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  • Küçük Resim
    Öğe
    Antioxidant effect of erdosteine and lipoic acid in ovarian ischemia-reperfusion injury
    (Elsevier Science Bv, 2014) Dokuyucu, Recep; Karateke, A.; Gokce, H.; Kurt, R. K.; Ozcan, O.; Ozturk, S.; Tas, Z. A.
    Objective: To investigate the effects of erdosteine and alpha lipoic acid (ALA) in a rat model of ovarian ischaemia-reperfusion injury. Study design: Forty-eight female Wistar albino rats were separated, at random, into six groups of eight rats. The groups were classified as: sham, torsion, detorsion, detorsion + erdosteine 100 mg/kg, detorsion + alpha lipoic acid (ALA) 100 mg/kg, and detorsion + erdosteine + ALA. The investigators executing the biochemical and histological analyses were blinded to the randomization until the end of the study. Results: The TOS (Total Oxidant Status) and OSI (Oxidative Stress Index) levels are higher in the Torsion and Detorsion groups when compared with the ones in the Sham group (p < 0.05). Strong correlation was found between OSI and total histological score in the sham, torsion and detorsion groups (r = 0.765, p < 0.001). The mean levels of TOS and OSI in the rats that received erdosteine and/or ALA were significantly lower compared with the sham, torsion and detorsion groups (p < 0.05). Mean TOS and mean OSI were lower in the detorsion + erdosteine + ALA group compared with the detorsion + erdosteine and detorsion + ALA groups (p < 0.05). In comparison with the detorsion group, the numbers of primordial follicles (p = 0.006) and primary follicles (p = 0.036) were increased in the groups that received erdosteine and/or ALA. Conclusions: Erdosteine and ALA decreased ischaemia-reperfusion injury in an experimental rat ovarian torsion model; combination treatment had a greater effect than either agent alone. Treatment with erdosteine and/or ALA was found to preserve the loss of reproductive capacity normally observed after ovarian torsion. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
  • Küçük Resim
    Öğe
    Effects of some heavy metals on thiol compounds in Synechocystis sp. isolates
    (Springer, 2020) Yilmaz, E. S.; Ozturk, S.; Aslim, B.
    The study aims to investigate the role of protein-bound, nonprotein and total thiols in metal resistance of Synechocystis isolates exposed to Ni(II), Cr(IV) and Pb(II). Synechocystis sp. BASO403 and BASO404 were investigated with regard to their exposure to 15 ppm Ni(II), 5 ppm Cr(VI) and 100 ppm Pb(II) for metal toxicity and thiol production. Each isolate was effected by metals when compared with controls. Also the role of protein-bound, nonprotein and total thiols in metal resistance of Synechocystis sp. isolates exposed to Ni(II), Cr(IV) and Pb(II) was determined. Synechocystis sp. BASO403 and BASO404 exposed to Cr(VI) produce higher protein-bound thiols when compared with control. In the present study, results showed that thiols might play a role in metal resistance by two Synechocystis sp. isolates.