Yazar "Ozcil, Mustafa Dogan" seçeneğine göre listele

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    Comparison of Feto-maternal Effects of Twin Pregnancies and Twin Pregnancies Caused By Assisted Reproductive Technology
    (Galenos Yayincilik, 2021) Ozcil, Mustafa Dogan
    Objective: Comparison of the effects of twin pregnancies using assisted reproductive technology (ART) and spontaneous twin pregnancies on maternal-fetal parameters. Methods: A total of 5,670 patients who were deliveried in our clinic between 01.01.2011 and 31.12.2017 were analyzed retrospectively. The fetomaternal results of 94 mothers who deliveried to twins and their infants were compared. Results: Of the 5,670 patients who gave birth, 94 were twins (1/60) and 8 were triplets (1/709). Twin births account for 92% of multiple births. The incidence of spontaneous twin pregnancy was 1/77 and constituted 79% of all the twin deliveries. The effect of ART on was found to be 21% [17% in vitro fertilization (IVF), 4% ovulation induction]. Mean maternal age was 29.25 +/- 6.00 years in twin pregnancy deliveries, 28.50 +/- 6.09 years in mothers who had spontaneous twin group, and 32.54 +/- 5.09 years in twin births due to ART. When anemia was excluded, maternal morbidity was 27% in twin pregnancy deliveries. Pre-eclampsia was determined in 19% of the cases and anemia in 63%. Delivery before 37 gestational weeks was recorded in 72.3% of IVF twins and 70.2% of spontaneous twins. The rate of live births was found to be higher in spontaneously conceived twins (p=0.004). The fetal mortality rate was 5.4% in spontaneous twin pregnancies and 20% in twin pregnancies with ART (p=0.003). The perinatal mortality index was determined to be 81 in spontaneously conceived twins, and 250 in the twin pregnancies obtained with ART (p=0.006). Conclusion: Premature birth and fetal mortality rates are higher in twin pregnancies obtained with ART than in spontaneous twins. The mortality associated with multiple pregnancies may be reduced with preventive measures such as low-dose gonadotropin use, single embryo transfer, and multifetal embryo reduction.
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    Evaluation of ovarian reserve in Hashimoto's thyroiditis
    (Informa Healthcare, 2014) Tuten, Abdullah; Hatipoglu, Esra; Oncul, Mahmut; Imamoglu, Metehan; Acikgoz, Abdullah Serdar; Yilmaz, Nevin; Ozcil, Mustafa Dogan
    Human ovary is commonly the target of an autoimmune attack in cases of organ-or non-organ-specific autoimmune disorders. Hashimoto's thyroiditis (HT) is likely to be associated with ovarian dysfunction and diminished ovarian reserve. In this study, we aimed to evaluate the possible negative association between this significantly prevalent autoimmune disease and the ovarian reserve. Thirty-two premenopausal women with primary hypothyroidism, who under replacement therapy with thyroxine were recruited. Forty-nine healthy female subjects who had normal anti-thyroid antibody levels and were comparable with the HT group in terms of age and BMI values, comprised the control group. There was no statistically significant difference between the study and the control patients in terms of antral follicle count. Serum anti-Mullerian hormone (AMH) levels were significantly higher in woman with HT compared to the control group. The results of this study found no impairment in ovarian reserve parameters of patients with HT. Interestingly, the results revealed a significant increase in serum AMH levels of the patients with HT compared to controls. Hashimoto's thyroiditis may share a common etiologic linkage with polycystic ovary syndrome; therefore, leading to elevated serum AMH levels, which we are currently unable to define elaborately.
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    Latent ovarian stimulation in the management of infertile patients with hypogonadotropic hypogonadism Latent ovarian stimulation in hypogonadotropic hypogonadism
    (Bayrakol Medical Publisher, 2021) Ozcil, Mustafa Dogan
    Aim: This study was designed to determine the effects of different treatment approaches on clinical pregnancy and live birth rates in patients with infertility due to hypogonadotropic hypogonadism (HH). Material and Methods: The files of 31 patients with HH who applied with the complaint of infertility were retrospectively reviewed. Different infertility treatment protocols were applied to 21 of these cases, and the total number of cycles in which treatment was applied was recorded as 36. Of the 36 cycles, 22 were ovulation induction plus timed sexual intercourse, 3 were ovulation induction plus IUI, and the remaining 11 cycles were IVF/ICSI. Clinical pregnancy and live birth rates were determined as the primary outcome of our study. Results: Twelve (33% of 36 cycles) of 21 patients conceived and 9 (25% of 36 cycles) had a live birth. When subgroup analysis was performed, pregnancy was detected in 9 cases (41%; 9/22) in the OI group, while 6 cases (27%; 6/22) had live births. In the IUI group, pregnancy was detected in 2 cases (66%; 2/3) and live birth in 2 cases (66%). In the IVF group, pregnancy was detected in only 1 case (9%). and live birth- in 1 case (9%; 1/11). Two out of 3 patients who received 75 IU / day latent ovarian stimulation with HMG for 3 months became pregnant. Discussion: Latent ovarian induction with low doses of HMG in infertile patients with HH sensitizes developing follicles to exogenous gonadotropins and contributes to clinical pregnancy and live birth rates.
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    Relation of inflammatory markers with both presence and severity of hyperemesis gravidarum
    (Via Medica, 2014) Kurt, Raziye Keskin; Guler, Ayse; Silfeler, Dilek Benk; Ozcil, Mustafa Dogan; Karateke, Atilla; Hakverdi, Ali Ulvi
    Objectives: The aim of our study is to determine the newly introduced systemic inflammation marker, neutrophil lymphocyte ratio (NLR) in hyperemesis gravidarum (HG) patients and to investigate the association between severity of the disease and NLR. Method: The study population consisted of 55 pregnant patients with HG and 50 pregnant women without complaints matched for gestational age as a control group. The HG patients were grouped as mild (n=16), moderate (n=19) and severe (n=20) according to Modified Pregnancy-Unique Quantification of Emesis and Nausea Scoring Index Questionnaire. Furthermore, hsCRP, neutrophils, lymphocytes, and NLR were evaluated with complete blood count. Results: The HG group had significantly higher NLR values compared to the control group (2.69 +/- 1.81 vs 1.97 +/- 1.34, p=0.004). HsCRP levels were significantly higher among HG patients compared to the control group (1.95 +/- 2.2 vs 0.56 +/- 0.30, p<0.001). The subgroup analysis revealed statistically significant increases in NLR and hsCRP values with increased HG severity (p<0.001, p=0.002). The correlation analysis demonstrated a strong correlation between NLR and hsCRP levels (r: 0.703, p<0.001). Conclusion: Our study results showed that NLR and hsCRP levels are increased in HG disease compared to gestational age matched control group subjects. Furthermore, NLR and hsCRP values are correlated with severity of disease. NLR could be used as a marker for both presence and severity of hyperemesis gravidarum.