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Öğe Beta-lactamase Enzymes of Clinical Pseudomonas aeruginosa Strains(Univ West Indies Faculty Medical Sciences, 2016) Pasa, O.; Ozer, B.; Duran, N.; Inci, M.; Yula, E.Objectives: In this study, the production of extended spectrum beta-lactamase (ESBL), metallo-betalacatamase (MBL) and AmpC beta-lactamase enzymes of Pseudomonas aeruginosa (P aeruginosa) strains which were isolated from clinical samples were investigated. AmpC gene was also detected by the polymerase chain reaction (PCR) analysis. Methods: A hundred strains of P aeruginosa were included in the study. The presence of ESBL was investigated with combined disk confirmation test, MBL was investigated with E-test method and AmpC beta-lactamase was investigated with disk induction test. In order to detect the production of AmpC beta-lactamase genotypically, the PCR method was used. Results: Only one strain was found to be MBL positive. Four per cent of strains were found to be ESBL positive. AmpC beta-lactamase production was positive in 73% of the strains with disk induction test. AmpC gene was detected in 96% of the studied strains with the PCR method. Conclusion: While ESBL and MBL rates in this study were significantly lower than those found in other studies, the rate of AmpC beta-lactamase was higher. Although AmpC gene was detected in some strains (23%), they were not found to produce AmpC beta-lactamase with disk induction test.Öğe For how many times can a partially absorbable monofilament mesh be sterilized? In vitro experimental study(Springer Wien, 2013) Ozkan, O. V.; Aydogan, A.; Akkucuk, S.; Aydin, M.; Nacar, E.; Ozer, B.; Mistikoglu, S.We investigated the effects of hydrogen peroxide gas plasma resterilization (HPS) on partially absorbable monofilament meshes in terms of their mechanical properties and risk of infection. A mesh was divided into small pieces which were categorized as HPS-1, HPS-2 and HPS-3 according to the number of HPS. To assess the strength of specimens, maximum load, elongation at maximum load and quantity of energy required for complete failure of the specimens were measured. Microbiological and ultrastructural analyses were also performed. There was not a significant relationship between control and HPS-1, HPS-2 groups in terms of maximum load and quantity of energy required for complete failure of the specimens. However, those parameters were statistically different between HPS-3 and control groups. We observed minor morphological changes in the HPS-3 group when compared to those of the control group. No risk of infection was detected by microbiological tests. It is advisable to apply HPS to partially absorbable monofilament meshes no more than twice since sterilization for three times leads to degeneration in mesh structure and strength.Öğe Identification of Helicobacter pylori by Urea Breath test and serology in the patients with psoriasis(Wiley-Blackwell, 2016) Balci, D. D.; Yalcin, H. Peker; Ozer, B.; Duran, N.; Inan, M. U.; Yenin, J. Z.[Abstract Not Available]Öğe In vitro antileishmanial activity of Adana propolis samples on Leishmania tropica(Springer, 2008) Duran, G.; Duran, N.; Culha, G.; Ozcan, B.; Oztas, H.; Ozer, B.Propolis (bee glue) is a natural resinous hive product, collected from various plant sources. It has attracted much attention as a useful substance applied in medicine due to its pharmacological activities. It was aimed to investigate the in vitro effects of an ethanolic extract of Adana propolis samples on the growth of Leishmania tropica. Parasite cells were treated with five concentrations (25, 50, 100, 50, 500, and 750 mu g/ml) of the propolis. The number of promastigotes in each concentration was calculated using a hemocytometer slide at 24, 48, and 72 h after being harvested. In the experiments, it was determined that the concentrations up to 100 mu g/ml of the propolis did not exhibit antileishmanial activity against the parasites cells. At these concentrations, there was no changes in terms of morphologically. In addition, there was no statistically significant difference in terms of cell count between control and these three groups (p > 0.05). However, in culture media containing the propolis samples at 250, 500, and 750-mu g/ml concentrations, statistically significant differences in cell counts were observed, as compared to the control group (p < 0.05). Our results demonstrate that ethanolic extracts of Adana propolis samples reduce the proliferation of L. tropica parasites significantly.