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Öğe Diagnostic Value of MRCP in Biliary Pancreatitis: Result of Long-Term Follow-up(Taylor & Francis Ltd, 2012) Okan, I.; Bas, G.; Sahin, M.; Alimoglu, O.; Eryilmaz, R.; Ozkan, O. V.; Hasiloglu, Z. I.Aim : Magnetic resonance cholangiopancreatography (MRCP) has increasingly been used to evaluate the common bile duct. This study was to determine the role of MRCP instead of endoscopic retrograde cholangiopancreatography (ERCP) in the management of patients with acute biliary pancreatitis. Methods : A total of 81 patients with mild or moderate biliary pancreatitis who underwent MRCP and were treated in our department with selective ERCP between May 2001 and July 2007 were entered into a prospective database. Results : MRCP was considered abnormal in 13 patients. Ten patients underwent ERCP. Three patients did not undergo ERCP due to protocol violations. In nine patients, stone extraction was performed. The remaining patient who had dilatation of the CBD underwent ES. The false positive rate of MRCP was 10%. The median follow-up of overall patients was 36 months (range 23-99 months). The patients with normal MRCP had a median follow-up of 39.5 months (range 23-99 months). During the follow-up period in the normal MRCP group, five patients were diagnosed with recurrent biliary pancreatitis, of which three underwent ERCP (7.4%). There was no disease-related mortality during this period. Conclusion : In conclusion, the use of MRCP in acute biliary pancreatitis is safe and may be recommended as a tool to aid in the selective use of ERCP.Öğe Effect of Gentamicin-absorbed Collagen in Wound Healing in Pilonidal Sinus Surgery: a Prospective Randomized Study(Sage Publications Ltd, 2010) Yetim, I.; Ozkan, O. V.; Dervisoglu, A.; Erzurumlu, K.; Canbolant, E.Pilonidal sinus is a common disease that causes the loss of many working hours, but treatment is variable and problematic. The effect of gentamicin-absorbed collagen on healing, infection and recurrence, and length of hospital stay were examined after pilonidal sinus surgery. Patients undergoing surgical treatment for pilonidal sinus were randomly assigned into two groups each of 40 patients. Both groups were treated with excision and primary closure under local anaesthesia. Group 1 (control) received oral antibiotics for 7 days post-operatively. In group 2, prior to wound closure, gentamicin-absorbed collagen sponges were placed on the sacral fascia and these patients did not receive oral post-operative antibiotic therapy. Patients in group 2 had a significantly shorter mean wound healing time, significantly lower infection and recurrence rates, and a significantly shorter hospital stay than those in group 1. It is concluded that implantation of a gentamicin-containing collagen sponge on the wound area in pilonidal sinus decreased the rates of infection and recurrence, and shortened the hospital stay.Öğe Effect of Local Gentamicin Application on Healing and Wound Infection in Patients with Modified Radical Mastectomy: a Prospective Randomized Study(Sage Publications Ltd, 2010) Yetim, I.; Ozkan, O. V.; Dervisoglu, A.; Erzurumlu, K.; Canbolant, E.This study investigated the effects of Gentacoll implants on healing in patients (n = 44) undergoing modified radical mastectomy and axillary dissection. Group I, the Gentacoll group (n = 22), underwent surgery followed by insertion of 10 x 10 x 0.5 cm Gentacoll implants (280 mg collagen sponge plus 200 mg gentamicin sulphate) into the axillary area and under the flap area of the breast before wound closure. Group II, the control group (n = 22), underwent surgery without the application of Gentacoll. Neither group received oral or parenteral post-operative antibiotic therapy. Outcome measures included wound infection, seroma formation, total drainage volumes, drain removal time and duration of hospital stay. Postoperative infection rate, seroma formation, drainage volumes and duration of hospital stay were significantly reduced in the Gentacoll group compared with the control group. In conclusion, the application of Gentacoll significantly improved postoperative outcomes in patients undergoing modified radical mastectomy.