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Anxiety, depression and quality of life in patients with beta thalassemia major and their caregivers
(E-Century Publishing Corp, 2014) Yengil, Erhan; Acipayam, Can; Kokacya, Mehmet Hanifi; Kurhan, Faruk; Oktay, Gonul; Ozer, Cahit
Mental health and health related quality of life is commonly affected in patients with chronic problems and their caregivers. In the present study, it was aimed to assess depression and anxiety in patients with beta thalassemia major (BTM) and in their caregivers; and to evaluate effects of these disorders on quality of life. The study was carried out in a district Hereditary Hemoglobinopathy Center and included 88 patients with BTM and 63 of their caregivers. All subjects were assessed using Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Short Form-36 (SF-36) by a trained psychiatry resident via face-to-face interview. The BDI scores were 17 or above in 20.5% of the patients with BTM and 28.6% of their caregivers (P = 0.248). Of the patients with BTM, there were mild anxiety symptoms in 19.3%, while moderate and severe anxiety symptoms in 14.8% and 4.5%, respectively. Anxiety levels were similar between the patients with BTM and their caregivers (P = 0.878). It was found that BDI and BAI scores were negatively correlated to scores of physical health and mental health components of SF-36 in patients with BTM and their caregivers. In linear regression analysis, it was seen that depression affected physical and mental health of the patients with BTM and their caregivers regardless from anxiety. BTM leads an increase in the frequency of depression and anxiety in both patients and their caregivers, and affects negatively physical and mental components of quality of life.
Bronchoscopy for foreign body aspiration and effects of nebulized albuterol and budesonide combination
(Professional Medical Publications, 2017) Akcora, Bulent; Celikkaya, Mehmet Emin; Ozer, Cahit
Objective: A foreign body aspiration in the tracheobronchial tree is a dangerous medical condition in the childhood period. Although rigid bronchoscopy is a safe procedure, it may cause complications. The aim of this study was to present our bronchoscopy experience and to evaluate the efficacy of pre-operative administration of nebulized albuterol and budesonide combination for reducing intra-operative complications in foreign body aspirated cases. Methods: In this retrospective study our pediatric cases in which a foreign body was removed from tracheobronchial tree in last 8 years were analyzed. After excluding the patients who needed emergent and negative bronchoscopies, the remaining clinically stable 84 patients were compared for the effects of preoperative administration of nebulized albuterol and budesonide combination on bronchoscopy complications. Results: There were 51 boys (60.3%) and 33 girls (39.7%). There were 38 children in the non-nebulized group and 46 children in the nebulized group. We found that the combined albuterol and budesonide nebulization decrease complications such as arterial oxygen desaturation (p<0.05), and bronchospasm (p<0.05) during the bronchoscopic intervention. Conclusion: Preoperative nebulization of albuterol and budesonide combination may decrease perioperative complications of bronchoscopy.
CAN FOOT PAIN AND MUSCULOSKELETAL DISORDERS BE COUNTED AS RISK FACTORS FOR FALLS IN THE ELDERLY?
(Gunes Kitabevi Ltd Sti, 2010) Turhanoglu, Ayse Dicle; Guler, Hayal; Kalici, Aydiner; Inanoglu, Deniz; Ozer, Cahit
Introduction: In this study, it was aimed to determine whether musculoskeletal disorders (FMDs) and/or foot pain (FP) were risk factors for falls and deteriorating health status in the elderly. Materials and Method: Two hundred fifty five patients aged over 60 years were enrolled in the study. The elderly filled the questionnaire about FP and falling. The FMDs in the study included hallux valgus (HV), hammer toe (HT), mallet toe (MT), claw toe (CT), overlapping toe (OT), pes cavus (PC), pes planus (PP), metatarsalgia (MA) and plantar fasciitis (PF). Participants' risk of falling was assessed using The Performance-Oriented-Mobility-Assessment and the health status was measured using The Short-Form (SF)-36. Results: A total of 255 patients with a mean age of 67.90 +/- 6.15 were examined; 175(69%) were female and 78 (31%) were male. Ninety-seven (38%) of the subjects reported FP and 103 (43.8%) patients were diagnosed as having FMDs. The most common FMD was HV (18.4%), followed by PF (15.9%), PP (13.3%), MA (12.9%), HT (7.8%), MT (4.3%), OT (3.5%), CT (1.6%) and PC (1.9%). FP, HV, PP, MA, PF, CT and OT were associated with risk of falling (p<0.05). There was a relationship between falls and the presence of FMD (p<0.01) and foot pain (p<0.01). PCSs of the patients with FP were lower than that of those without FP (p<0.05) Conclusion: FMDs and FP should be considered as risk factors for falling in the elderly.