Öğe The prevalence of interdigital erythrasma in southern region of Turkey(Wiley-Blackwell, 2012) Inci, M.; Serarslan, G.; Ozer, B.; Inan, M. U.; Evirgen, O.; Alagoz, G. Erkaslan; Duran, N.Background Erythrasma is a skin infection which is caused by Corynebacterium minutissimum. Interdigital erythrasma is the most common form. Objective The aim of this study was to detect the frequency and risk factors of interdigital erythrasma in patients with clinically suspected tinea pedis. Methods This study was conducted between June and December 2010 and included 122 patients who had interdigital foot lesions. All patients were examined using a Woods lamp. The smears were stained using Grams method. Direct examination was performed using 20% potassium hydroxide. Sabouraud dextrose agar and brain heart infusion agar were used for cultures. Moreover, the demographical characteristics of patients, concomitant diseases and clinical findings were also recorded. Cases that were found to be positive on Woods lamp examination and/or Gram staining/culture were considered as erythrasma. Results The rate of erythrasma was found to be 46.7%. The mean age was 43.6 years, and the disease was more prevalent in men. The most common clinical finding was desquamation. Mycological examination was found as positive in 40.35% of the patients. No growth was observed in bacteriological cultures. It was found that using only Woods lamp examination or Gram staining resulted in 11 (9%) and 19 positive patients (15.6%), respectively, whereas using both Woods lamp examination and Gram staining concurrently resulted in 27 positive patients (22.1%). Conclusion Interdigital erythrasma is a commonly seen condition and can clinically mimic tinea pedis. A Woods lamp is a good diagnostic tool, but Gram staining, particularly in those with a negative Woods lamp result, may be a useful method.Öğe Prevalence of Toxoplasmosis, Cytomegalovirus and Rubella IgG Antibodies in Hatay Women and Children(Univ West Indies Faculty Medical Sciences, 2012) Koksaldi-Motor, V.; Evirgen, O.; Azaroglu, I.; Inci, M.; Ozer, B.; Arica, S.Objective: Toxoplasmosis, cytomegalovirus and rubella may cause congenital infections. The aim of this study is to investigate toxoplasmosis, cytomegalovirus and rubella IgG antibodies in women and children who were admitted to the Hatay Women and Children Hospital between January 1 and December 31, 2009. Methods: Levels of IgG antibodies for toxoplasmosis, cytomegalovirus and rubella established with chemiluminescence immunoassay (Architect i2000, Abbott, USA) method were evaluated, retrospectively. Results: The results were obtained from 1103 cases. Seropositivity of IgG antibodies for toxoplasmosis (n = 743), cytomegalovirus (n = 929) and rubella (n = 746) were 59.9%, 98.9% and 93.6%, respectively. Conclusion: Routine serological screening should be recommended in women of childbearing age. Seronegative subjects should be vaccinated for rubella and educated for protection from toxoplasmosis.Öğe The relationship between anti-cyclic citrullinated peptide and bone mineral density and radiographic damage in patients with rheumatoid arthritis(Taylor & Francis Ltd, 2008) Guler, H.; Turhanoglu, A. D.; Ozer, B.; Ozer, C.; Balci, A.Objectives: We aimed to investigate the relationship between anti-cyclic citrullinated peptide (anti-CCP) levels and bone mineral density (BMD), bone turnover, and radiographic damage in patients with rheumatoid arthritis (RA). Methods: Eighty patients (68 females, 12 males, mean age 46.50 +/- 14.59 years) with RA were included in the study. Anti-CCP antibodies were measured by enzyme-linked immunosorbent assay (ELISA). Bone turnover was studied by analysing serum levels of C-terminal telopeptide of type I collagen (sCTX, ng/mL), using an enzyme immunoassay. BMD was measured by dual-energy X-ray absorptiometry (DXA). Disease activity was assessed according to the Disease Activity Score that includes 28 joint counts (DAS28). Functional capacity was assessed by the Health Assessment Questionnaire (HAQ). Results: Anti-CCP-positive patients were defined as group 1 and anti-CCP-negative patients as group 2. The mean disease duration was 7.53 +/- 6.27 years in group 1 and 6.25 +/- 6.51 years in group 2. Anti-CCP had a limited negative correlation with lumbar BMD (r=-0.220, p=0.050) and a negative correlation with femoral BMD (r=-0.242, p=0.031). There was no statistically significant correlation between anti-CCP and sCTX values (r=0.117, p=0.301). Sharp scores were significantly higher in anti-CCP-positive than anti-CCP-negative patients (p=0.012), and anti-CCP levels were significantly correlated with Sharp scores (r=0.240, p=0.032). Conclusions: We found that RA patients with higher levels of anti-CCP antibody had lower lumbar and femoral BMD. Anti-CCP levels were also associated with radiographic damage. Therefore, we suggest that anti-CCP may be a determinant of bone loss in patients with RA.
