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Öğe Corynebacterium pseudotuberculosis infection in Saanen x Kilis crossbred (White) goats in Ankara, Turkey and effective kanamycin treatment(Elsevier Science Bv, 2008) Ural, K.; Alic, D.; Haydardedeoglu, A. E.; Cedden, F.; Guzel, M.; Ozyildiz, Z.; Cantekin, Z.In the present paper we describe Corynebacterium pseudotuberculosis infection in the Saanen x Kilis crossbred goats with abscesses located in retropharyngeal (n=29), mandibular (n=49), parotid (n=26), superficial cervical (n=40), subiliac (n=23) and popliteal (n=11) lymph nodes. The most prominent site of the abscesses was in the anterior half of the body affecting 80.89% of the goats. Histopathological examination of the lymph nodes showed pyogranulomatous inflammation. The goats were randomly assigned to either kanamycin treatment group or a placebo. The efficacy of kanamycin was assessed clinically and on the basis of a lesion score derived from the examination of the affected lymph nodes. Clinical evaluations and lesion scoring were done by the same veterinary investigator. Both owners and the veterinary investigator were blinded to the allocation to the groups. Throughout the study kanamycin treatment significantly decreased (P < 0.05) the investigator's clinical scores while no significant changes were detected in the placebo group. (c) 2008 Elsevier B.V. All rights reserved.Öğe Evaluation of the age related changes in dog brains(Ecole Nationale Veterinaire Toulouse, 2010) Haziroglu, R.; Guvenc, T.; Tunca, R.; Ozsoy, S. Y.; Ozyildiz, Z.In this study it was aimed to compare the pathological findings on the brains of aged and young dogs. The research material consisted the brains of 20 dogs over 10 years old and brains of 10 dogs with an age of 1-2 years old. The brains were first of all examined macroscopically afterwards the tissue samples were taken from telencephalon, mesencephalon, rhombencephalon for histopathological and immunohistochemical investigations. In the aged dogs brains macroscopic examinations revealed meningeal thickness and ventricular dilatation. Microscopically, fibrosis at choroid plexus, meninges and vascular walls also ependymal defects, gliosis and neuronal depletion were observed in the aged dogs brains. On semi quantitative examination of the sections, a statistically significant increase on Glial Fibrillary Acidic Protein (GFAP) and 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNPase) expressions were determined in old dogs compared to young dogs (P<0.01).Öğe Immunohistochemical characterization of perineal melanoma in Kilis goats(2012) Ozyildiz, Z.; Ceylan, C.; Yilmaz, R.; Ozsoy, S.Y.We describe the clinical, histopathological and immunohistochemical features of the malignant melanomas in the perineal regions of Kilis goats from Sanliurfa province in Turkey. We studied 13 female Kilis goats between 3 and 8 years old that were brought to Harran University Veterinary School, Department of Surgery, between 2002 and 2010. By macroscopic examination, the masses were determined to have elastic consistency, dark brown-black color, necrotic surfaces and ulceration. Microscopically, pleomorphic cells were observed under the basal layer and these advanced toward the dermis. These cells were polyhedral, round or spindle-shaped, anaplastic, and their cytoplasm contained varying amounts of dark brown-black pigments. Immunohistochemical staining was obtained with anti-melan A, vimentin and S100 antibodies. © 2012 The Biological Stain Commission.Öğe Protective effect of L-carnitine on experimental lead toxicity in rats: a clinical, histopathological and immunohistochemical study(Taylor & Francis Ltd, 2011) Ozsoy, S. Y.; Ozsoy, B.; Ozyildiz, Z.; Aytekin, I.Female Wistar-albino rats were given lead acetate (PbAc) for 60 days to investigate the protective effects of L-carnitine (CA) clinically and histopathologically on PbAc-induced tissue damage. Blood samples were obtained from the jugular vein for hemoglobin (HB), hematocrit (HCT), red blood cells (RBC), white blood cells (WBC), platelets (PLT), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatinine. PbAc treatment caused a significant decrease in HB, HCT and RBC, a significant increase in WBC, AST, ALT and creatinine compared to controls. Although administration of CA did not reverse HB and HCT values, it reversed both the decrease in RBC and the increase in WBC, AST, ALT and creatinine. After the experimental period, all rats were weighed, then decapitated for pathological examination. Control rat liver, kidney and brain showed normal histological architecture. Lead-induced nephropathic kidneys; degenerative changes, inflammation and portal edema of the liver; and brain neuropil vacuolation, neuronal vacuolation, satellitosis and neuronophagia were observed in experimental groups. All changes were reduced in the PbAc group treated with CA (PbAc + CA). PbAc caused copper/zinc superoxide dismutase (Cu/Zn-SOD) expression in both the hepatocytes and tubular epithelium of the kidney. PbAc + CA exposure caused moderate Cu/Zn-SOD immunoreactivity. While in the brain sections of the PbAc group the degenerative neurons were stained intensely with anti-ubiquitin antibody, PbAc + CA rats showed moderate staining in neurons with anti-ubiquitin antibody. These results show that CA as a food additive reduced the severity of tissue damage caused by PbAc.