Clinical presentation and laboratory findings of organic phosphorus poisoning
(Springer, 2007) Ozer, Cahit; Kuvandik, Guven; Gokel, Yuksel; Duru, Mehmet; Helvaci, Mehmet Rami
This study was conducted to evaluate the demographic, causative, and biologic characteristics of patients with organophosphate (OP) poisoning who were admitted to tertiary teaching and research hospitals at 2 different universities. All patients admitted to the emergency departments of Cukurova University Hospital in Adana, Turkey, between 2001 and 2003 and the Hospital of Mustafa Kemal University in Hatay, Turkey, between 2004 and 2006 were included. The study group consisted of subjects with a mean age of 28.5 +/- 14.1 y (range, 14-80 y), and the maximum number of cases in the second decade of life; the female-to-male ratio was 2.2:1. In all, 27 of 43 females and 16 of 20 males were married. Most subjects (n=55) had graduated from primary school; 3 were illiterate and 5 were highly educated. A total of 36 (57.1%) subjects belonged to lower socioeconomic groups. Fifty-three patients intended to commit suicide, and 10 cases were accidental. Mean arrival time of subjects to the hospital after poisoning was 9.9 +/- 16.1 h (range, 1-96 h); mean Glasgow Coma Scale score was 10.2 +/- 2.9 (range, 3-15). A total of 19 subjects were intubated, and 4 died. A total of 59 patients recovered completely. The mortality rate (6.3%) depended on various factors such as OP compound consumed, amount ingested, time interval before hospitalization, and patients' general health. Chances for recovery were greater when the patient was hospitalized at the earliest indication. In conclusion, ON especially affected young single females, and most cases were due to attempted suicide. Because OP poisoning is an important cause of morbidity and mortality, therapy should be started immediately to avoid undesirable consequences.
Comparison of Ketoprofen Phonophoresis with Ketoprofen and Lidocaine-Prilocaine Phonophoresis in Patients with Subacromial Impingement Syndrome
(Turkish League Against Rheumatism, 2009) Guler, Hayal; Turhanoglu, Ayse Dicle; Inanoglu, Kerem; Inanoglu, Deniz; Ozer, Cahit
Objective: The aim of the present study was to compare ketoprofen phonophoresis with ketoprofen and lidocaine-prilocaine phonophoresis in patients with subacromial impingement syndrome (SIS). Material and Methods: Seventy patients (39 female, 31 male) with SIS were included in this study. The patients were divided into two groups and a 15-session physical therapy and rehabilitation program was performed in each group. Ketoprofen and lidocaine-prilocaine phonophoresis were performed in the first group and ketoprofen phonophoresis alone in the second group. Hot pack, transcutaneous electrical nerve stimulation (TENS) and exercises were applied in all patients. Severity of shoulder pain was determined by visual analogue scale (VAS). Range of motion (ROM) was measured by goniometer. Functional capacity of patients was evaluated by UCLA (The University of California-Los Angeles) score. All of the measurements were performed before treatment and in the 1st and 3rd months after treatment. Results: There was no significant difference between the two groups in VAS and UCLA scores before treatment initiation (p>0.05). VAS scores of Group 1 were lower than of Group 2 (p=0.020) in the 3rd month follow-up. ROMs and flexion, abduction and internal rotation were higher in Group 2 than Group 1 (p=0.009, p=0.001, p=0.019, respectively) before treatment. Abduction measurements in Group 2 were higher than in Group 1 in the 1st month after treatment (p=0.024). However, there was no significant difference between the two groups in UCLA and ROM values in the 3rd month (p>0.05). There was also no significant difference between the two groups in external rotation values before and after treatment (p>0.05). Conclusion: Our study showed that ketoprofen and lidocaine-prilocaine phonophoresis were more effective on pain and ROM than ketoprofen phonophoresis alone in the 3rd month after treatment in patients with SIS. (Turk J Rheumatol 2009; 24: 88-93)
Comparison of sugammadex and conventional reversal on postoperative nausea and vomiting: a randomized, blinded trial
(Elsevier Science Inc, 2015) Koyuncu, Onur; Turhanoglu, Selim; Akkurt, Cagla Ozbakis; Karcioglu, Murat; Ozkan, Mustafa; Ozer, Cahit; Sessler, Daniel I.
