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Öğe Association between periodontal diseases and COVID-19 infection: a case-control study with a longitudinal arm(Springer, 2023) Sari, Aysegul; Dikmen, Nursel Kaya; Nibali, LuigiSome studies have suggested potential relationships between periodontal disease and COVID-19, explained by many possible pathological pathways. The aim of this case-control study with a longitudinal arm was to investigate this association. 80 systemically healthy individuals (apart from COVID-19) were involved in this study, divided into 40 patients who had recently had COVID-19 (test, divided into severe and mild/moderate cases) and 40 who had not had COVID-19 (control). Clinical periodontal parameters and laboratory data were recorded. Mann-Whitney U test, Wilcoxon test, and chi-square test were performed to compare variables. Multiple binary logistic regression method was used to estimate adjusted ORs and 95% confidence interval. Hs-CRP-1 and 2, Ferritin-1 and 2, lymphocyte count-1 values, and neutrophil/lymphocyte ratio-1 were higher in patients with severe COVID-19 than patients with mild/moderate COVID-19 (p < 0.05). All of these laboratory values significantly decreased after COVID-19 treatment (p < 0.05) in the test group. Presence of periodontitis (p = 0.015) was higher and periodontal health was lower (p = 0.002) in the test group than in the control group. All clinical periodontal parameters were significantly higher in the test group than in the control group (p < 0.05), except plaque index. Prevalence of periodontitis was associated with increased odds of having COVID-19 infection (PR = 1.34; 95% CI 0.23-2.45) in the multiple binary logistic regression. COVID-19 is associated with periodontitis prevalence, through a series of possible mechanisms including local and systemic inflammatory responses. Further studies should investigate whether the maintenance of periodontal health may be a factor in the reduction of the severity of COVID-19 infections.Öğe Association between periodontal inflamed surface area and serum acute phase biomarkers in patients with sickle cell anemia(Pergamon-Elsevier Science Ltd, 2022) Sari, Aysegul; Ilhan, Gul; Akcali, AliyeObjectives: The aim of the present cross-sectional study was to investigate the association between periodontal inflamed surface area (PISA) and serum inflammatory biomarkers in patients with sickle cell anemia. Design: Patients with sickle cell anemia (n = 80) and systemically healthy individuals (n = 80) were enrolled in the study. Crisis episodes were recorded and blood samples were collected from patients with sickle cell anemia. Clinical periodontal parameters and PISA values were calculated from all patients. Ferritin and high sensitivity C-reactive protein (hs-CRP) levels were analyzed biochemically. Results: In sickle cell anemia group, presence of periodontitis (p < 0.001) was more frequent than periodontal health (p < 0.001). All clinical periodontal recordings and PISA values were higher in the sickle cell anemia group compared to controls (p < 0.001). Patients with PISA > 776 mm(2) had 6.06-fold greater chances of having hs-CRP levels above 10 mg/L (OR = 6.06; 95 % CI: 1.9-19.26) and had 31.41-fold greater chances of having ferritin levels above 1000 ng/L (OR = 31.41; 95 % CI: 6.62-149.16). Also, they had 3.27-fold greater risk of having crisis frequency above three times per year (OR = 3.27; 95 % CI: 1.05-10.23) after adjusting for confounders. Conclusion: In patients with sickle cell anemia, positive association was evident between PISA values and serum acute phase biomarkers levels as well as the frequency of acute painful crisis. Patients with increased inflammatory burden may have a higher likelihood of developing periodontitis in the presence of sickle cell anemia. PISA value could be a candidate disease activity indicator in patients with an underlying hematological condition.Öğe Effect of periodontal disease on oxidative stress markers in patients with atherosclerosis(Springer Heidelberg, 2022) Sari, Aysegul; Davutoglu, Vedat; Bozkurt, Emrullah; Taner, Ibrahim Levent; Erciyas, KamileObjectives The aim of this study was to investigate the effect of periodontal inflammation on oxidative stress in patients with atherosclerosis by considering serum and saliva total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI). Materials and methods In the study, there were 4 groups, with 20 individuals in each group. These groups consisted of individuals who had periodontitis with atherosclerosis (group A-P), were periodontally healthy with atherosclerosis (group A-C), were