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    Effect of mesalamine on healing in experimental colon anastomosis: A randomised experimental study
    (2008) Aslan, Ahmet; Temiz, Muhyittin; Hakverdi, Sibel; Polat, Gurbuz; Tumer, Cemil; Temiz, Abdulkerim; Canbolant, Elif
    Objective: We aimed to investigate the effect of mesalamine on healing of experimental colon anastomosis model. Material/Methods: Forty adult male Wistar albino rats were performed segmentary colonic resection and end-to-end anastomosis. Animals were randomly divided into four groups: group I, anastomosis group, received no treatment (GI, n = 8); group II, anastomosis + oral mesalamine group (100 mg/kg/day); group III, anastomosis + rectal mesalamine (2 mL) group, (GIII, n = 8); group IV, anastomosis + oral mesalamine + rectal mesalamine (GIV, n = 8) group. A sham group (n = 8) was constituted and was performed laparotomy. Bursting pressure, hydroxyproline levels and histopathological characteristics of the anastomosis were analyzed. Results: Although it was not statistically significant, there was an increase in the burst pressure of the mesalamine group. When hydroxyproline measurements were compared there were statistically significant difference between the non-treated colon and all groups. There were significant differences between GI and GIII-GIV, GII and GIV. The differences between group I and II and group II and III were not statistically significant. When we compared the median amount of the histopathological changes, we found significant difference between the anastomosis and the mesalamine groups (P < 0.05). But when mesalamine groups were compared with each other we did not observe a significant difference. Conclusion: Mesalamine had positive effects which were not statistically significant on bursting pressure and statistically different significant effects on hydroxyproline (HP) levels based on the way of administration and statistically significant positive effects on histopathologic anastomotic healing in experimental anastomosis model. © 2007 Surgical Associates Ltd.
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    Effect of propolis on healing in experimental colon anastomosis in rats
    (Springer, 2008) Temiz, Muhyittin; Aslan, Ahmet; Canbolant, Elif; Hakverdi, Sibel; Polat, Gurbuz; Uzun, Semire; Temiz, Abdulkerim
    Introduction: Propolis is the generic name for the resinous substance collected by honeybees, which is known to have antioxidant, anti-inflammatory, apoptosis-inducible effects. Anastomotic dehiscence after colorectal surgery is an important cause of morbidity and mortality. We aimed to assess the effect of propolis on healing in an experimental colon anastomosis in rats. Methods: Forty adult male Wistar albino rats were randomly assigned into 5 treatment groups with 8 rats in each: Group I, anastomosis+no treatment; Group II, anastomosis+oral propolis ( 600 mg/ kg/ d); Group III, anastomosis+oral ethyl alcohol ( 1 cc/ d); Group IV, anastomosis+rectal propolis ( 600 mg/ kg/ d); Group V, anastomosis+rectal ethyl alcohol ( 1 cc/ d). The bursting pressures, hydroxiproline levels and histopathological changes in each group were measured. Results: When bursting pressures were compared between groups, we observed that they were increased in the groups treated with propolis in contrast to all other groups. Hydroxiproline levels in the propolis groups were also significantly increased in contrast to the other groups. There was also a statistically significant difference in histopathological changes between the treatment types. When propolis administration methods were compared, we did not observe a statistically significant difference. Conclusion: Propolis has a significantly favourable effect on healing in experimental colon anastomosis, independent from the method of administration.
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    Effectiveness of mesalamine and propolis in experimental colitis
    (Springer, 2007) Aslan, Ahmet; Temiz, Muhyittin; Atik, Esin; Polat, Gurbuz; Sahinler, Nuray; Besirov, Eimir; Aban, Nedim
    This study was conducted to investigate the effects of propolis and mesalamine on experimental colitis in rats. Distal colitis was induced in rats by intracolonic instillation of 2 mL of 4% acetic acid. The animals were randomly assigned to 5 groups: group 1, control, (n=8); group 2, colitis, received no treatment (n=8); group 3, colitis+mesalamine, 2 mL once a day via an enema (n=8); group 4, colitis+propolis, 600 mg/kg once a day via intragastric lavage (n=8); and group 5, colitis+ mesalamine+propolis for 1 wk (n=8). Levels of nitric oxide were statistically significantly different in comparisons between groups 1 and 2, groups 2 and 3, and groups 4 and 5. Malondialdehyde levels were significantly different when group 2 was compared with groups 3, 4, and 5. A significant difference was observed when group 3 was compared with group 4 for myeloperoxidase. Most propolis-treated rats had normal histology; mesalamine-treated and propolis+mesalamine-treated rats had inflammatory cell infiltration at rates of 50% and 33%, respectively. The investigators concluded that propolis and mesalamine are efficient independently and in combination, but that their combined effect was not observed to be additive in experimental colitis.