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Öğe Adenosquamous carcinoma of the pancreas: A case report(Springer, 2017) Dogan, E.; Gokce, A. Orhan; Secinti, I. E.; Gursoy, D.; Ozgur, T.; Hakverdi, S.; Dogan, U. B.[Abstract Not Available]Öğe Adrenocortical carcinoma: A case report(Springer, 2017) Gokce, A. Orhan; Dogan, E.; Gursoy, D.; Secinti, I. E.; Ozgur, T.; Hakverdi, S.; Gorur, S.[Abstract Not Available]Öğe AMACR and iNOS expressions in prostate adenocarcinomas(Springer, 2012) Ozgur, T.; Atik, E.; Hakverdi, S.; Yaldiz, M.[Abstract Not Available]Öğe Calvarial metastasis as clinic presentation of renal cell carcinoma: A case report(Springer, 2017) Ceylan, E. Cengiz; Dogan, E.; Secinti, I. E.; Gursoy, D.; Ozgur, T.; Hakverdi, S.; Yilmaz, A.[Abstract Not Available]Öğe Characterization of immunohistochemical markers in triple negative breast carcinomas(Imprimatur Publications, 2013) Atik, E.; Guray, M.; Ozgur, T.; Canda, T.Purpose: Triple negative (TN) breast carcinomas (estrogen receptor/ER, progesterone receptor/PR and HER-2/neu negative) constitute 15-25% of all breast carcinomas and have been correlated with aggressive behavior and poor prognosis. Our aim was to describe and characterize the immunophenotype of these tumors in a group of patients from Turkey. Methods: We used the immunohistochemical markers CK5/6, CK14, EGFR, E-cadherin, p53 and androgen receptor. Formalin-fixed, paraffin-embedded tissues from 51 breast carcinoma patients (36 TN and 15 non TN) were included into this study. Results: The mean values of the distribution of immunohistochemical markers in TN vs non-TN groups were as follows: CK5/6 78.4 vs 5.3%, CK14 84.8 vs 8%, EGFR 87.2 vs 8%, E-cadherin 96.9 vs 53.2%, p53 87.3 vs 7.3% and androgen receptor 89.5 vs 33.3% (all p-values<0.001). CK5/6 stained significantly different in the grade 2 and 3 cases (p=0.035) in the TN group. The other markers demonstrated no significant differences between grades. Conclusion: TN breast carcinomas in Turkish patients express basal cytokeratins, and have high levels of p53 compared to non-TN breast carcinomas.Öğe Characterization of immunohistochemical markers in triple negative breast carcinomas from Turkey(Springer, 2013) Dogan, E.; Guray, M.; Ozgur, T.; Canda, T.[Abstract Not Available]Öğe Congenital (infantile) fibrosarcoma of the scalp: A case report(Springer, 2017) Dogan, E.; Ceylan, E. Cengiz; Gursoy, D.; Secinti, I. E.; Hakverdi, S.; Ozgur, T.; Serarslan, Y.[Abstract Not Available]Öğe Cytological, histopathological and clinical correlation at differential diagnosis of granulomatous mastitis-malignancy(Springer, 2012) Ozgur, T.; Atik, E.; Toprak, S.; Gokce, H.; Sengul, N.; Temiz, M.[Abstract Not Available]Öğe Dermoid cyst: A rare entity of the parotid gland(Springer, 2013) Toprak, S.; Ozgur, T.; Gokce, H.; Cevik, C.; Akbay, E.; Atik, E.[Abstract Not Available]Öğe Diffuse osteosclerosis in a patient with prostate cancer(Springer London Ltd, 2014) Ustun, N.; Ustun, I.; Ozgur, T.; Atci, N.; Aydogan, F.; Sumbul, A. T.; Turhanoglu, A. D.A 61-year-old man was referred to our outpatient clinic because of severe bilateral upper leg pain for 1 year. On admission, the patient had anemia and a high serum alkaline phosphatase level. Lumbar and femoral neck T-scores were +10.5 and +9.6, respectively. His radius 33 % T-score was -2.8. Plain radiographs of the patient's pelvis, spine, and long bones revealed osteosclerosis. The patient had previously undergone a prostate biopsy, which showed prostate adenocarcinoma (Gleason score 3 + 4). The patient's total and free prostate-specific antigen were very high. According to previous records, the patient did not have anemia, and his serum alkaline phosphatase (ALP) level was normal. An abdominal radiograph taken 2 years earlier revealed a normal spine and pelvic bone. Bone scintigraphy yielded nontypical findings for prostate cancer metastasis. Computed tomography of the patient's thorax and abdomen showed heterogeneous sclerotic areas in all bones consistent with prostate cancer metastasis. A bone marrow biopsy disclosed disseminated carcinomatosis of bone marrow in association with prostate cancer. Clinicians should be aware of the possibility of prostate malignancy as a cause of high bone mineral density (BMD), even in the absence of typical localized findings on plain radiographs.