Study Objective: To determine whether the new selective binding agent sugammadex causes less postoperative nausea and vomiting (PONY) than the cholinesterase inhibitor neostigmine. Design: Prospective, randomized, double-blinded study. Setting: University-affiliated hospital. Patients: One hundred American Society of Anesthesiologists physical status 1 and 2 patients scheduled for extremity surgery. Interventions: Patients were randomly assigned to neostigmine (70 mu g/kg) and atropine (0.4 mg per mg neostigmine) or sugammadex 2 mg/kg for neuromuscular antagonism at the end of anesthesia, when 4 twitches in response to train-of-four stimulation were visible with fade. Measurements: We recorded PONY, recovery parameters, antiemetic consumption, and side effects. Main Results: Nausea and vomiting scores were lower in the sugammadex patients upon arrival in the postanesthesia care unit (med: 0 [min-max, 0-3] vs med: 0 [min-max, 0-3]; P <.05), but thereafter low and comparable. Postoperative antiemetic and analgesic consumption were similar in each group. Extubation (median [interquartile range], 3 [1-3.25] vs 4 [1-3.25]; P <.001) first eye opening (4 [3-7.25] vs 7 [5-11]; P <.001), and head lift (4 [2-7.25] vs 8 [11-25]; P <.001) in minutes were shorter in patients given sugammadex. Postoperative heart rates were significantly lower in all measured times patients given neostigmine. Conclusions: Nondepolarizing neuromuscular blocking antagonism with sugammadex speeds recovery of neuromuscular strength but only slightly and transiently reduces PONY compared with neostigmine and atropine. (C) 2014 Elsevier Inc. All rights reserved.
Daytime sleepiness and sleep habits as risk factors of traffic accidents in a group of Turkish public transport drivers
(E-Century Publishing Corp, 2014) Ozer, Cahit; Etcibasi, Seref; Ozturk, Levent
Aim: To explore the association of daytime sleepiness, sleep complaints and sleep habits with self-reported car crashes among public transport drivers. Methods: A cross-sectional descriptive study was carried out on male professional public drivers in two different cities using a validated, self-administered sleep questionnaire which comprised of symptoms suggesting sleep disorders, a subjective report of daytime sleepiness and driving characteristics. The subjects (mean age +/- SD, 40 +/- 11 years) were divided into two groups: (1) accident group and (2) no accident group. Results: Forty nine (15.3%) of the 320 public drivers reported that they had at least one sleepiness related motor vehicle accident and/or near-missed accident (Group 1). The mean age, body mass index and annual distance driven were similar in both groups. Although Group 1 reported less sleep time per night, more witnessed apneas, abnormal sleep, alcohol use and had higher mean Epworth Sleepiness Scale scores than Group 2, multivariate analysis of risk factors revealed that only daytime sleepiness increase the risk of traffic accidents [OR: 1.32 (1.19-1.47)]. Conclusion: These results suggest that self-reported sleepiness is a predictive sign of traffic accidents due to driver sleepiness.
