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Öğe IMPROVED IRON CHELATION WITH DEFERASIROX AND ZINC COMBINATIONAL THREAPY IN PATIENTS WITH BETA THALASSEMIA MAJOR: IS IT ADDITIVE OR SYNERGISTIC?(Ferrata Storti Foundation, 2012) Unal, S.; Celik, T.; Ozer, C.; Ilhan, G.; Oktay, G.[Abstract Not Available]Öğe Practical cut off values to determine body mass index(2008) Helvaci, Mehmet Rami; Ozer, C.; Kaya, H.; Yalcin, A.We tried to understand whether there are significant cut off values simply determining body mass index (BMI). The study was performed in Internal Medicine Polyclinics on consecutive check up patients aged between 15 and 70 years to see possible consequences of excess weight on health and to avoid debility induced weight loss in elders. Insulin using diabetics and patients with devastating illnesses were excluded to avoid their possible effects on weight. Cases were subdivided into three groups according to their body weights as under 65, between 65 and 85, and above 85kg groups and prevalences of underweight, normal weight, overweight, and obesity were determined. Sensitivity, specificity, and positive and negative predictive values of body weights to determine BMI were calculated. The study included 954 cases (566 females). Sensitivity of 65kg as a cut off value to detect normal weight was 61.0%, specificity 94.3%, positive predictive value 82.9%, and negative predictive value was 97.6%. Similarly, sensitivity, specificity, and positive and negative predictive values of 65 and 85kg to detect overweight cases were 71.5%, 63.3%, 56.2%, and 77.1% respectively. So both values were statistically significant to detect normal weight, overweight and obese individuals (p=0.000 for both). Although BMI is probably a more valuable parameter to show weight status, the cut off values of 65 and 85kg, as an easier way, have significant places, too.Öğe The relationship between anti-cyclic citrullinated peptide and bone mineral density and radiographic damage in patients with rheumatoid arthritis(Taylor & Francis Ltd, 2008) Guler, H.; Turhanoglu, A. D.; Ozer, B.; Ozer, C.; Balci, A.Objectives: We aimed to investigate the relationship between anti-cyclic citrullinated peptide (anti-CCP) levels and bone mineral density (BMD), bone turnover, and radiographic damage in patients with rheumatoid arthritis (RA). Methods: Eighty patients (68 females, 12 males, mean age 46.50 +/- 14.59 years) with RA were included in the study. Anti-CCP antibodies were measured by enzyme-linked immunosorbent assay (ELISA). Bone turnover was studied by analysing serum levels of C-terminal telopeptide of type I collagen (sCTX, ng/mL), using an enzyme immunoassay. BMD was measured by dual-energy X-ray absorptiometry (DXA). Disease activity was assessed according to the Disease Activity Score that includes 28 joint counts (DAS28). Functional capacity was assessed by the Health Assessment Questionnaire (HAQ). Results: Anti-CCP-positive patients were defined as group 1 and anti-CCP-negative patients as group 2. The mean disease duration was 7.53 +/- 6.27 years in group 1 and 6.25 +/- 6.51 years in group 2. Anti-CCP had a limited negative correlation with lumbar BMD (r=-0.220, p=0.050) and a negative correlation with femoral BMD (r=-0.242, p=0.031). There was no statistically significant correlation between anti-CCP and sCTX values (r=0.117, p=0.301). Sharp scores were significantly higher in anti-CCP-positive than anti-CCP-negative patients (p=0.012), and anti-CCP levels were significantly correlated with Sharp scores (r=0.240, p=0.032). Conclusions: We found that RA patients with higher levels of anti-CCP antibody had lower lumbar and femoral BMD. Anti-CCP levels were also associated with radiographic damage. Therefore, we suggest that anti-CCP may be a determinant of bone loss in patients with RA.Öğe Sperm retrieval by microdissection testicular sperm extraction and intracytoplasmic sperm injection outcomes in nonobstructive azoospermic patients with Klinefelter syndrome(Wiley, 2018) Ozer, C.; Aytac, P. Caglar; Goren, M. R.; Toksoz, S.; Gul, U.; Turunc, T.Klinefelter syndrome is the most frequent chromosomal abnormality in patients with nonobstructive azoospermia. The development of advanced assisted reproductive techniques, such as testicular sperm extraction and intracytoplasmic sperm injection, has provided the possibility of biological fathering in nonobstructive azoospermic patients with Klinefelter syndrome. We aimed to evaluate our sperm retrieval rate by microdissection testicular sperm extraction and to analyse the intracytoplasmic sperm injection outcomes in these patients. Medical records of 110 nonobstructive azoospermic patients with Klinefelter syndrome were retrospectively reviewed. We found that the sperm retrieval rate by microdissection testicular sperm extraction is lower than published reports on other types of secretory azoospermia. The statistical analyses yielded that age, FSH and testosterone levels as predictive factors for successful sperm retrieval.
