40 patients with and 40 without PD) clinically diagnosed BPH patients treated with tamsulosin. International Prostate Symptom score (IPSS), quality of life (QoL), maximum flow rate (Qmax) and post-void residual urine volume (PVR) were determined at baseline and after the 3 months of therapy. The PD group also evaluated with Unified Parkinson's Disease Rating Scale (UPDRS). All patients had received tamsulosin 0.4 mg/per day for 3 months period. The relationship between PD duration and UPDRS and mean changes of IPSS, QoL, Qmax and PVR after tamsulosin therapy were also investigated in PD group. Results: Three patients (7.5%) in PD group were discontinuied the therapy due to the severe hypotension attack. Initial data of IPSS, QoL, Qmax and PVR were different between two groups (p<0.001). After tamsulosin treatment, LUTS improved significantly in both groups (p<0.05). Improvement rates of the IPSS, QoL, Qmax and PVR were significantly higher in non-PD group (p<0.05). When relationship were investigated between PD duration and UPDRS and mean changes of IPSS, QoL, Qmax and PVR after tamsulosin therapy, all parameters were found in correlation except PVR. Conclusion: Tamsulosin therapy appears to useful in PD patient with BPH. But its efficacy is changed with PD duration and severity. After all, tamsulosin therapy can be given to these patients group with close follow-up.Öğe The effectiveness of the Epley maneuver for the treatment of BPPV and the role of nystagmus direction as an early indicator of successful treatment(2007) Ako?lu, Ertap; Okuyucu, Semsettin; Okuyucu, Esra; Melek, Ismet Murat; Duman, Taşkin; Da?li, Ali SafakOBJECTIVES: We investigated the role of the direction of nystagmus that might occur during the Epley maneuver as an early indicator for treatment success in benign paroxysmal positional vertigo (BPPV). PATIENTS AND METHODS: The study included 47 patients (24 males, 23 females; mean age 46+/-12 years; range 29 to 70 years) who underwent the Epley maneuver for BPPV. The occurrence and the direction of nystagmus were observed. RESULTS: Nystagmus occurred in 16 patients during the maneuver, being ipsilateral in nine patients and contralateral in seven patients. The treatment was successful in seven patients (77.8%) with ipsilateral nystagmus, whereas none of the patients with contralateral nystagmus benefited from the maneuver. While there was no significant relationship between ipsilateral nystagmus and the success of the treatment (p=0.625), a significant correlation was found between contralateral nystagmus and treatment failure (p=0.000). CONCLUSION: The occurrence of contralateral nystagmus during the Epley maneuver may be a sign of an unsuccessful result.Öğe Effects of a rehabilitation program for Parkinson's patients on reaction and movement time: an electromyographic study(Cukurova Univ, Fac Medicine, 2022) Kizil, Nurhan; Ogut, Halil; Okuyucu, Esra; Guler, Hayal; Ozer, Cahit; Turhanoglu, Ayse DiclePurpose: The aim of the study was to investigate the effects of a rehabilitation program consisting of specific exercises for Parkinson's Disease (PD) patients on reaction time (RT), movement time (MT), quality of life and disease activity. Materials and Methods: A total of 26 idiopathic PD patients were included in the study. The exercises specific to Parkinson's were applied to the patients for 16 weeks. The evaluation of the patients were done before and after the treatment. The disease severity was measured with