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  • Küçük Resim
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    Congenital cervical teratomas: clinical approach
    (Galenos Yayincilik, 2008) Atabek, C.; Surer, I.; Caliskan, B.; Temiz, A.; Demirbag, S.; Ozturk, H.
    Congenital cervical teratomas are rare, representing 3% of teratomas in childhood. Although mostly benign, they are associated with a high mortality rate due to respiratory distress and require immediate surgical excision. If not promptly managed with surgical resection, the mortality rate of cervical teratomas, is very high and reaches to 80-100%. In recent years, congenital cervical teratomas are frequently diagnosed on the antenatal sonogram and delivered in elective conditions. The first step in postnatal period is usually immediate endotracheal intubation due to respiratory distress. The diagnosis is usually suggested on the physical examination. The imaging investigation is essential for the proper diagnosis and preoperative planning. The most suitable treatment in cervical teratomas is surgical totally excision of the mass. In this paper we discussed congenital cervical teratomas with two cases.
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    N-Acetylcysteine prevents doxorubucine-induced cardiotoxicity in rats
    (Sage Publications Ltd, 2013) Arica, V.; Demir, I. H.; Tutanc, M.; Basarslan, F.; Arica, S.; Karcioglu, M.; Ozturk, H.
    This study is designed to observe the effects of N-acetylcysteine (NAC) on doxorubucine-induced cardiac toxicity in rats both histologically and biochemically. Totally 32 rats divided equally into four groups were studied. The first group received only 200 mg/kg NAC intraperitoneal (i.p.) once every 24 h for 5 days (group 1); the second group received 20 mg/kg doxorubucine (DOX) i.p. single dose plus NAC 200 mg/kg i.p. once every 24 h for 5 days (group 2); the third group received DOX 20 mg/kg DOX i.p. single dose (group 3) and the fourth group, which is also the control group, received saline (group 4). Following 24 h of the final dose, blood samples were drawn from a portal vein and heart tissue were obtained. Tissue thiobarbituric acid reactive substance (TBARS) and nitric oxide (NO) levels were highest in the DOX group. In the DOX-treated rats, serum TBARS, NO, aspartate transaminase, lactate dehydrogenase and creatine kinase levels were highest when compared with other groups. Except for serum superoxide dismutase levels, all other parameters differed significantly between the DOX plus NAC group and the DOX group. In the DOX plus NAC group, general architecture was preserved better than the DOX group and myofibril loss was minimal compared with the DOX group. NAC demonstrated, both biochemically and histologically, to be effective in the prevention of DOX-induced cardiotoxicity in rat models. Evaluation of NAC's effect on DOX toxicity warrants further clinical trials on cancer patients.
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    Öğe
    A preliminary account of the presence of pear decline in Marmara region of Turkey
    (Int Soc Horticultural Science, 2008) Caglayan, K.; Serce, C. Ulubas; Gazel, M.; Ozturk, H.; Gencer, N. S.
    Severe decline of pear trees cv. Deveci growing in Turkey has reached recently striking levels. Initial symptoms of affected trees were observed as reddening in autumn and sometimes quick decline in a few days. All the orchards exhibiting quick decline symptoms had severe attacks of pear psyllids (Cacopysilla spp). In the early autumn of 2005, six leaf samples, showing a diverse range of symptoms and 40 pear psyllids, collected from symptomatic pear trees by using an insect net, were tested by polymerase chain reaction/restriction fragment length polymorphism analyses (PCR/RFLP). Universal phytoplasma primers P1/P7 and R16F2n/R2 were used for direct and nested PCR assays, respectively. Nested-PCR products were digested with RsaI, SspI and MseI restriction enzymes. After digestion with restriction enzymes the digested products showed the same profiles as the pear decline (PD) reference phytoplasma restriction profiles. PCR and RFLP tests of pear samples collected from the commercial orchards of Bursa province indicated PD infection of local cv. Deveci pear trees as well as the presence of PD phytoplasmas in pear psyllids.