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Öğe Dermatoglyphs in patients with psoriasis(Wiley-Blackwell Publishing, Inc, 2010) Dogramaci, A. C.; Yenin, J. Z.; Bagriacik, M. A.; Savas, N.[Abstract Not Available]Öğe Hearing loss in patients with Behcet's disease: an audiological and transient evoked otoacoustic emission study(Cambridge Univ Press, 2010) Aslan, S.; Serarslan, G.; Savas, N.; Teksoz, E.; Dagli, S.Objective: To investigate hearing loss in patients with Behcet's disease. Materials and methods: Twenty-four consecutive cases ofBehqet's disease and 24 sex- and age-inatched controls were included in this study. Pure tone and high frequency audiometric tests were performed and pure tone average hearing thresholds calculated for both groups. Transient evoked otoacoustic emission testing was also performed. Results: Pure tone audiometry showed a sensorineural hearing loss in 15 of the Behcet's disease cars. Hearing thresholds were significantly higher in the study group than in the control group, on both pure tone frequency (except 0.5 kHz) and high frequency audiometry. Significant reductions in transient evoked otoacoustic emission amplitude were found at 1.4 and 2 kHz in the Behcet's disease patients. There were no significant differences in reproducibility, stimulus intensity or stability, comparing the Behcet's disease patients and controls. Conclusion: Significantly lower mid-frequency amplitudes were found in Behcet's patients on transient evoked otoacoustic emission testing.Öğe IMPROVEMENT OF NOCTURNAL ENURESIS AFTER ADENOTONSILLECTOMY IN CHILDREN WITH OBSTRUCTIVE SLEEP APNEA SYNDROME(Elsevier Science Bv, 2010) Goekce, A.; Aslan, S.; Yalcinkaya, F. R.; Davarci, M.; Kaya, Y. S.; Savas, N.; Gorur, S.[Abstract Not Available]Öğe Improvement of nocturnal enuresis after adenotonsillectomy in children with obstructive sleep apnea syndrome(Elsevier Science Bv, 2009) Gokce, A.; Aslan, S.; Yalcinkaya, F. R.; Davarci, M.; Kaya, Y. S.; Savas, N.; Gorur, S.[Abstract Not Available]Öğe Increased macrophage migration inhibitory factor in Behcet's disease and relation with the disease activity(Wiley, 2009) Serarslan, G.; Sogut, S.; Yonden, Z.; Oksuz, H.; Savas, N.; Yenin, J. Z.; Arpaci, A.[Abstract Not Available]Öğe Is androgenetic alopecia a risk for atherosclerosis?(Wiley, 2009) Dogramaci, A. C.; Balci, D. D.; Balci, A.; Karazincir, S.; Savas, N.; Topaloglu, C.; Yalcin, F.Several studies have demonstrated the presence of an association between androgenetic alopecia (AGA) and cardiovascular disease. The aim of this study was to evaluate subclinical atherosclerosis in patients with AGA and healthy controls by the incorporation of carotid intima-media thickness (IMT) and high-sensitive C-reactive protein (hs-CRP) along with echocardiography (ECHO) and exercise electrocardiography (ExECG). We performed a case-control study in 50 male patients with AGA and 31 age-matched healthy male controls with normal hair status. Both the AGA patients and controls with a history of diabetes mellitus, cigarette smoking, hypertension, cardiovascular or cerebrovascular disease, and renal failure were excluded. AGA was classified according to the Hamilton-Norwood scale. Serum lipids, serum hs-CRP, total testosterone, and dehydroepiandrosterone sulphate were examined in all study subjects. Carotid ultrasonography was used to measure the IMT of the common carotid arteries (CCA). ECHO and ExECG were performed in all subjects. IMT of the CCA was found to be significantly higher in patients with severe vertex pattern AGA when compared to patients with other patterns of AGA and healthy controls (P < 0.05). Hs-CRP in patients with any group of AGA was not significantly different from those healthy controls (P > 0.05). ECHO showed that cardiac structural and functional measures were in normal ranges. ExECG was also normal in all subjects. Severe vertex pattern AGA should be considered to have an increased risk of subclinical atherosclerosis. For this reason, CCA IMT measurement can be recommended as a non-invasive and early diagnostic method. None declared.Öğe Is atopy and autoimmunity more prevalent in patients with alopecia areata? A comparative study(Wiley-Blackwell, 2012) Serarslan, G.; Savas, N.; Yenin, J. Z.Objective We aimed to determine whether there was a difference between adult and paediatric alopecia areata patients with respect to the severity and pattern of the disease, nail changes and personal and family history of autoimmune diseases and also in comparison with controls. Methods Two groups were included: patients with onset of alopecia before the age of =18 years and >18 years. The total number of the patients were 124. The control group was comprised of 114 age- and gender-matched patients. Results There were 81 adults and 43 children. No statistically significant difference was present between disease severity and gender, age, personal and family history of autoimmune disease in the adult and paediatric group (P > 0.5). Thirteen adults with scalp involvement had nail changes. 