Dermoscopy in the Diagnosis of Cutaneous Leishmaniasis
(Int Dermoscopy Society, 2019) Serarslan, Gamze; Ekiz, Ozlem; Ozer, Cahit; Sarikaya, Gokhan
Background: Cutaneous leishmaniasis (CL) is a protozoan infectious disease. Dermoscopy is a noninvasive diagnostic tool that has been applied to several skin diseases, including infestations. Objectives: To determine the dermoscopic patterns of CL lesions and to investigate whether a relationship exists between dermoscopic characteristics and the disease duration, localization, and type of CL lesions. Methods: Seventy-nine patients (48 male, 31 female) from Hatay, Turkey, were enrolled in the study and a dermoscopic evaluation was performed on 139 lesions. Images of CL lesions were taken via polarized light contact dermoscopy. Chi-square and Fisher exact tests were used for statistical analyses and P values <0.05 were considered significant. Results: Generalized erythema was seen in all CL lesions. Vascular structures (94.2%), yellow tears (75.5%), and a white starburst-like pattern (58.3%) were the other most common dermoscopic features. Hyperkeratosis (P = 0.001) and white starburst-like pattern (P < 0.001) were more prevalent in the extremities than elsewhere. Among vascular structures, linear irregular (45.8%), hairpin (43.5%), and comma-shaped (25.9%) patterns were the most common dermoscopic findings. Linear irregular (P = 0.023) and arborizing vessels (P = 0.001) were observed in the head-neck region. Dotted (P = 0.009), hairpin (P < 0.001), and glomerular-like (P = 0.016) morphological findings were more prevalent in the extremities. Statistical significances in disease duration were detected in microarborizing (P = 0.027) and arborizing (P = 0.004) vessels and were most prevalent with a disease duration of >6 months. Hairpin vessels were prevalent in the plaque and nodulo-ulcerative type of lesions. Dotted vessels were most commonly seen in the plaque type (47.4%) of lesions. Conclusions: Generalized erythema, yellow tears, and starburst-like patterns, as well as linear irregular, hairpin, comma-shaped, and arborizing vessels, were the most commonly detected dermoscopic features of CL lesions. We suggest that the presence of these features can be helpful when diagnosing CL lesions by dermoscopy.
The Distribution of Intestinal Parasites among Turkish Children Living in a Rural Area
(Medi+World Int, 2008) Culha, Gulnaz; Ozer, Cahit
Background: The aim of this study was to determine the prevalence of intestinal parasites in children and to evaluate its association with socioeconomic and environmental factors. Methods: Stool samples and cellulose tape slides of children between 1-16 years of ages living in a rural area in Antakya were investigated. Stool samples were examined by using the direct wet mount, iodine method, and sedimentation techniques. Results: One hundred and ninentynine (51.3%) of the 388 children included in the study were male, and the mean age was 6,8 +/- 3,4 years (minimum 1, maximum 16). Most of the families (87.4 %) were from the lowest socio-economical level and almost all of the mothers (96.4%) were housewivfes. One hundred and fifty-three (39.4%) stool specimens and 114 (29.4%) cellulose tape slides were considered as positive. The most frequently detected parasites were Enterobius vermicularis (29.4%), Blastocystis hominis (19.8%), Giardia intestinalis (16.5%). No statistical significance was observed in relation to intestinal parasites detected in tape slides and stool samples and; gender (p=0,906 and p=0,751), maternal occupation (p=0,075 and p=0,410), paternal occupation (p=0,355 and p=0,354), conditions of the residence [i.e having a garden (p=0,185 and p=0,733) and stable (p=0,523 and p=0,851), water supply (p=0,675 and p=0,218), having pets or animals (p=0,856 and p=0,429), having a separate room for each sibling (p=0,927 and p=0,079)] and, having symptoms indicating intestinal parasites (p=0,126 and p=0,611). Conclusion: High prevalences of intestinal parasites in children living in lower socioeconomic conditions showed that parasitosis remains to be a public health problem in Antakya.