systemically healthy with periodontitis (group P), and were systemically and periodontally healthy (group C). Clinical periodontal parameters were recorded. PISA values were calculated. Atherosclerosis severity was determined by the Gensini score. The ratio of TAS/TOS resulting in the OSI levels of the serum and saliva samples was examined biochemically. Results Group A-P serum TAS and group C saliva OSI values were lower than those of the other groups (p < 0.05). Group A-P serum TOS and OSI values were higher than those of the other groups (p < 0.05). Groups A-C and P serum TOS and OSI values were higher than those of group C (p < 0.05). In the multivariate linear regression analysis, group A-P and PISA values were independently associated with serum TOS and OSI values (p < 0.05). Group A-P, group P, and PISA values were independently associated with saliva OSI values (p < 0.05). Conclusions Periodontitis and atherosclerosis may have systemic oxidative stress-increasing effects. The coexistence of periodontitis and atherosclerosis increases oxidative stress beyond that seen in either condition alone. Periodontitis can be associated with increased systemic TOS and OSI values in patients with atherosclerosis.Öğe Effect of periodontitis on oxidative stress parameters in patients with rheumatic heart valve disease(Pergamon-Elsevier Science Ltd, 2021) Sari, Aysegul; Davutoglu, Vedat; Bozkurt, Emrullah; Tarakcioglu, Mehmet; Erciyas, KamileObjective: The aim of this study was to evaluate the effects of periodontitis on oxidative stress parameters by investigating serum and gingival crevicular fluid (GCF) total antioxidant capacity (TAOC), total oxidant status (TOS), and oxidative stress index (OSI) values in patients with rheumatic heart valve disease (RHVD). Materials and methods: The study population comprised 76 patients, who were divided into four groups: chronic periodontitis with RVHD (RV-CP), periodontally healthy with RVHD (RV-C), systemically healthy with chronic periodontitis (CP), and systemically and periodontally healthy (C). Demographic, periodontal, and echocardiographic parameters were measured. Serum and GCF oxidative stress parameters were evaluated based on the OSI. Results: Similar serum oxidative stress parameters were found in all study groups (P >= 0.05). The GCF TAOC values of the C group were significantly higher than those of the other groups (P = 0.001). The GCF OSI values of the C group were significantly lower than those of the other groups (P = 0.001). The GCF TOS and OSI values of the RV-CP group were significantly higher than those of the CP and C groups (P = 0.001). The GCF TOS value of the RV-C group was significantly higher than those of the CP and C groups (P = 0.001). Conclusions: Altered local oxidative stress profile was associated with the presence of periodontitis. Rheumatic heart valve disease may increase oxidative stress in individuals with chronic periodontitis.Öğe Effects of Coronavirus (COVID-19) Fear on Oral Health Status(Quintessence Publishing Co Inc, 2021) Sari, Aysegul; Bilmez, Zuhal YildirimPurpose: To investigate the effects of COVID-19 fear on oral health status. Materials and Methods: A total of 1227 participants were enrolled in the study. The online survey link was circulated and responses were received. The questionnaire comprised a total of 24 closed-ended questions, which were divided into three sections. The first section focused on demographic information, the second section on the fear of COVID-19, and the third section focused on oral hygiene habits, dental complaints, and tendency to go to the dentist during the COVID-19 pandemic. Results: Participants who had a higher fear score compared to other respective populations during the corona virus pandemic started brushing more regularly, started to use oral care products more regularly (p = 0.001), and reported increases in: sugary food consumption (p = 0.001), meat consumption (p = 0.017), vegetable consumption (p = 0.019), tooth hypersensitivity, toothache, swelling/abscess on face due to tooth decay (p = 0.001), restoration failures, problems with prostheses (p = 0.007), bleeding and pain in the periodontal tissue, oral malodor, and bruxism (p = 0.001). They also had dental problems but hesitated to visit a dentist, and thought that dental clinics are at risk of COVID-19 contamination (p = 0.001). Conclusion: Fear of COVID-19 was higher in participants who started to pay more attention to their oral hygiene habits, had a change in food consumption frequency and rate, had an increase in oral and dental health complaints, and had dental problems but hesitated to visit a dentist.