Öğe The effects of mobile phones on apoptosis in cerebral tissue: an experimental study on rats(Verduci Publisher, 2014) Yilmaz, A.; Yilmaz, N.; Serarslan, Y.; Aras, M.; Altas, M.; Ozgur, T.; Sefil, F.INTRODUCTION: The concern about mobile phone effects is increasing as the number of users increasing too. Different studies have different results, so this topic is still open to discussion. Aim of this report was to investigate the effects of the mobile phones on the Bcl-2 gene and p53 proteins in rat brains. MATERIALS AND METHODS: In the study group of 10 rats; mobile phones that spread EMW at a frequency between 1900-2100 MHz and Specific Absorption Rate range between 0.005 W/kg and 0.288 W/kg (Dialing mode), 0.004 W/kg and 0.029 W/kg (Calling mode) were attached to rat ears for simulating usage in daily life for 7 times a day during 5 minutes (3 seconds dialing mode, 4 minutes and 47 seconds of calling mode) for a four week period. Sham group (n=10) rats were only immobilized without EMW exposure. Another group of rats (n=10) were counted as control without any application. immunohistopathological examination was performed for p53 and Bcl-2 expression. RESULTS: Immunohistopathological examinations revealed that the samples in the study group had more p53 and Bcl-2 positive stained cells and they were stained denser. In both evaluations, these differences between the study and control group were found statistically significant (p < 0.003); In Bcl-2 evaluation statistically significant difference was found between study and sham group to (p < 0.005); however, the p53 evaluation between the study and the sham group did not show any statistically significant difference (p > 0.005). CONCLUSIONS: Our results showed that the electro-magnetic waves emitted by the mobile phones may have effect on apoptosis. Besides, obtained data revealed that more realistic application of mobile phones during experiments is more important as expected.Öğe Effects of montelukast and methylprednisolone on experimental spinal cord injury in rats(Verduci Publisher, 2014) Cavus, G.; Altas, M.; Aras, M.; Ozgur, T.; Serarslan, Y.; Yilmaz, N.; Sefil, F.OBJECTIVE: The development of secondary brain injury after trauma is known to involve in many cellular mediators. The aim of the study was to evaluate and compare the effects of the use of both methylprednisolone and montelukast on serum and tissue concentrations of NO, malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity, and tissue glutathione peroxidase (GSH-Px) activity in rats with spinal cord injury (SCI). MATERIALS AND METHODS: SCI was induced in Wistar albino rats by dropping a 10 g rod from a 5.0 cm height at T9-10. The 28 rats were randomly divided into four equal groups: montelukast, methylprednisolone, non-treatment and sham groups. Rats were neurologically tested at 24 hours after trauma and spinal cord tissue levels of MDA, SOD, GSH-PX, CAT levels and blood CK, CK-BB, LDH levels were measured. In addition, histopathological changes were also examined. RESULTS: There was a significant improvement in Tarlov scores in methylprednisolone and montelukast administered group compared to the trauma group (p = 0.001). When compared to trauma group, methylprednisolone and montelukast groups had significant differences in MDA (p < 0.05), SOD (p < 0.001), CK-BB (p < 0.001) and LDH (p < 0.05) levels. Histopathologically, no significant changes were observed. CONCLUSIONS: The present study shows effects of montelukast with biochemical and histopathological parameters and compares its effects with those of methylprednisolone for the first time. Our research has shown that montelukast and methylprednisolone have a neuroprotective effect on spinal cord injury.Öğe Epidermoid cyst in tongue: A case report(Springer, 2017) Gokce, A. Orhan; Dogan, E.; Secinti, I. E.; Gursoy, D.; Hakverdi, S.; Ozgur, T.; Ozkan, M.