Dyslipidemia May Be An Indicator for Trend of Body Weight
(Medi+World Int, 2008) Helvaci, Mehmet Rami; Akdemir, Cihangir; Kaya, Hasan; Ozer, Cahit
Background: Prevalence of excess weight is increasing with a high cost on health worldwide. Methods: The study was performed in the Internal Medicine Polyclinic on routine check up patients, and consecutive patients at and above the age of 20 years were studied to permit growth of height in youngers. Results: The study included 1068 cases (628 females) totally. There were only 19 (1.7%) cases with underweight and 307 (28.7%) with normal weight, so 69.4% (742) of cases at and above the age of 20 years had excess weight. The prevalence of excess weight increased from 28.7% (52) in the third to 63.6% (100) in the fourth decades (p<0.001), and decreased from 87.0% (94) in the seventh to 78.5% (84) in the eighth decades (p<0.05). Similarly, prevalences of hyperbetalipoproteinemia, hypertriglyceridemia, and dyslipidemia showed similar patterns of tendency with the excess weight, by increasing in the fourth and decreasing in the eighth decades of life (p<0.05 in all). Conclusion: Prevalence of excess weight and dyslipidemia are increasing by decades, particularly in the fourth decade, and this increase turns to a decrease in the eighth decade of life. So 30th and 70th years of age may be the breaking points of life, both for dyslipidemia and body weight, and dyslipidemia may be a pioneer sign for tendency of body weight. Probably decreased physical and mental stresses after the age of 30th years and debility and comorbid disorders induced restrictions after the age of 70th years may be the major causes for the changes.
Effect of Coexisting Foot Deformity on Disability in Women with Knee Osteoarthritis
(Amer Podiatric Med Assoc, 2009) Guler, Hayal; Karazincir, Sinem; Dicle Turhanoglu, Ayse; Sahin, Gunsah; Bald, Ali; Ozer, Cahit
Background: Knee osteoarthritis, a common musculoskeletal disorder, can cause considerable pain and disability. This study investigates the effect of certain foot deformities on the functional status of women with knee osteoarthritis. Methods: The common foot deformities pes planus and hallux valgus were evaluated in 115 women with knee osteoarthritis and Kellgren-Lawrence grade 2 and 3 osteoarthritis. Anteroposterior and lateral foot-ankle standard radiographs were obtained bilaterally. A lateral talometatarsal angle greater than 4 degrees was defined as pes planus. A hallux valgus angle greater than 21 degrees was defined as hallux valgus. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was used to objectively assess functional impairment. Knee pain intensity was measured with a visual analog scale. Results: Fifty-nine patients had bilateral pes planus, hallux valgus, or both. The mean visual analog scale value was higher for the deformity group, but the difference was not statistically significant. There was a significant difference in WOMAC scores between the group with foot deformities versus the group without (P = .000). Visual analog scale scores were positively correlated with WOMAC scores (r = 0.499, P = .000). Also, there was a significant correlation between WOMAC scores and lateral talometatarsal angle (r = 0.266, P = .004) and hallux valgus angle (r = 0.362, P = .000) values. Conclusions: There is a significant correlation between indicators of pain and disability (visual analog scale and WOMAC scores). Also, the presence of foot deformities increased disability levels in women with knee osteoarthritis. (J Am Podiatr Med Assoc 99(1): 23-27, 2009)
Effectiveness of Booster Measles-Mumps-Rubella Vaccination in Lower COVID-19 Infection Rates: A Retrospective Cohort Study in Turkish Adults
(Dove Medical Press Ltd, 2021) Yengil, Erhan; Onlen, Yusuf; Ozer, Cahit; Hambolat, Mustafa; Ozdogan, Mehmet
Objective: The aim of this study was to investigate the effectiveness of booster vaccination of adults with measles-mumps-rubella in the COVID-19 infection rates. Methods: In order to investigate this hypothesis, we tested COVID-19 positivity rate through PCR assay on the participants (n=245; male), who had to share the same student accommodation together with the same dining hall to provide governmental service. Participants were divided into two groups based on their booster vaccination status with measles-mumps-rubella: the non-vaccinated group (n=207) and the vaccinated group (n=38). The rate of COVID-19 seropositivity, age, body mass index (BMI), active smoking and presence of comorbidity were also measured and recorded. Results: All of the participants were healthy, and age distribution, comorbidity rates, active smoking status and BMI did not vary significantly among the two groups (p=0.305, p=0.594, p=0.280, and p=0.922, respectively). About 36.7% (n=90) of the participants were found to be COVID-19 positive by PCR among which the non-vaccinated cases had higher rates of COVID-19 seropositivity than the vaccinated cases (40.6% vs 15.8%) (OR=3.6, 95%CI: 1.5-9.0, p=0.004). Conclusion: Based on these results, we cautiously predict that immunity produced by MMR vaccination boosters may provide some degree of protection against COVID-19 in the adult population.