Öğe Evaluation of IL-23p19/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitis(Springer Heidelberg, 2022) Sari, Aysegul; Dogan, Serdar; Nibali, Luigi; Koseoglu, SerhatObjectives IL-23p19/Ebi3 (IL-39) was described as a new IL-12 family member. The aim of this study is to evaluate the gingival crevicular fluid (GCF) IL-39 levels in periodontal diseases and health and to correlate them to GCF levels of IL-1 beta and periostin. Materials and methods Sixty-six adult patients were included in the study. The study design was comprised of three groups, each containing 22 individuals: the periodontally healthy (PH), gingivitis (G), and periodontitis (P) groups. The clinical periodontal parameters were recorded and GCF samples were collected from the participants. GCF interleukin (IL)-39, IL-1 beta, and periostin levels were examined using the enzyme-linked immunosorbent assay. Results GCF IL-1 beta, periostin, and IL-39 levels were higher in the P and G groups than in the PH group (p < 0.001). Positive correlations were detected between all GCF biochemical parameters and clinical periodontal parameters (p < 0.05). In the multivariate generalized linear regression analysis, the P (beta = 37.6, 95% CI = 22.9-52.4) and G (beta = 28.4, 95% CI = 15.8-41) groups were associated with GCF IL-39 levels (p < 0.001). Conclusion IL-39 levels were elevated in the presence of periodontal disease paralleling the increase in IL-1 beta and periostin levels. IL-39 may have a role in the periodontal inflammation process. Statement of clinical relevance IL-39, a new cytokine from the IL-12 family, can be a possible predictor marker of periodontal diseases.Öğe Periodontal conditions and association of periodontitis with oral-health-related quality of life in patients experiencing different episodes of bipolar disorder compared with healthy controls(Wiley, 2024) Sari, Aysegul; Kokacya, M. Hanifi; Ide, MarkAim: The aim of the present cross-sectional study was to evaluate periodontal conditions and the association of periodontitis with oral-health-related quality of life (OHRQoL) in patients with a history of bipolar disorder.Materials and Methods: A total of 160 participants were recruited in four groups for the study: 40 patients with euthymic episodes, 40 patients with depression, 40 patients with manic episodes and 40 systemically healthy individuals. Clinical periodontal parameters were recorded. Oral Health Impact Profile (OHIP-14) was used to measure the impact of oral health on the quality of life.Results: Bipolar disorder groups exhibited generally higher clinical parameters compared with the control group (p < .05). OHIP-14 total score (beta = 3.32, 95% confidence interval [CI]: 0.08-6.56, p = .044), functional limitation (beta = .89, 95% CI: 0.27-1.49, p = .005) and physical pain (beta = .64, 95% CI: 0.01-1.27, p = .046) were associated with bipolar depression episodes. Psychological discomfort was associated with the presence of generalized periodontitis (beta = .76, 95% CI: 0.01-1.51, p = .047) and psychological disability was associated with the presence of stage III-IV (beta = .83, 95% CI: 0.07-1.59, p = .033) and generalized (beta = .75, 95% CI: 0.07-1.42, p = .029) periodontitis.Conclusions: According to this study, a history of bipolar disorder episodes (exposure) may be associated with increased prevalence and severity of periodontitis and related reported OHRQoL impacts (outcomes). Bipolar depression episodes had a higher impact on OHRQoL than other bipolar episodes.Öğe Periodontal Manifestation in a Patient with Kindler Syndrome(Hindawi Ltd, 2021) Sari, Aysegul; Celik, SalihKindler syndrome is a rare subtype of inherited epidermolysis bullosa. A 42-year-old female patient was admitted to our clinic with a complaint of tooth mobility. Multiple hypo- and hyperpigmented macules dissipated all over her body, prominent poikilodermatous changes, xerosis of the skin, and atrophy were seen in the clinical extraoral examination. Intraoral examination showed atrophy of the buccal mucosa, limited oral opening, epidermal tissue easily separated from the connective tissue, painful ulcers of the hard palate, severe periodontitis, and keratosis of the lips. All of the teeth showed mobility. After dermatologist consultation, the diagnosis of the patient was clinically identified as Kindler syndrome. All of her teeth were extracted due to her progressive periodontal disease and late admission to our clinic. Periodontal treatment might be effective in treating and controlling oral symptoms related to the syndrome and in improving the patient's quality of life.
