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    The effect of blood glucose regulation on the presence of opportunistic Demodex folliculorum mites in patients with type 2 diabetes mellitus
    (Sage Publications Ltd, 2013) Gokce, Cumali; Aycan-Kaya, Ozlem; Yula, Erkan; Ustun, Ihsan; Yengil, Erhan; Sefil, Fatih; Rizaoglu, Hatice
    Objectives To measure the rate of Demodex folliculorum mite infestation in patients with type 2 diabetes mellitus and to investigate if it was related to blood glucose control. Methods Patients with type 2 diabetes were classified according to their glycosylated haemoglobin (HbA(1c)) level into two groups: a well controlled blood glucose group (HbA(1c)7%) and a poorly controlled blood glucose group (HbA(1c)>7%). A standardized skin surface biopsy method was used to determine if the patients had D. folliculorum infestation (>5 mites/cm(2) of skin). Results A total of 69 patients (38 female) were enrolled in the study. Seventeen (24.6%) patients had D. folliculorum infestation. There were no significant differences in age, sex or body mass index between patients with and without D. folliculorum infestations. A significantly higher proportion of patients with poor blood glucose control had D. folliculorum infestation compared with patients with well controlled blood glucose. Conclusions These current findings suggest that poor blood glucose regulation increases the susceptibility to D. folliculorum mite infestation in patients with type 2 diabetes.
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    Evaluation of mean platelet volume in patients with type 2 diabetes mellitus and blood glucose regulation: a marker for atherosclerosis?
    (E-Century Publishing Corp, 2014) Ulutas, Kemal Turker; Dokuyucu, Recep; Sefil, Fatih; Yengil, Erhan; Sumbul, Ahmet Taner; Rizaoglu, Hatice; Ustun, Ihsan
    Objective: Platelets have an important role in atherosclerosis and arterial thrombosis. Cardiovascular complication prevalence of type 2 diabetes mellitus (type 2 DM) may be associated with glycosylated hemoglobin (HbA(1c)) and mean platelet volume (MPV). The aim of the study was to investigate if platelets were activated in diabetes and its associated vascular complications by measuring the MPV in the diabetics compared to the non-diabetics, and to determine the correlation of MPV with fasting serum glucose (FSG), HbA(1c) and duration of diabetes in the diabetic patients, respectively. Materials and Methods: The study carried out in 65 patients with type 2 DM and 40 non-diabetic subjects. In addition to non-diabetic patients, all diabetic patients were divided into two groups according to their HbA(1c) levels: group A consisted of patients with HbA(1c) levels <= 7% and group B consisted of patients with HbA(1c) levels >7%. Results: MPV was significantly higher in Group B as compared to both non-diabetics and Group A. MPV had a high positive correlation with HbA(1c) and FSG, as with diabetes duration. It is found that MPV was increased in type 2 DM. Conclusion: Our findings suggested an association between MPV and HbA(1c). Therefore, MPV would be a beneficial prognostic marker of cardio-vascular complications in patients with type 2 DM.