Effects of a fixed-payment method on demand for imaging tests in a university hospital
(Oxford Univ Press, 2008) Inandi, Tacettin; Ozer, Cahit; Balcı, Ali; Karazincir, Sinem
Background In 2006, a new medical payment framework such as fixed-payment method was implemented in Turkey and then cancelled 5 months later. The aim of this study was to explore the effects of this payment method on the demand for imaging tests. Methods Data were obtained retrospectively from electronic medical records. The main outcome measures were the number of imaging tests, the payment per outpatient and the rate of negative results of imaging tests. Results The overall mean number of imaging tests per outpatient was 0.75 +/- 0.13. This value decreased significantly after implementation of the fixed-payment method, and then increased after its cancellation (P < 0.01). The overall mean payment per outpatient was $14.1 +/- 2.3. For patients with social security, there was a significant decrease in the mean payment after implementation of the new method, followed by an increase after its cancellation (P = 0.02); in contrast, no significant changes were observed in patients not covered by social security (P > 0.05). No significant differences were observed in the rate of negative results for imaging tests (P > 0.05). Conclusions The use of a fixed-payment method reduces the demand for imaging tests when there is a strong financial relationship between the hospital and its personnel.
Effects of a rehabilitation program for Parkinson's patients on reaction and movement time: an electromyographic study
(Cukurova Univ, Fac Medicine, 2022) Kizil, Nurhan; Ogut, Halil; Okuyucu, Esra; Guler, Hayal; Ozer, Cahit; Turhanoglu, Ayse Dicle
Purpose: The aim of the study was to investigate the effects of a rehabilitation program consisting of specific exercises for Parkinson's Disease (PD) patients on reaction time (RT), movement time (MT), quality of life and disease activity. Materials and Methods: A total of 26 idiopathic PD patients were included in the study. The exercises specific to Parkinson's were applied to the patients for 16 weeks. The evaluation of the patients were done before and after the treatment. The disease severity was measured with Unified Parkinson's Disease Rating Scale (UPDRS), quality of life was measured with Short Form-36 (SF-36). RT and MT measurements were done electromyographically. Results: There was no statistically significant difference in UPDRS total and sub-section values and SF-36 quality of life evaluation before and after the exercise program. While a significant decrease was observed in the RT values of the patients after the 16 week exercise program compared to prior to the program (Deltoid RT 370.46 +/- 25 to 219.58 +/- 17, biceps RT 370.42 +/- 27 to 216.49 +/- 14 and triceps RT 445.21 +/- 31 to 247.53 +/- 23, respectively). Conclusion: In PD, the rehabilitation program specific to the disease leads to a significant decrease in RT. Although the exercise has no statistically significant effect on disease activity, quality of life and MT values, it was seen that it still led to improvement.
The Effects of Elimination of Gate-Keeping on Tertiary Care and the Social Insurance System
(Galenos Publ House, 2011) Savas, Nazan; Ozer, Cahit; Inandi, Tacettin
The aim was to investigate the effects of elimination of gatekeeping on a university hospital and Social Insurance Institute (SII). Electronic records of 2006-2007 were analyzed. The mean outpatient visits was 273.8 +/- 69.9 before the gate-keeping elimination, it was 471.8 +/- 114.7 after the gate-keeping elimination (p<0.001). The increased rate of visits were in the department of cardiology (95.4%) followed by respiratory medicine (33.3%), orthopedics (22.6%), neurology (16.1%) and gynecology (11.4%). Also the most frequent diagnoses changed in these departments. The most frequent diagnoses before and after elimination were as follows; hypertension in comparison to anxiety disorders after elimination in cardiology, chronic obstructive lung disease compared to myalgia in respiratory medicine, fracture follow up compared to joint pain in orthopaedics, epilepsy compared to dizziness in neurology and infertility compared to vaginitis in gynecology. SII has paid 10.67 fold higher dues after elimination for these 7 departments and diagnoses. Consequently; elimination of the gate-keeping can easily be applied to tertiary care and can increase health expenditures.
