Yazar "Onmaz, A.C." seçeneğine göre listele

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    Effects of 2, 4-D (dichlorophenoxyacetic acid) on blood anti-oxidant / oxidant balance and on tissues in lambs
    (2010) Aytekn, I.; Onmaz, A.C.; Alp, H.; Ulucan, A.
    In this study, the effects of the common herbicide 2,4-D (dichlorophenoxyacetic acid) on blood antioxidant / oxidant status and on various organs were investigated in Sakiz crossbred lambs. For that, 6 lambs were poisoned accidentally with the herbicide whereas 6 other healthy animals served as negative controls and plasma MDA and GSH concentrations as well as serum ascorbate, retinol and ?-carotene concentrations were determined by spectrophotometry two days later. In parallel, conventional histological analysis was performed on lungs, liver, kidney and heart from a lamb dead after 2,4-D exposure. Blood antioxidant/oxidant balance was altered due to a significant increase of MDA concentrations coupled to a significant decrease of GSH concentrations in intoxicated lambs compared to controls. Congestive lesions and some haemorrhages were evidenced in lungs and kidneys and cell degeneration associated with lymphocyte infiltrate were observed in liver, kidneys and in heart. These results highly suggest that the herbicide 2.4-D induces an oxidative stress leading to cell destructions and tissue injury.
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    Effects of accidental ammonium Sulphate poisoning on antioxidant / oxidant status in lambs
    (2011) Aytekin, I.; Onmaz, A.C.; Ulucan, A.; Alp, H.
    In this study, the effects of the ammonium sulphate intoxication on the blood antioxidant /oxidant status were investigated in Sakiz crossbred Iambs. For that, circulating blood urea nitrogen (BUN), nitric oxide (NO), malondialdehyde (MDA), glutathione (GSH), ?-carotene, retinol and ceruloplasmin concentrations were measured in 6 lambs accidentally poisoned with ammonium sulphate and in 6 healthy control lambs. Oral treatment with 10% glutamic acid (lg/kg), 2.5% acetic acid (2.5 mL/kg) and vitamin A (400 IU/kg) was daily administered to diseased animals for five days. Poisoned lambs exhibited neurological signs (sleepiness, ataxia, tonic and clonic spasms) coupled to a rumen atony and acceleration of heart and respiratory rates compared to healthy controls. Biochemically, the circulating MDA, NO and BUN concentrations were markedly increased and the GSH, ?-carotene and vitamin A concentrations were significantly depressed compared to healthy controls whereas the ceruloplasmin concentrations were not significantly altered. After treatment, clinical and biochemical signs were significantly alleviated but, however 2 lambs died. For them, the histopathological examinations after haematoxylin-eosin staining revealed cell degeneration in liver, lungs and kidney associated to mononuclear cell infiltrates and proliferation of Küpffer cells. These results clearly showed the occurrence of an oxidative stress induced by ammonium sulphate poisoning leading to cell damage and proved the efficiency of a treatment based on organic acids and retinol supplementation.