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The Effects of Sex Steroids of Endocrine Disrupting Chemicals on Fishes
(Ege Univ, Fac Fisheries, 2010) Cek, Sehriban; Sarihan, Fatmagun
Endocrine disrupting chemicals (EDCs) are anthropogenic compounds that have similar properties as endogenous hormones in vertebrates and they are capable of interfering with the endocrine system. EDCs have been detected in sewage receiving effluents from industries and livestock feedlots. Fish living in the recipients contaminated with these EDCs are reported to have reproductive disabilities. The deleterious effects of EDCs have also been reported in amphibians, reptiles, aves, mammals and humans. The natural estrogen, 17 beta-estradiol (E-2), stimulates the fish liver to synthesize vitellogenin (Vtg). Vtg is the protein that nourishes the maturation of eggs. 17 alpha-ethinylestradiol (EE2) is a potent, synthetic estrogen used in oral contraceptive preparations. It mimics E2 leading to enhanced circulatory Vtg concentrations and male to female sex reversal in fish. 17 beta-trenbolone (Tb), an androgenic steroid, is used as growth promoter in beef cattle. It has been reported to cause declined Vtg concentrations and masculinization in fish. In the near future, many serious problems can be seen in human and wildlife reproduction systems because of EDCs.