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Öğe Bibliometric and altmetric analysis of publications examining education methods in realm of anatomy(2021) Petekkaya, Emine; Karadağ, Mehmet; Dokur, MehmetObjectives: This study aimed to investigate the significance of publications examining the effectiveness of education methods in the field of anatomy with the method of bibliometric and altmetric analysis, as well as online attention levels. Methods: To search all publications, “Anatomy education” was entered as a search term on the Web of Science database. The topics, journal impact factors, publication years and research centers of the first 100 articles with the highest numbers of citations were examined, and their analysis was conducted with the “Altmetric it on website: http: almetric.com”. Results: Four thousand, three hundred fifty-six articles published in the period of 1975-2019 containing the key phrase “Anatomy education” were found on Web of Science. The study with the highest number of citations was the study published by McLachlan et al. titled “Teaching anatomy without cadavers, 2004”. It was observed that the study titled “The production of anatomical teaching resources using three-dimensional (3D) printing technology, 2014” was the article with the highest rate of sharing on Twitter with the highest altmetric attention score (AAS) value. The AAS rates varied between 130 and 0. Conclusions: Bibliometric and altmetric analysis provides significant but different points of view regarding the effects of an article in the world of science. The altmetrics score may provide contributions in determining the direction of studies regarding the high-level interests and perceptions of the public on dynamic science and the field of medicine.Öğe Comparative study of the volume of the temporal lobe sections and neuropeptide effect in Alzheimer's patients and healthy persons(Taylor & Francis Ltd, 2021) Petekkaya, Emine; Burakgazi, Gulen; Kus, Berna; Melek, Ismet Murat; Arpaci, AbdullahAim The aim of this study was to make a volumetric comparison of some medial temporal lobe structures and neuropeptides between the patients of Alzheimer's disease (AD) and healthy individuals. Method The study comprised of a group of patients diagnosed with mild AD (n:15) and a Control group (n:15) (16 females, 14 males, mean age:72.90 +/- 4.50). Voxel-based morphometry and MRICloud analyses were performed on the MR images taken in 3D measurements of gray matter volumes of all subjects. Following a 10-minute hug test, blood samples were taken from all participants for oxytocin (OT) and arginine vasopressin (AVP) analyses. Results The patient group had a statistically lower right hippocampus volume (p = 0.004) and OT values (p = 0.028) than the Control group. OT signal values increased with a volume increase in the right parahippocampal gyrus (PHG_R), and OT conc. and AVP conc. values increased with increasing volume of the PHG_R. Conclusion It is suggested that the right hippocampus, right fusiform gyrus, left amygdala, left parahippocampal gyrus, and left entorhinal cortex atrophies can be used as predictors in the early diagnosis of AD. The positive correlation between PHG_R and neuropeptides showed the need to investigate the PHG and OT function more deeply.Öğe Correlation of metal ions with specific brain region volumes in neurodegenerative diseases(Tubitak Scientific & Technological Research Council Turkey, 2023) Melek, Ismet Murat; Kus, Berna; Kaptan, Zulal; Petekkaya, EmineBackground/aim: There are reports stating that deteriorations in metal homeostasis in neurodegenerative diseases promote abnormal protein accumulation. In this study, the serum metal levels in Alzheimer's disease (AD) and Parkinson's disease (PD) and its relationship with the cortical regions of the brain were investigated. Materials and methods: The patients were divided into 3 groups consisting of the AD group, PD group, and healthy control group (n = 15 for each). The volumes of specific brain regions were measured over the participants' 3 -dimensional magnetic resonance images, and they were compared across the groups. Copper, zinc, iron, and ferritin levels in the serums were determined, and their correlations with the brain region volumes were examined. Results: The volumes of left hippocampus and right substantia nigra were lower in the AD and PD groups, while the volume of the left nucleus caudatus (CdN) and bilateral insula were lower in the AD group compared to the control group. Serum zinc levels were lower in the AD and PD groups, while the iron level was lower in the PD group in comparison to the control group. In addition, the serum ferritin level was higher in the AD group than in the control group. Serum zinc and copper levels in the AD group were positively corre-lated with the volumes of the right entorhinal cortex, thalamus, CdN, and insula. Serum zinc and copper levels in the PD group showed a negative correlation with the left nucleus accumbens (NAc), right putamen, and right insula volumes. While the serum ferritin level in the PD group displayed a positive correlation with the bilateral CdN, putamen, and NAc, as well as the right hippocampus and insula volumes, no area was detected that showed a correlation with the serum ferritin level in the AD group. Conclusion: A relationship was determined between the serum metal levels in the AD and PD groups and certain brain cortical regions that showed volumetric changes, which can be important for the early diagnosis of neurodegenerative diseases.