Unified Parkinson's Disease Rating Scale (UPDRS), quality of life was measured with Short Form-36 (SF-36). RT and MT measurements were done electromyographically. Results: There was no statistically significant difference in UPDRS total and sub-section values and SF-36 quality of life evaluation before and after the exercise program. While a significant decrease was observed in the RT values of the patients after the 16 week exercise program compared to prior to the program (Deltoid RT 370.46 +/- 25 to 219.58 +/- 17, biceps RT 370.42 +/- 27 to 216.49 +/- 14 and triceps RT 445.21 +/- 31 to 247.53 +/- 23, respectively). Conclusion: In PD, the rehabilitation program specific to the disease leads to a significant decrease in RT. Although the exercise has no statistically significant effect on disease activity, quality of life and MT values, it was seen that it still led to improvement.Öğe The frequency of slime, adhesin and methicillin resistance genes among staphylococci isolated from nasal samples of multiple sclerosis patients(Academic Journals, 2011) Melek, Ismet M.; Duran, Nizami; Duran, Gulay G.; Duman, Taskin; Okuyucu, EsraIt was aimed to determine the carriage rate of Staphylococcus aureus and the occurrence of methicillin resistance, slime and adhesin genes in staphylococcal strains isolated from the nasal cavities of multiple sclerosis (MS) patients. The presence of mecA and femA, and the genes implicated in adhesion were determined by multiplex PCR in all strains. The femA gene was detected in 46.6% of 105 MS patients. While 18.1% of isolates carried the mecA gene, 81.9% of isolates were negative for the mecA gene. The presence of icaA/icaD genes was determined in a total of 84.8% of all strains. While 85.7% of Staphylococcus epidermidis isolates were positive in terms of slime genes, this ratio was determined as 81.6% among the Staphylococcus aureus strains. The occurrence of clfA gene was determined in 29 of 49 (59.2%) S. aureus isolates. Also, 45 out of 49 (91.8%) S. aureus was found to carry the fnbA gene. The carriage rate of the cna gene was determined in 40 (81.6%) isolates among the 49 S. aureus strains. The rate of methicillin resistance gene, slime production and the frequency of adhesin genes in MS patients were also significantly higher than the healthy control population. Determination of the nasal S. aureus carriers and the virulence of these strains will be important for prediction of the MS prognosis in these patients. And treating these S. aureus carriers will be very useful in preventing MS relapses.Öğe Generalized anhidrosis(Riyadh Armed Forces Hospital, 2013) Yilmazer, Serkan; Okuyucu, Esra; Melek, Ismet; Duman, Taskin[Abstract Not Available]Öğe Küme baş ağrısı(2006) Melek, İsmet Murat; Okuyucu, Esra; Duman, TaşkınKüme baş ağrısı birkaç hafta boyunca; her gün ya da günde birkaç kez, ciddi, tek taraflı ve kısmen kısa süreli yineleyen ağrıdır. Küme baş ağrısı tipik olarak 25 yaş dolayında başlar, bazen 45 yaşlarında, geç ortaya çıkabilir. Tipik bir baş ağrısı kümesi 4-8 hafta sürer, bu sırada günde 1-2 kez şiddetlenir. Ağrı, aura olmaksızın aniden, bir gözün çevresinde ya da arkasında başlar. Uluslararası Baş Ağrısı Topluluğu'na göre (IHS) küme baş ağrısının ölçütleri; tek taraflı, orbital, suborbital ve/ya da temporal yerleşimli, tedavi edilmediğinde 15-180 dakika süren, göz kızarması, yaşarması, göz kapağı düşüklüğü, göz bebeği daralması, göz kapağında ödem, burun tıkanıklığı ve akıntısı, yüzde, alında terleme belirtilerinden en az biri görülen, en az beş atağa yol açan şiddetli baş ağ-rısıdır. Küme baş ağrısının farmakolojik tedavisi; akut, profilaktik ya da kombine olabilir.