Yazar "Onder, Arif" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ N/A ]
    Öğe
    The Role of Trigeminal Ganglion Neuron Density in the Prevention of Subarachnoid Hemorrhage-induced Basilar Artery Vasospasm: An Experimental Study
    (Lippincott Williams & Wilkins, 2009) Onder, Arif; Serarslan, Yurdal; Aydin, Mehmet Dumlu; Aydin, Nazan; Ulvi, Hizir; Kotan, Dilcan; Aygul, Recep
    Objective: Cerebral arteries innervated by several systems contribute to the control of cerebral blood flow. Sensory fibers of the trigeminal nerve have a vasodilatory effect on the basilar artery. Subarachnoid hemorrhage (SAH) causes severe cerebral vasospasm by various neurochemical mechanisms. We examined possible relationships between the neuron density of the trigeminal ganglion and the severity of basilar artery vasospasm in SAH. Methods: In this study, 28 rabbits were used. The animals were randomly divided into 3 groups: SAH (n = 18), serum physiologic (n = 5) and control (n = 5) groups. Experimental SAH was induced by injecting homologous blood into the cisterna magna. After 20 days, the basilar arteries and trigeminal ganglions were examined histopathologically. Basilar artery volumes and the neuron density of the ophthalmic divisions of the trigeminal ganglions were estimated stereologically, and the results were statistically analyzed. Results: The mean basilar artery volume was 4.15 +/- 0.19 mm(3) and the mean neuronal density of the trigeminal ganglion was 6500 +/- 750/mm(3) for the control group. These values were 4.05 +/- 0.29 mm(3) and 6400 +/- 584/mm(3) for the serum physiologic group, 3.80 +/- 0.35 mm(3) and 4600 +/- 300/mm(3) for living animals in the SAH group, and 2.26 +/- 0.29 mm(3) and 2950 +/- 618/mm(3) for dead animals in SAH group, respectively. A linear relationship was found between the neuronal density of the trigeminal ganglion and basilar artery volumes. Conclusions: The neuron density of the trigeminal ganglion may be an important factor in the regulation of basilar artery volume and for the continuation of cerebral blood flow. The low neuron density of the trigeminal ganglion may be involved in the pathogenesis of severe basilar artery vasospasm induced by SAH.
  • Küçük Resim
    Öğe
    Spinal Arachnoiditis and The Axonal Degeneration of The Spinal Nerve Roots Due to Ischemia Induced By Vasospasm: An Experimental Study
    (Journal Neurological Sciences, 2009) Onder, Arif; Serarslan, Yurdal; Aydin, M. Dumlu; Kanat, Ayhan; Gursan, Nesrin; Yolas, Coskun
    Objective: Various reasons have been ascribed to arachnoiditis development, among which subarachnoid hemorrhage (SAH) may be an important factor in this process. In this experimental study, we investigated the effect of SAH on histopathological findings. The volumetric changes of the radicular arteries and the density of spinal nerve root axons of a SAH model on C-4 roots in rabbits were measured. Materials and Methods: In this study, 18 rabbits were used. The animals were randomly divided into three groups: subarachnoid hemorrhage (SAH; n = 10), physiologic serum (SF; n = 4) and control (n = 4) groups. SAH was performed by injecting 0.5 cc of blood into cisterna magna taken from their auricular veins. Cervical spinal nerve roots at the C-4 level were examined histopathologically. Results: Meningeal thickening and adhesions, reddish spinal cord and radices were detected macroscopically. Histopathologically, leptomeningeal adhesions, intimal lesions of radicular arteries and axonal injury were detected at the nerve radices. The mean radicular artery volume was found to be low on the arachnoiditis developing animals. The mean alive axon density of the C-4 nerve root decreased and axonal degeneration was observed in the SAH group. Conclusion: Our study suggests that SAH may be an important etiologic factor in spinal arachnoiditis.