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    Corneal biomechanical parameters in systemic autoimmune diseases
    (Taylor & Francis Ltd, 2022) Ozarslan Ozcan, Deniz; Ozcan, Sait Coskun; Kimyon, Gezmis
    Background This study aims to evaluate corneal biomechanical changes in patients with systemic autoimmune diseases using Corvis ST. Methods This prospective study included 36 patients with ankylosing spondylitis (AS), 38 patients with rheumatoid arthritis (RA), and 36 age- and sex-matched healthy subjects. After ophthalmologic examinations Pentacam HR and Corvis ST was performed on all eyes. The mean keratometric and pachymetric data, corneal biomechanical parameters, biomechanical intraocular pressure (bIOP) were analysed. Results There was no statistically significant differences among the groups regarding age, gender, refraction, visual acuity, IOP, pachymetry and keratometry. Compared to healthy controls, the mean velocity values of applanation 1 (A1V) and 2 (A2V), deformation amplitude (DA), and corvis biomechanical index (CBI) were statistically significantly higher and stiffness parameter at first applanation (SPA1) was statistically significantly lower in AS and RA patients (all p < 0.05). In both AS and RA groups, disease duration was found to be negatively correlated with SPA1 (p = 0.043, 0.027, respectively) and positively correlated with CBI (p = 0.022, 0.020, respectively). Conclusion AS and RA patients have a decreased corneal stiffness compared to healthy subjects. Disease duration seems to be correlated with these changes.
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    Öğe
    Paracentral sterile ring infiltrate after corneal crosslinking in a child
    (Lippincott Williams and Wilkins, 2021) Coskun Ozcan, Sait; Ozarslan Ozcan, Deniz
    A child with a paracentral sterile ring infiltrate presenting 3 days after corneal crosslinking (CXL) surgery for keratoconus is reported. The uninterrupted ring-shaped infiltration was seen along the epithelial healing margin in the paracentral cornea. The infiltration was approximately 120 µm deep in the anterior stroma and had sharply defined edges. Swab samples showed negative results. Sterile corneal infiltrate was diagnosed, and the patient was started on topical steroids in addition to the current treatment. The infiltration gradually resolved in the follow-up examinations. Visual loss or permanent corneal haze was not observed at the first month postoperatively. Patients should be carefully evaluated for complications such as sterile infiltrates in the short-term after CXL. An immune response mechanism triggered by the combination of epithelial healing, individual’s hypersensitivity, and UV-A irradiation may be etiologically responsible. Copyright © 2021 Published by Wolters Kluwer on behalf of ASCRS and ESCRS Published by Wolters Kluwer Health, Inc.