Öğe Manyetik rezonans görüntülemede rastlantısal paranazal sinüs patolojilerinin sıklığı ve hasta semptomları ile ilişkisi(2007) Balcı, Ali; Akoğlu, Ertap; Karazincir, Sinem; Okuyucu, Şemsettin; Karazincir, Olgun; Okuyucu, Esra; Altıntaş, YaseminAmaç: Nörolojik ya da orbital hastalık ön tanıları ile beyin, hipofiz veya orbita MR'ı çekilen bir hasta populasyonunda prospektif olarak paranazal sinüs anomalliği sıklığını araştırdık. Yöntem ve Gereçler: Hastalar paranazal sinus anormallikleri ile ilişkili semptomlar varlığı açısından sorgulandı. Toplam 107 hastaya ait T2 ağırlıklı aksiyal MR kesitlerinde paranazal sinüs patolojisi varlığı araştırıldı. Bu sonuçların hasta semptomları ile korelasyonu araştırıldı. Bulgular: En sık anormallik sırasıyla ön etmoid (% 12.1), arka etmoid (% 10.3), frontal (% 4.7), maksiller (% 4.7) ve sphenoid sinus (% 3.7) şeklinde saptandı. Klinik verilerin istatistiksel analizinde paranazal sinus semptom varlığı ile MR'da saptanan anormallik varlığı arasında ilişki saptanmadı. Sonuç: Bu çalışmadan elde edilen bulgular ışığında, MR'da saptanan rastlantısal paranazal sinus patolojileri ile klinik semptomlar arasında ilişki yok denilebilir.Öğe Multiple Sclerosis and Migraine; Coincidence or Co Morbidity?(Sage Publications Ltd, 2017) Duman, Taskin; Uluduz, Derya; Guntel, Murat; Demetgul, Ozcan; Melek, Ismet; Okuyucu, Esra[Abstract Not Available]Öğe Pain, Sleep Quality and Emotional State of the Relationship between Disease Clinical Features in Patients with Multiple Sclerosis(Sage Publications Ltd, 2015) Dede, Hava Ozlem; Duman, Taskin; Ozer, Cahit; Melek, Ismet; Okuyucu, Esra[Abstract Not Available]Öğe Parkinson hastalarında tamsulosin tedavisinin alt üriner sistem belirtileri üzerine etkisi(2008) Görür, Sadık; Melek, İsmet Murat; Okuyucu, Esra; Helli, Ali; Duman, Taşkın; Kiper, Ahmet NamıkBu çalışmada Benin Prostat Hiperplazisi (BPH) olan Parkinson Hastalarındaki (PH) alt üriner sistem belirtilerinin (AÜSB) şiddetini değerlendirmeyi ve bu olgularda tamsulosin tedavisinin objektif ve subjektif ölçütler üzerine olan etkisini araştırmayı amaçladık. Bu çalışmaya BPH ile birlikte PH olan 40 ve sadece BPH’sı olan 40 olmak üzere toplam 80 olgu alındı. Tüm olgular tedavi öncesi uluslar arası prostat semptom skoru (IPSS), yaşam kalitesi skoru (YK), maksimal idrar akım hızı (Qmax) ve ultrasonografi ile postvoid rezidü (PVR) tayini ile değerlendirildi. PH olan olgular ayrıca Birleşik Parkinson Hastalığı Değerlendirme Ölçeği (BPHDÖ) ile değerlendirildi. Olgulara tamsulosin 0.4 mg/gün tedavi başladı. Tedavi başladıktan 3 ay sonra hastalar objektif ve subjektif parametrelerle tekrar değerlendirilerek tamsulosin tedavisinin etkinliği değerlendirildi. PH grubundan üç olgu (%7.5) şiddetli hipotansif ataklardan dolayı çalışma dışı bırakıldı. Her iki gruptaki olguların demografik verileri arasında fark saptanmazken PH olgularının tedavi öncesi IPSS, YK ve Qmax değerleri kontrol grubuna göre daha düşük ve PVR değerleri ise daha yüksek bulundu (p<0.05). Her iki gruptaki olgular tamsulosin tedavisine iyi yanıt verirken, bu yanıt PH grubunda daha düşük oranda bulundu. PH süresi, BPHDÖ skorları ile subjektif ve objektif parametreler arasındaki ilişki incelendiğinde ise, PVR dışındaki tüm parametrelerin korele olduğu gözlendi. AÜSB olan PH’da tamsulosin tedavisi üriner belirtileri gidermede etkilidir. Fakat bu etki PH süresi ve şiddeti ile ters orantılı olarak azalmaktadır. Buna karşın AÜSB olan PH olgularında tamsulosin tedavisi belirtileri gidermede tedavi boyunca olguların yakın takip edilmesi koşuluyla verilebilir.