61.5% had mild and 38.46% had severe disease (P > 0.5). Of the 43 paediatric patients, 10 patients had nail changes. Severe alopecia was present in 40% of patients with nail changes; however, 9.1% had severe alopecia in patients without nail changes (P = 0.04). There was no statistical significance in patients with and without familial autoimmune diseases when compared with pattern and severity of the diseases between the two groups. Conclusion The frequencies of autoimmune and atopic diseases were not different between adult and paediatric patients and the control group. We did not find a statistically significance between disease severity and personal and family history of autoimmune disease in the two groups. Disease severity was not related to nail changes in the adult group. However, severe alopecia areata was more prevalent in children with nail changes. Furthermore, ophiasis pattern was more prevalent in the paediatric group with nail changes compared with the adult group.Öğe Macrophage migration inhibitory factor in patients with vitiligo and relationship between duration and clinical type of disease(Wiley, 2010) Serarslan, G.; Yonden, Z.; Sogut, S.; Savas, N.; Celik, E.; Arpaci, A.Background. Vitiligo is a disorder of pigmentation characterized by the presence of depigmented skin macules. Cellular immunity is known to have a role in the pathogenesis of vitiligo. Macrophage migration inhibitory factor (MIF) is a potent activator of macrophages and is considered to play an important role in cell-mediated immunity. Aims. To determine serum level of MIF in patients with vitiligo and compare with healthy controls. We also aimed to determine whether there is a relationship between MIF levels and the disease duration, clinical vitiligo and involved body surface area (BSA) in patients with vitiligo. Methods. The study group comprised 30 patients with vitiligo (14 men, 16 women) and 30 healthy controls, matched for age and gender. Blood samples were taken for MIF analysis. Results. The mean serum level of MIF in patients with vitiligo (40.83 +/- 31.66 pg/mL) was significantly higher than that of the control group (21.00 +/- 6.48 pg/mL) (P = 0.002). There was a positive correlation between disease duration and MIF levels (r = 0.601, P < 0.001). Mean MIF level of patients with acral and acrofacial vitiligo (n = 6) was 48.25 +/- 32.02 pg/mL, and of patients generalized vitiligo (n = 18) was 44.46 +/- 35.25 pg/mL. There was no significant difference between these two groups (P > 0.05). However there was a significant difference in MIF levels between patients with localized (20.41 +/- 5.23, n = 5) and acral-acrofacial (P = 0.02) vitiligo and those with generalized (P = 0.006) vitiligo. There was no relationship between BSA and MIF levels. Conclusions. Mean serum MIF level of patients with vitiligo was higher than that of controls, indicating that MIF has a role in the pathogenesis of vitiligo.Öğe Nosocomial urinary tract infections: Micro-organisms, antibiotic sensitivities and risk factors(Univ West Indies Faculty Medical Sciences, 2006) Savas, L.; Guvel, S.; Onlen, Y.; Savas, N.; Duran, N.Objective. Although urinary tract infections (UTIs) are the most common hospital-acquired infections, the epidemiology of these UTIs is not well defined in Turkey. The aim of this surveillance study was to determine micro-organisms responsible for UTI, their antibiotic sensitivities and to describe the incidence and risk factors of nosocomial urinary tract infections (NUTI). Subjects and Methods: This was a prospective surveillance study including cases of NUTI in intensive care units and various inpatient clinics. This study was carried out between November 2000 and January 2002. The following information was recorded: patients' age, gender type of infection (hospital-acquired), presence of urinary catheter, intensive care unit admission, duration of hospital stay, type of organisms isolated and their antimicrobial susceptibility. The diagnosis of NUTI was based on criteria established by the Centers for Disease Control, Atlanta. Mini Api and conventional culture methods were used to determine the causative agents. The agents were isolated on eosin methylene blue agar and 5% sheep blood agar Statistical analyses of data were by chi-square test and logistic regression. Results: In this study, 618 (2.1%) nosocomial infections (NIs) were determined in 29778 patients, and 178 of these infections were NUTI (28.8%, 178/618). The mean age of NUTI patients was 61.0 +/- 19.4 years (0-91 years) and 82 NUTI patients (46.1%) were male and 96 (53.9%) were female. The most frequently isolated micro-organism was Escherichia coli (31.4%) followed by Candida spp (21.3%), Klebsiella spp (10.6%) and Enterococcus spp (6.9%). Compared to the rate of other NIs, the rate of NUTI increased by 1.011 times per year of age, by 2.052 times in females and by 3.83 times in patients with urinary catheters (p < 0.05). The most effective antibiotics against Gram-negative bacteria were found to be imipenem and meropenem. Conclusions: Important factors to prevent NUTI are to avoid unnecessary urethral catheterization, to choose narrow spectrum antibiotics according to antibiotic sensitivities, to investigate regularly the causative micro-organisms and their resistance patterns and to update the treatment protocols.