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    Effects of ebselen on radiocontrast media-induced hepatotoxicity in rats
    (Sage Publications Inc, 2013) Basarslan, Fatmagul; Yilmaz, Nigar; Davarci, Isil; Akin, Mustafa; Ozgur, Mustafa; Yilmaz, Cahide; Ulutas, Kemal Turker
    Oxidative stress is accepted as a potential responsible mechanism in the pathogenesis of radiocontrast media (RCM)-induced hepatotoxicity. Therefore, we aimed to investigate the protective effects of ebselen against RCM-induced hepatotoxicity by measuring tissue oxidant/antioxidant parameters and histological changes in rats. Wistar albino rats were randomly separated into four groups consisting of eight rats per group. Normal saline was given to the rats in control group (group 1). RCM was given to the rats in group 2, and both RCM and ebselen were given to the rats in group 3. Only ebselen was given to the rats in group 4. Liver sections of the killed animals were analyzed to measure the levels of malondialdehyde (MDA) and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), as well as histopathological changes. In RCM group, SOD and CAT levels were found increased. In RCM-ebselen group, MDA, SOD and CAT levels were found decreased. In RCM-ebselen group, however, GSH-Px activities of liver tissue increased. All these results indicated that ebselen produced a protective mechanism against RCM-induced hepatotoxicity and took part in oxidative stress.
  • Küçük Resim
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    Spinal anesthesia for a rare case of Proteus syndrome
    (Aves Press Ltd, 2014) Ozgur, Mustafa; Ceylan, Fatma Bilge; Ozler, Serkan
    Our purpose is to present an uneventful spinal anesthesia experience in a rare case with Proteus syndrome (PS) suffering from urolithiasis. A 17-year-old male patient with previously diagnosed PS admitted to the urology polyclinic for urolithiasis. Physical examination showed disproportionate growth of the lower extremities, amputated toes and superficial and large veins in the legs. Spinal anesthesia was successfully administered at sitting position through the intrathecal route via the L3-4 space in the midline. Since it also includes difficult airways, spinal canal deformities, thromboembolisms, and certain pathologies such as cystic abnormalities in the lung, emphysema, atelectasis and fibrosis, this syndrome should be considered further with respect to anesthesia. The most significant cause of mortality in PS is pulmonary thromboembolism induced by deep vein thrombosis caused by growing extremities. Spinal anesthesia has provided a more reliable method of anesthesia due to the lower risk of development of thromboembolism in this case.