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    COMPARISON OF ANTIBIOTIC RESISTANCE OF ACINETOBACTER AND PSEUDOMONAS AERUGINOSA STRAINS ISOLATED FROM INTENSIVE CARE UNITS WITH OTHER CLINICS
    (Carbone Editore, 2016) Ozer, Burcin; Inci, Melek; Duran, Nizami; Kurtgoz, Seyda; Alagoz, Gulcan; Pasa, Ozgur; Kilinc, Cetin
    Introduction: Acinetobacter and Pseudomonas strains lead to serious and nosocomial infections in intensive care units (ICUs) and the other clinics. Resistance of these bacteria against to antibiotics, in particular is emerging as a very significant in intensive care units. The factors which affect the increase in resistance to antimicrobial drugs are the high probability of encountering antimicrobial resistant microorganisms and empiric antimicrobial treatment. Materials and methods: The bacterial culture results of clinical specimens sent to Microbiology Laboratory of Mustafa Kemal University Hospital in five year period were examined retrospectively. Antimicrobial susceptibility of the bacteria of genus Acinetobacter and Pseudomonas aeruginosa isolated from these specimens were analyzed. The antibiotic resistance of P. aeruginosa and Acinetobacter strains isolated from ICUs and those isolated from other clinics was compared. Results: In five-year period, 772 P. aeruginosa and 971 Acinetobacter spp. were isolated from the specimens. Twenty-three percent of P. aeruginosa strains and 49.3% of Acinetobacter spp. were isolated from the patients in intensive care units. 628 (64.7%) of Acinetobacter and 92 (11.9%) of P. aeruginosa strains were found to be Multidrug Resistant (MDR). The ratios of multidrug-resistance in Acinetobacter strains isolated from the patients in ICUs were found to be higher than those in P. aeruginosa strains isolated from the patients in intensive care units. MDR ratio of these bacteria isolated in ICUs was higher than that isolated in the other clinics. Conclusion: Acinetobacter strains isolated from the patients in ICUs were determined to be more resistant than those isolated from the patients in other clinics while Pseudomonas strains isolated from the other clinics, were more resistant than those isolated from the patients hospitalized in ICUs. The ratio of MDR bacteria was higher in ICUs than that in other clinics.
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    Comparison of antibiotic resistance of acinetobacter and pseudomonas aeruginosa strains isolated from intensive care units with other clinics
    (A. CARBONE Editore, 2016) Ozer, Burcin; Inci, Melek; Duran, Nizami; Kurtgoz, Seyda; Alagoz, Gulcan; Pasa, Ozgur; Kilinc, Cetin
    Introduction: Acinetobacter and Pseudomonas strains lead to serious and nosocomial infections in intensive care units (ICUs) and the other clinics. Resistance of these bacteria against to antibiotics, in particular is emerging as a very significant in intensive care units. The factors which affect the increase in resistance to antimicrobial drugs are the high probability of encountering antimicrobial resistant microorganisms and empiric antimicrobial treatment. Materials and methods: The bacterial culture results of clinical specimens sent to Microbiology Laboratory of Mustafa Kemal University Hospital in five year period were examined retrospectively. Antimicrobial susceptibility of the bacteria of genus Acinetobacter and Pseudomonas aeruginosa isolated from these specimens were analyzed. The antibiotic resistance of P. aeruginosa and Acinetobacter strains isolated from ICUs and those isolated from other clinics was compared. Results: In five-year period, 772 P. aeruginosa and 971 Acinetobacter spp. were isolated from the specimens. Twenty-three percent of P. aeruginosa strains and 49.3% of Acinetobacter spp. were isolated from the patients in intensive care units. 628 (64.7%) of Acinetobacter and 92 (11.9%) of P. aeruginosa strains were found to be Multidrug Resistant (MDR). The ratios of multidrug-resistance in Acinetobacter strains isolated from the patients in ICUs were found to be higher than those in P. aeruginosa strains isolated from the patients in intensive care units. MDR ratio of these bacteria isolated in ICUs was higher than that isolated in the other clinics. Conclusion: Acinetobacter strains isolated from the patients in ICUs were determined to be more resistant than those isolated from the patients in other clinics while Pseudomonas strains isolated from the other clinics, were more resistant than those isolated from the patients hospitalized in ICUs. The ratio of MDR bacteria was higher in ICUs than that in other clinics.