Effects of season-induced hormonal changes on mortality
(Medi+World Int, 2012) Helvaci, Mehmet Rami; Ari, Mustafa; Maden, Emin; Aydin, Leyla Yilmaz; Aydin, Yusuf; Ozer, Cahit
Background: We tried to understand whether or not there are some seasonal differences in human mortality rates in the present study. Methods: The study was performed in the General Internal Medicine and Hematology Clinics between March 2007 and December 2010. All hospitalized cases in these units during the 45-month period were included into the study. The total number of deaths in each season were detected and compared. Results: There were 68 deaths during the period, with various causes. Although there were only three deaths in July, there were nine in October. In other words, the total number of deaths was the highest in autumn with 22 deaths (32.3% of all) in the 45-month period, totally. It was 13 (25.4%) in winter, 16 (23.5%) in spring, and 17 (25.0%) in the summer. Although there is obvious difference in the number of deaths between autumn and the other seasons, the difference was statistically nonsignificant probably due to the small number of death cases (p= 0.481). Conclusion: Although seasonal differences of human mortality rates were statistically nonsignificant, this was probably due to the small number of death cases of the present study; there may actually be a significant increase in autumn with unexplained reasons yet. Relative hormonal insufficiencies during the passage from a summer-like relaxed, to an autumn-like stressful season may be one of the causes. If so, it can be prevented by some hormonal replacement therapies, thus this theory should be searched with a higher number of cases in a more detailed approach.
Evaluation of hemoglobinopathy screening results of a six year period in Turkey
(Drunpp-Sarajevo, 2012) Arica, Secil Gunher; Turhan, Ebru; Ozer, Cahit; Arica, Vefik; Silfeler, Dilek Benk; Silfeler, Ibrahim; Altun, Ayse Betul
Background and Objectives: Hemoglobinopathies are autosomal recessive inherited diseases more commonly seen in Mediterranean countries. Hereditary blood diseases including Bthalassemia and sickle cell anemia are important health problems. In our study we aimed to analyze the results of the premarital hemoglobinopathy screening test for a 6 years period in Hatay region. Material and Methods: The study sample comprised the couples attending to the Mother and Child Health Care Center in Hatay for premarital hemoglobinopathy screening from 2004 to 2009. Hemoglobin chain analyses of 87.830 couples were evaluated. Results: 175.660 people were screened at total. The prevalence of beta thalassemia trait, sickle cell anemia trait, sickle cell anemia, beta thalassemia major, beta-thalassemia intermedia, alphathalassemia, alpha-thalassemia trait was found as 13.921 (7,9%), 6.074 (3,4%), 631 (0.35%), 132 (0.07%), 118 (0.06%), 9 (0.005%), 150 (0.08%) respectively. 72 newborns with betathalassemia were diagnosed as a result of the marriage of the carrier couples in 6 years. Conclusions: Hatay is a high risk region for beta-thalassemia and sickle cell anemia trait. In countries with high prevalence of hemoglobinopathies, a premarital screening program and counseling is needed to decrease the prevalence.