[Abstract Not Available]Öğe An evaluation of brain tumour cases among Syrian refugees in Hatay, Turkey(Springer, 2017) Hakverdi, S.; Secinti, I. E.; Gursoy, D.; Ozgur, T.; Serarslan, Y.; Dogan, E.[Abstract Not Available]Öğe Extraskeletal osteosarcoma located in abdominal wall: A case report(Springer, 2017) Dogan, E.; Gokce, A. Orhan; Gursoy, D.; Secinti, I. E.; Hakverdi, S.; Ozgur, T.; Temiz, M.[Abstract Not Available]Öğe Gemistocytic astrocytoma with granulomatous inflammation(Springer, 2012) Ipci, O.; Dogan, E. Atik; Ozgur, T.; Gokce, H.; Yilmaz, N.; Yilmaz, A.[Abstract Not Available]Öğe Immunohistochemical analysis of thyroid follicular neoplasms and BRAF mutation correlation(Indian Cancer Soc, 2014) Atik, E.; Guray, M.; Gunesacar, R.; Ozgur, T.; Canda, T.Background: The accurate diagnosis of benign and malign thyroid tumors is very important for the clinical management of patients. The distinction of thyroid papillary carcinoma follicular variant and follicular adenoma can be difficult. Aim: To investigate the alternative methods like immunohistochemistry and exon 15 in the BRAF gene 1799 T/A mutation analyses for distinguishing thyroid tumors. Materials and Methods: We applied immunohistochemical markers; CK19, HMWCK, Galectin-3, HBME-1 and Fibronectin and mutant allele-specific PCR amplification technique was used to determine 1799 T/A mutation within the BRAF gene. Formalin-fixed parafin embedded tissues from 45 surgically total resected thyroids, included 26 thyroid papillary carcinoma follicular variant (FV-TPC), 8 Follicular Adenoma (FA), 6 Minimal invasive follicular carcinoma (MIFC) and 5 Follicular Carcinoma (FC). Statistical Analyses Used: Pearson Chi-Square and Kruskal Wallis tests were performed. Results: There was a positive correlation between FV-TPC and HMWCK, CK 19, HBME1, Galectin 3, fibronectin (P < 0.05), but there was no correlation with FV-TPC and BRAF gene mutation (P > 0.05). HBME-1 and CK 19 stained strong and diffuse positive in FV-TPCs but weak and focal in FAs. Conclusion: Our study suggests that morphologic features combined with immunohistochemical panel of HMWCK, CK19, HBME-1, Galectin-3 and fibronectin can help to distinguish benign and malign thyroid neoplasms and FV-TPC from follicular adenomas. BRAF gene 1799 T/A mutation has been non-specific but its detection can be a useful tool combined with immunohistochemistry for diagnosing FV-TPC.Öğe Immunohistochemical detection of p53 and MDM2 expressions in liposarcoma with World health organization classification(Wolters Kluwer Medknow Publications, 2013) Arici, A.; Ozgur, T.; Ugras, N.; Yalcinkaya, U.Background: Liposarcomas are among the most common soft tissue sarcomas in adulthood. Aim: The purpose of the study is to perform a histopathologic typing according to World Health Organization (WHO) classification of cases diagnosed with liposarcoma and to examine the difference of p53 and MDM2 expressions. Materials and Methods: The haematoxylin-eosin stained sections of 48 subjects enrolled in the study have been evaluated on the basis of the WHO classification for liposarcoma and sections stained using p53 and MDM2. Statistical Analysis Used: Chi-Square test was applied. Results: 20 subjects were diagnosed with well-differentiated liposarcoma (WLS), 16 myxoid liposarcoma (ML), 7 pleomorphic liposarcoma (PL), and 5 de-differentiated liposarcoma (DLS). The number of cases stained positive with MDM2 and p53 were positive correlated in all subjects (P = 0.02). p53 and MDM2 positivity increased in high grade tumors (P = 0.01). Conclusion: p53 and MDM2 immuno-reactivity was found to be potentially useful in liposarcoma diagnosis but a definitive implication would be rather unhealthy due to the small number of cases in our study.Öğe Immunohistochemical seperation of thyroid papillary carcinoma follicular variant from follicular adenoma and RET/PTC correlation(Springer, 2012) Ozgur, T.; Atik, E.; Guray, M.; Gunesacar, R.; Canda, T.[Abstract Not Available]Öğe Intracranial benign cystic lesions(Springer, 2017) Secinti, I. E.; Hakverdi, S.; Gursoy, D.; Ozgur, T.; Dogan, E.; Serarslan, Y.[Abstract Not Available]