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    Frequency, Distribution and Genotyping of Malassezia Species in Patients with Psoriasis vulgaris
    (Univ Press, 2021) Celik, Ebru; Duran, Nizami; Balci, Didem Didar; Dogramaci, Asena Cigdem; Pasa, Ozgur
    Background: Malassezia species are reported to play a role in the etiology of Psoriasis vulgaris. Objective: The aim of this study was to determine the presence, frequency, distribution, and genotyping of skin colonization of Malassezia species in Psoriasis vulgaris and to compare with healthy individuals and to investigate its relationship with the severity of the disease. Methods: Skin samples were taken from scalp, arm, body, and leg of 34 psoriasis patients (lesional/ non-lesional skin) and 30 healthy volunteers. Overall, 392 skin scraping samples were taken for the isolation of Malassezia species, which were incubated on the modified-Dixon agar. Conventional culture methods were used for Malassezia species identification. In isolates, genotyping was carried out by PCR-RFLP method. Results: In the samples from psoriatic lesions, most frequently isolated Malassezia species were M.globosa and M.furfur. Similarly, the most frequently isolated species in healthy volunteers was M. globosa; followed by M.restricta and M.sympodialis. The M.furfur isolation rate in psoriatic scalp and leg lesions of the patients was significantly higher than in healthy volunteers. There was no relationship between the severity of the disease and the isolated species. Conclusion: It was found that there was a difference between patients with psoriasis and healthy controls regarding presence and frequency of Malassezia species. Therefore, our study results support the view that Malessezia species may be associated with the etiopathogenesis of psoriasis. In addition, we surmise that the treatment applications for the regulation of skin microbiota of psoriasis patients will contribute positively to the treatment of psoriasis.
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    Virulence Factors in Staphylococci Isolated From Nasal Cavities of Footballers
    (Elsevier Science Inc, 2016) Duran, Nizami; Yildirim, Yunus; Duran, Gulay Gulbol; Pasa, Ozgur; Kilinc, Cetin; Yildirim, Irfan; Eryilmaz, Naciye
    Aim: This study aimed to investigate the rate of Panton-Valentine Leukocidin producing Staphylococcus aureus and methicillin (mecA) and slime (icaA/icaD) genes in staphylococcal strains isolated from nasal cavities of footballers. Materials and Methods: Nasal swab samples were taken from each footballers and a healthy control group for the isolation of staphylococcal strains. The polymerase chain reaction technique was used to determine Panton-Valentine Leukocidin, mecA and icaA/icaD genes in staphylococcal isolates. Results: Among 91 S. aureus strains, the presence of mecA gene was detected as 9.9%. This ratio was 17.9% (27 of 151) among the coagulase-negative staphylococci. A significant difference was found between coagulase-negative staphylococci and S. aureus isolates regarding the presence of mecA gene (P < 0.001). As for the genes of the slime, icaA/icaD genes were detected in 198 of 242 (81.8%) strains. The occurrence of slime genes was 91.2% and 89.4% among the S. aureus coagulase and negative staphylococci, respectively (P > 0.05). There was a statistically significant difference between the frequency of the mecA and slime genes when compared with the healthy control group and the football players (P < 0.01). Of 91 isolates, 22 were found to be methicillin resistant by the oxacillin disc diffusion method, whereas the remaining (220) were methicillin susceptible. Methicillin resistance was detected as 14.9% by the polymerase chain reaction method, whereas it was found as 9.1% by phenotypic methods. Conclusions: Early and accurate diagnosis of virulent staphylococcal strains is crucial because the virulent coagulase-negative and coagulase-positive staphylococcal strains in the nasal floras of footballers may be major potential sources of superficial and deep tissue infections.