Öğe Parkinson hastalığında obsesif kompulsif bozukluk(2008) Tunç, Tuğba; Coşkun, Özlem; Özer, Gökhan; Emre, Ufuk; Okuyucu, Esra; Yandı Vargel, Serpil; İnan, Levent ErtuğrulAmaç: İdiopatik Parkinson hastalığı nedeni ile takip edilen hastalarda Leyton Obsesyon Envanteri (LOI) ölçeği ile obsesif kompulsif bozukluğu değerlendirmek. Gereç ve Yöntem: Kliniğimize başvuran ve “United Kingdom Parkinson's Disease Society Brain Bank (UK-PDSBB)” kriterlerine göre Parkinson tanısı konan 50 hasta ve aynı yaş ve cins grubudundan 37 sağılıklı hasta çalışmaya dahil edildi.Hasta ve sağılıklı grup aynı psikiyatrist tarafından değerlendirildi hastalara ve kontrol grubuna Leyton Obsesyon Envanteri (LOI) verildi. Bulgular: Sonuç olarak hastaların obsesyon skorları kontrol grubundan anlamlı olarak daha fazla bulundu(p<0,001). Buna ek olarak hastalık ağırlığı ile obsesyon derecesi arasında anlamlı bir korelasyon saptandı(p:0,771). Sonuç: Parkinson hastalığı öncelikle motor yakınmaların belirgin olduğu ancak zamanla nonmotor belirtilerin de eklendiği bir nörodejeneratif hastalıktır. Hastaların yaşam kalitesi nonmotor bulgular ile birlikte daha kötüleşmektedir. Psikiyatrik bulgular da bu nonmotor yakınmalardan biridir. Bu psikiyatrik bulguların saptanıp tedavi edilmesi hastanın yaşam kalitesini artırabilmektedir.Öğe The prevalence of silent cerebral infarct in patients with sickle cell disease(Turkish Society of Cerebrovascular Diseases, 2008) Balcı, Ali; Okuyucu, Esra; Duman, Taşkin; Gali, Edip; Karazincir, Sinem; Melek, Ismet; Yanmaz, RasimObjective: To determine the prevalence of silent cerebral infarct and abnormal brain magnetic resonance imaging (MRI) findings in patients with sickle cell disease (SCD). Materials and methods: Fifty-two brain MR images of the asymptomatic patients with SCD have been reviewed retrospectively. The abnormal MRI findings were recorded. Results: Forty-four of the 52 patients with SCD were homozygous (S/S) and remaining 8 heterozygous (S/ßthal) for SCD. Twelve (27.2%) of the 44 patients with S/S and 2 (25%) of the 8 patients with S/ßthal had silent infarcts. Ten (22.7%; 7 diffuse cerebral, 2 focal cerebral and 1 cerebellum) of the 44 S/S patients demonstrated atrophy. None of the 8 patients with S/ßthal had cerebral atrophy. Conclusion: Patients with SCD living in Hatay demonstrated a high rate of silent cerebral infarct and cerebral atrophy. These findings concur with the results of the literature.Öğe Quantitative Brain Diffusion-Tensor MRI Findings in Patients With Sickle Cell Disease(Amer Roentgen Ray Soc, 2012) Balcı, Ali; Karazincir, Sinem; Beyoglu, Yeliz; Cingiz, Cihangir; Davran, Ramazan; Gali, Edip; Okuyucu, EsraOBJECTIVE. The aim of this study was to evaluate the microstructure of various regions of the brain using diffusion-tensor imaging (DTI) in patients with sickle cell disease (SCD) and in age- and sex-matched healthy control subjects. We also investigated the fiber tractography findings of the corpus callosum (CC) and corticospinal tracts (CSTs). SUBJECTS AND METHODS. Sixteen right-handed patients with SCD and 14 age- and sex-matched right-handed healthy control subjects were scanned using conventional MR sequences and DTI. Fractional anisotropy (FA) and apparent diffusion coefficients (ADCs) were calculated and regions of interest were selected in various brain areas (superior and inferior frontal, parietal, occipital, and temporal white matter areas), anterior and posterior periventricular areas, centrum semiovale, basal ganglia (lentiform nucleus, head of caudate nucleus), thalamus, cerebral peduncles, pons, cerebellar white matter areas, and CC. Diffusion-tensor tractography of the CC and CSTs was also performed. RESULTS. For the patients with SCD, significantly reduced FA values, increased ADC values, or both were seen clustered in several brain areas, including the CC, frontal white matter, centrum semiovale, periventricular areas, head of the caudate nucleus, thalamus, brainstem, and pons (p < 0.05). Statistically significant reductions in fiber counts in the first and fifth segments of the CC and in CSTs bilaterally were also observed in patients with SCD (p < 0.05). CONCLUSION. DTI shows microstructural abnormalities of various brain areas in patients with SCD.Öğe The relationship between Parkinson's disease and bone density(2016) Melek, İsmet; Dede, Hava Özlem; Duman, Taşkın; Okuyucu, Esra; Tamam, YusufAmaç: Parkinson hastalığı tanısıyla takipli hastalar artmış fraktur; özellikle femur başı frakturu riskiyle karşı karşıyadır. Bu risk artışının hastalığa özgü postural instabilite, nörolojik hasar ya da kemik mineral yoğunluğundaki azalmaya bağlanabileceği öne sürülmüştür. Parkinson hastalığında düşme sıklığı ve komplikasyonlarının artışı nedeniyle Parkinson hastalığı ve osteoporoz ilişkisi önemini korumaktadır. Bu nedenle Türk toplumundaki Parkinson hastalığıyla osteoporoz varlığı arasındaki ilişki incelemeye değer bulunmuştur. Gereç ve Yöntem: 65 idiyopatik parkinson hastasının dahil olduğu hasta grubu ile cinsiyet ve yaş aralığı uyumlu, bilinen sistemik hastalığı olmayan 30 bireyi kontrol grubu olarak kabul ederek kemik mineral yoğunluklarını karşılaştırdık. Kemik metabolizmasına etkisi olabilecek elektrolit ve metabolik hastalığa sahip bireyler çalışma dışı tutulmuştur. Parkinson hastalığı UPDRS ve Hoehn &Yahr skalalarına göre evrelendirilerek incelenmiştir. Bulgular: Çalışmanın sonucunda Parkinson hastaları grubunda anlamlı olarak kemik mineral yoğunluklarında kontrol grubuna göre azalma; ayrıca hastalık evresi Hoehn&Yahr skalasına göre arttıkça; hastaların immobilitesi arttıkça, kemik mineral yoğunluğunda azalma saptandı (p:0.037). Sonuç: Bu sonuçlar ışığında Parkinson hastalığı tanısıyla takipli bireylerde primer ve sekonder koruma tedavilerini planlarken osteoporoz ve olası komplikasyonların göz önünde bulundurulması gerektiğini vurgulamaktayız.Öğe Sickle cell disease with regional silent cerebral infarction detected by SPECT(Lippincott Williams & Wilkins, 2007) Yalcin, Hulya; Melek, Ismet; Okuyucu, Esra; Reyhan, Mehmet; Akguel, Ferit; Serarslan, Gamze; Duman, TaskinAn 18-year-old boy was admitted to the hospital for a right leg ulcer, which appeared 1 year ago. After physical and hematologic examinations, he was referred for neurologic and cardiologic examination because his hemoglobin analysis and hematologic findings were interpreted as being consistent with sickle cell anemia. Although he had no neurologic symptoms, MRI and Tc-99m ethyl cysteinate dimer cerebral perfusion single photon emission computer tomography were performed to rule out a silent cerebral infarction. Changes secondary to an infarct were seen in the region of the caudate nucleus.
