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    Öğe
    Clinical characteristics and treatment outcomes in patients with urticarial vasculitis
    (Kare Publ, 2021) Serarslan, Gamze; Okyay, Ebru
    OBJECTIVE: Urticarial vasculitis (UV) is an uncommon disease clinically presenting with pruritic urticarial plaques of the skin. The disease is classified as normocomplementic and hypocomplementemic types according to their complement levels. We aimed to evaluate demographic characteristics, laboratory findings, and response to treatment of patients diagnosed as UV in our clinic. METHODS: Between January 2015 and January 2019, the files of the patients were retrospectively reviewed. Demographic data, clinical features, laboratory findings, suspected triggering factors, disease course, treatment modalities, and treatment results of the patients were recorded. RESULTS: A total of 16 patients (nine males [56.25%], seven females [43.75%]) were included in the study.The mean age at diagnosis was 45.2 +/- 10.4 years and the duration of the disease was 72.1 +/- 62 months. Twelve (75%) patients had angioedema and two (12.5%) patients had residual hyperpigmentation. The most common extracutaneous finding was arthralgia (43.7%). No hypocomplementemia was detected in the patients. The most common abnormal laboratory findings were CRP elevation (37.5%) and ANA positivity (n=4/15, 26.7%). Analgesic and antibiotic drugs use were the most common possible triggering factors for the disease (n=9, 56%). Oral antihistamines, oral corticosteroids, azathioprine, colchicine, dapsone, hydroxychloroquine, doxepin, and omalizumab were among the treatments given to the patients. Complete remission was achieved in three patients. CONCLUSION: Compared with other studies, we found that angioedema was more frequent, postinflammatory hyperpigmentation was lower and long-term treatment was needed to control UV attacks. There are a few studies on UV and we think that more and larger patient groups are needed for standardization of treatment.
  • Küçük Resim
    Öğe
    Role of adiponectin and leptin in patients with alopecia areata with scalp hair loss
    (Springer London Ltd, 2021) Serarslan, Gamze; Ozcan, Oguzhan; Okyay, Ebru; Unlu, Bahar; Karadag, Mehmet
    Background/aims Alopecia areata (AA) is considered an organ-specific autoimmune disease of hair follicles. Adipose tissue plays a role in lipid metabolism and glucose metabolism and secretes adipokines such as leptin and adiponectin. Dysregulation in the adipokine balance may be associated with metabolic syndrome. We aimed to determine serum adipokine levels in AA patients and compare them with healthy controls, and to determine whether there was metabolic syndrome and insulin resistance in the AA patients. Methods A total of 70 participants were included in the study. Patients were divided into two subgroups: patients with scalp hair loss were in subgroup 1 (AA1). Patients with beard and eyebrow hair loss were in subgroup 2 (AA2). Serum adiponectin, leptin, TNF-alpha, insulin, fasting glucose, TG, and HDL were analyzed. Results Thirty-six (25 male, 11 female) patients with AA and 34 (18 male, 16 female) healthy subjects were included in the study. Metabolic syndrome was detected in three of the AA patients and in two of the healthy subjects. Serum leptin, adiponectin, TNF-alpha, TG, HDL, and insulin levels and HOMA-IR scores were not statistically significant in patients compared with control subjects, except fasting glucose levels (p = 0.035). However, serum leptin and adiponectin levels were significantly higher in AA1 (n = 25) subgroup compared with the control group (p = 0.029,p = 0.026 respectively). There was a statistically significant increase in the fasting glucose level, while there were no differences in other parameters between the AA2 (n = 11) subgroup and the control group. Conclusions To our knowledge, this is the first report indicating that adiponectin and leptin probably has a role in the pathogenesis of AA with scalp hair involvement.
  • Küçük Resim
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    Vitiligolu hastalarda serum adipokin düzeyleri (Leptin, adiponektin) ve insülin direncinin araştırılması
    (Hatay Mustafa Kemal Üniversitesi, 2020) Okyay, Ebru; Serarslan, Gamze
    Amaç: Vitiligo patogenezinde inflamasyonun rol oynadığı düşünülmektedir. Son yıllarda, adipokin dengesindeki düzensizlik inflamasyon, metabolik sendrom ve takiben gelişen hastalıklar ile ilişkili bulunmuştur. Bu çalışma, vitiligo hastalarında metabolik sendrom (MetS) bileşenlerinin varlığını ve insülin direncini (IR) belirlemeyi ve sağlıklı kontrol grubuyla karşılaştırmayı amaçlamıştır. Ayrıca vitiligo hastalarında serum leptin, adiponektin, tümör nekroz faktörü-α (TNF-α) düzeylerinin belirlenmesi ve hastalık aktivitesi ve yaygınlığı ile ilişkilerinin değerlendirilmesi amaçlanmıştır. Yöntem: Bu prospektif çalışmaya Mustafa Kemal Üniversitesi Dermatoloji Polikliniğine başvuran 37 vitiligo hastası (20 erkek, 17 kadın) ve 32 sağlıklı birey (16 erkek, 16 kadın) dahil edilmiştir. Katılımcıların VKİ (vücut kitle indeksi) hesaplanarak, kan basıncı ve bel çevreleri ayrı ayrı ölçülmüştür. Serum HDL-kolesterol, trigliserid (TG), insülin, TNF- α, leptin ve adiponektin düzeyleri değerlendirilmiştir. IR, homeostatik model değerlendirmesi (HOMA) metodu ile belirlenmiştir. Bulgular: Vitiligo ve kontrol grupları arasında yaş, cinsiyet ve VKİ açısından anlamlı fark izlenmemiştir. Hasta grubunun %10,8'inde (n=4), kontrol grubunun %9,3'ünde (n=3) MetS saptanmıştır. MetS komponentleri açısından iki grup arasında istatistiksel olarak anlamlı fark bulunmamıştır. Leptin (9,07±3,44) ve insülin (8,54±5,09) düzeyleri ve HOMA-IR (1,82±1,23) değerleri vitiligo hastalarında anlamlı olarak daha yüksek bulunmuştur (sırasıyla p=0,004; p=0,041; p=0,041). Vitiligo hastalarında kontrol grubuna göre adiponektin düzeyleri düşük ve TNF-α düzeyleri yüksek bulunmuş olmasına karşın iki grup arasında istatistiksel olarak anlamlı fark tespit edilmemiştir (sırasıyla p=0,885; p=0,110). Hastalık aktivitesi ve yaygınlığı ile serum adipokin düzeyleri arasında istatistiksel olarak anlamlı korelasyon saptanmamıştır. Sonuç: Proinflamatuar etkili leptinin yüksek bulunması vitiligo patogenezinde inflamasyonun rol oynadığı hipotezini desteklemektedir. HOMA-IR değerlerinin ve leptin düzeylerinin her ikisinde de görülen yükseklik vitiligonun insülin direnci ile ilişkili olduğunu göstermiştir.