Öğe An investigation of olfactory bulb and entorhinal cortex volumesin both patients with Alzheimer’s disease and healthy individuals,and a comparative analysis of neuropeptides(2020) Petekkaya, Emine; Kaptan, Zülal; Ünalmış, Demet; Burakgazi, Gülen; Kuş, Berna; Melek, İsmet Murat; Arpacı, AbdullahAlzheimer’s Disease (AD) is the most common neurodegenerative disease and is hard to diagnose at the early stages. The pathogenesis of AD is associated with the loss of a sense of smell. Reduction in the volumes of the Olfactory Bulb (OB) and Entorhinal Cortex (EC) is positively correlated with the decline of the smelling function where OB projects to EC. This study aims to detect the early changes in OB and EC volumes in AD patients by comparing them to healthy subjects. This study also aims to make a comparative analysis of plasma levels and the relationship between arginine-vasopressin (AVP) and Oxytocin (OT), which are neuropeptides associated with cognitive functions. The participants comprised 9 AD patients and 12 healthy individuals. We used volumetric methods such as MRICloud and IBASPM to measure the OB and EC volumes with the help of 3D MRI (Magnetic Resonance Imaging) images. We compared the left and right differentiation. Moreover, we investigated the neuropeptide levels in blood samples from the participants. We conducted a correlation analysis for all parameters. Bilateral OB atrophy was discovered in the AD patients in comparison to the control group (p=0.002 for right; p=0.015 for left). The right OB volume was measured to be larger than the left OB volume in the control group,but this asymmetry was not observed in the AD patients. The right and left EC's of the AD patients were atrophic in comparison to the control (p<0.001). The atrophy of the left EC was measured to be higher than that of the right EC (p=0.0008). There was no significant difference between the OT and AVP plasma levels of the AD patients and the control group. The study revealed that the OB and EC volumes of the AD patients were bilaterally reduced in comparison to patients of similar ages. This outcome may indicate that an MRI scan examination of OB and EC volumes may help early AD diagnosis.Öğe Possible role of endocannabinoids in olfactory and taste dysfunctions in Alzheimer's and Parkinson's patients and volumetric changes in the brain(Elsevier Sci Ltd, 2022) Petekkaya, Emine; Kus, Berna; Dogan, Serdar; Bayarogullari, Hanifi; Mutlu, Turay; Melek, Ismet Murat; Arpaci, AbdullahThe purpose of this study is to determine the volumes of primary brain regions associated with smell and taste in Alzheimer's and Parkinson's patients and healthy controls using MR imaging and examine volumetric changes in comparison to smell/taste questionnaire and test results and endocannabinoid (EC) levels. The study included 15 AD patients with mild cognitive dysfunction scored as 18 <= MMSE <= 23, 15 PD patients with scores of 18 < MoCA < 26 and 18 <= MMSE <= 23, and 15 healthy controls. A taste and smell questionnaire was given to the participants, and their taste and smell statuses were examined using the Sniffin' Sticks smell identification test and Burghart Taste Strips. EC levels were analyzed in the blood serum samples of the participants using the ELISA method. The volumes of the left olfactory bulb (p = 0.001), left amygdala (p = 0.004), left hippocampus (p = 0.008), and bilateral insula (left p = 0.000, right p = 0.000) were significantly smaller in the Alzheimer's patients than the healthy controls. The volumes of the left olfactory bulb (p = 0.001) and left hippocampus (p = 0.009) were significantly smaller in the Parkinson's patients than the healthy controls. A significant correlation was determined between volume reduction in the left Rolandic operculum cortical region and taste dysfunction. EC levels were significantly higher in both AD (p = 0.000) and PD (p = 0.006) in comparison to the controls. Our results showed that volumetric changes occur in the brain regions associated with smell and taste in Alzheimer's and Parkinson's patients. It was observed that ECs played a role in these volumetric changes and the olfactory and taste dysfunctions of the patients.