Evaluation of the mean platelet volume in children with familial Mediterranean fever
(Springer Heidelberg, 2012) Arica, Secil; Ozer, Cahit; Arica, Vefik; Karakus, Ali; Celik, Tanju; Gunesacar, Ramazan
To evaluate the Mean Platelet Volume (MPV) levels in children diagnosed with familial Mediterranean fever (FMF), during attack and attack-free periods. The records of a total of 117 children with FMF, diagnosed using the Tel-Hashomer criteria, have been scanned. The study consisted of 53 patients during an attack (group 1), 64 patients in attack-free period (group 2), and 57 healthy controls (group 3). Erythrocyte sedimentation rate, C-reactive protein, white blood cell count, platelet count, and MPV levels were retrospectively recorded. The MPV and platelet values in FMF patients during attack (group 1) and FMF patients during attack-free periods (group 2) have been found to be significantly higher than those of the health control group (group 3). Positive correlation has been found between the MPV and platelet values in Group 1 and the disease's severity score (r = 0.224, and r = 0.268, respectively). Positive correlation (r = 0.528, and r = 0.485, respectively) has been also identified between MPV and blood platelet count in patients in Group 1 and 2. No correlation was found between the Colchicine treatment period and MPV (r = -0.005). The MPV values in the complete group of FMF diagnosed children have been found to be much higher compared to those in healthy children. As a consequence, we consider the MPV value as a useful marker that demonstrates the risk of early stage atherosclerosis in children with FMF.
Hepatitis C virus infection is probably associated with autoimmune disorders and malignancies but not with autoimmune thyroiditis
(Asian Network for Scientific Information, 2007) Kuvandik, Guven; Helvaci, Mehmet Rami; Ozer, Cahit; Altintas, Engin; Kaya, Hasan; Duru, Mehmet
In this study initially consecutive patients with Autoimmune Thyroiditis (AT) were taken in the Endocrinology Polyclinics. Beside that age and sex-matched patients with HCV infection and control cases were randomly studied in the Gastroenterology and Internal Medicine Polyclinics, respectively. One hundred and seventy-two patients with AT, 62 with HCV infection and 110 control cases were studied. AT was diagnosed in eight (12.9%) cases of the HCV infecteds' group and this ratio was 11.8% (13 cases) in the control group (p>0.05). Similarly, HCV infection was detected in one (0.5%) case of AT group and this ratio was 0.9% (one case) in the control group (p>0.05). Parallel to these results, prevalences of antithyroid peroxidase and/or antithyroglobulin antibodies were detected as 29.0% (18 cases) and 32.7% (36 cases) in the HCV infecteds' and control groups, respectively (p>0.05). As another face of the results, it was detected one case of monoclonal gammopathy of undetermined significance and one case of lichen planus in the HCV infecteds' group. As a conclusion, HCV infection may be associated with autoimmune disorders and malignancies but not with AT.
Herbal supplement usage in cardiac patients
(Turkish Soc Cardiology, 2017) Pinar, Neslihan; Topaloglu, Meyli; Ozer, Cahit; Alp, Harun
Objective: Complementary and alternative medicine (CAM) has become more and more widespread around the world. CAM is a broad term that refers to all medical healthcare services, methods, and practices that are not part of standard medical care, as well as the accompanying theories and beliefs. The aim of the present study was to investigate the use of herbal medicinal products in cardiac patients, as well as the methods of administration of the products. Methods: This descriptive cross-sectional study included 199 patients aged over 18 years who were hospitalized in the Defne Hospital department of cardiology and volunteered to participate in a 20-item survey between April 2016 and June 2016. Results: The study results indicated that 28.6% (n=57) of the patients were using herbal medicinal products and 71.6% (n=142) said they did not. Only 14.03% (n=8) of those who used herbal medicinal products said they used them in consultation with their physician; 85.9% (n=49) had used herbal medicine without consulting their doctor. Of the participants with hypertension, 35.7% of them reported using herbal medicinal products. Of these, 22.5% of them were consuming lemon, 17.5% pomegranate syrup, and 17.5% green tea. Of the participants with cardio-vascular diseases, 23.5% of them stated that they were taking herbal medicinal products. Of these, 25% were consuming green tea, 25% ginger, and 18.8% sage. Conclusion: Herbal medicinal supplements were used by a large portion of the cardiac patients in this study. Furthermore, most of the patients stated that they were using these products without informing their physician, a practice that can have unwanted consequences.

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