Öğe For how many times can a partially absorbable monofilament mesh be sterilized? In vitro experimental study(Springer Wien, 2013) Ozkan, O. V.; Aydogan, A.; Akkucuk, S.; Aydin, M.; Nacar, E.; Ozer, B.; Mistikoglu, S.We investigated the effects of hydrogen peroxide gas plasma resterilization (HPS) on partially absorbable monofilament meshes in terms of their mechanical properties and risk of infection. A mesh was divided into small pieces which were categorized as HPS-1, HPS-2 and HPS-3 according to the number of HPS. To assess the strength of specimens, maximum load, elongation at maximum load and quantity of energy required for complete failure of the specimens were measured. Microbiological and ultrastructural analyses were also performed. There was not a significant relationship between control and HPS-1, HPS-2 groups in terms of maximum load and quantity of energy required for complete failure of the specimens. However, those parameters were statistically different between HPS-3 and control groups. We observed minor morphological changes in the HPS-3 group when compared to those of the control group. No risk of infection was detected by microbiological tests. It is advisable to apply HPS to partially absorbable monofilament meshes no more than twice since sterilization for three times leads to degeneration in mesh structure and strength.Öğe Is There any Significant Association Between Irritable Bowel Syndrome and Cholelithiasis ?(Aves, 2008) Kuvandik, G.; Helvaci, M. R.; Ozkan, O. V.; Sogut, S.; Kaya, H.; Bozkurt, S.Background: We tried to understand whether or not there is a significant etiopathogenetic relationship between irritable bowel syndrome (IBS) and cholelithiasis. Methods: Consecutive patients with upper abdominal discomfort were included into the study. Routine hematologic and biochemical tests, an abdominal ultrasonography, and a questionnaire for IBS was performed in all cases, and IBS is diagnosed according to Rome II criteria in the absence of red flag symptoms. Cholelithiasis cases were put into one group and age and sex-matched and randomly selected cases without cholelithiasis were put into the other group. Prevalences of smoking, normal weight, overweight, obesity, and IBS were detected in each group and compared in between. Results: One hundred and twenty-one patients with cholelithiasis were diagnosed. Ninety-seven (80.1%) of them were female, and their mean age was 53.4 +/- 9.9 (27-70) years. Interestingly, 92.5% (112 cases) of the cholelithiasis cases had excess weight and obesity was significantly higher in the cholelithiasis group (54.5% vs. 43.8%, p<0.05). Prevalence of IBS was nearly equal in both groups (43.8% in cholelithiasis vs. 42.1% in control cases, p>0.05). Conclusions: IBS probably is a cascade of many physiological events, being initiated with infection, inflammation, psychological disturbances-like stresses and eventually terminated with dysfunctions of genitourinary tract and probably some other systems of body via a low-grade inflammatory process. Although IBS probably has a much more complex mechanism than the current view and a higher prevalence in society, there is not a significant association between IBS and cholelithiasis.Öğe Protective effect of caffeic acid phenethyl ester on cyclosporine A-induced nephrotoxicity in rats(Elsevier Science Bv, 2009) Gokce, A.; Oktar, S.; Aydin, M.; Ilhan, S.; Yonden, Z.; Ozkan, O. V.; Davarci, M.[Abstract Not Available]Öğe The Relationship between Mortality and Inflammation in Patients with Gastrointestinal Bleeding(Sage Publications Ltd, 2009) Koseoglu, Z.; Ozkan, O. V.; Semerci, E.; Aslan, A.; Yetim, I.; Ucar, E.; Kuvandik, G.The objective of this study was to investigate the association between mortality and inflammation in patients who were admitted to the emergency room with gastrointestinal bleeding. Patients (n = 96) managed at two medical centres were included in the study. Initial levels of serum C-reactive protein (CRP), haemoglobin and albumin, and leucocyte and thrombocyte counts for 28 patients who died were compared with those for the 68 patients who survived and were successfully discharged. The data were analysed using the chi(2)-test. Serum levels of CRP and leucocyte counts were significantly higher, and albumin and haemoglobin were significantly lower in patients who died compared with patients who survived. The increased levels of serum CRP and leucocyte counts, and decreased levels of albumin and haemoglobin were found to be independent risk factors for mortality. It is concluded that increased serum CRP levels and leucocyte counts combined with decreased albumin and haemoglobin levels on admission to the emergency room may be used as predictive factors of mortality in patients with gastrointestinal bleeding.
