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    Graham-Little-Piccardi-Lassueur Syndrome: A Case Report
    (Galenos Yayincilik, 2015) Rifaioglu, Emine Nur; Sen, Tuba; Ozgur, Tumay; Sen, Bilge Bulbul; Ekiz, Ozlem
    A rare type of liken pilanopilaris, Graham-Little-Piccardi-Lassueur syndrome (GLPLS), is characterized by cicatricial alopecia of the scalp, follicular hyperkeratosis of trunk and extremities and non-cicatricial alopecia of axilla and pubis. A forty year-old woman admitted with hair loss and palpabl wheals on her body. On her dermatologic examination alopecic plaques with irregular border and atrophic appearance and milimetric papules around follicules on fronto-parietal part of scalp were detected. Also there were purple like-brown milimetric papules around follicules on both extensor part of distal arm, axilla, upper and lower back with alopecia on hairy areas. Additionally milimetric purplish papules on flexor area of wrists were accompanied to other signs. In histopathological investigation of the biopsy from scalp and back lesions were demonstrated orthokeratosis on superficial layer of epidermis, vacuolar degeneration and exocytosis on basal layer of epidermis and basal layer of follicular epithelium, perifollicular infiltration of mix type inflammatory cells, a few pigmentation deposited macrophages. The patient was diagnosed as GLPLS based on these symptoms and signs. Early diagnosis and treatment of this chronic, progressive characterized, rare type of lichen planopilaris is important. Treatments modalities could stop progression and provide partial remission, although they can't success complete improvement.
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    Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey
    (Soc Brasileira Dermatologia, 2016) Izmirli, Muzeyyen; Sen, Bilge Bulbul; Rifaioglu, Eminenur; Gogebakan, Bulent; Aldemir, Ozgur; Sen, Tuba; Ekiz, Ozlem
    Background: Psoriasis is a multigenic and multifactorial dermatological disease linked to cardiovascular diseases. Increased levels of homocysteine in patients with psoriasis have been demonstrated in many studies. The most frequently investigated genetic defect that plays a role in homocysteine metabolism is single point substitution (C to T) located on the 677th nucleotide of the methylenetetrahydrofolate reductase gene (MTHFR). Objective: In this study, we aimed to investigate methylenetetrahydrofolate C677T polymorphism in psoriasis patients in Turkey. Methods: The study included 96 patients with psoriasis and 77 controls from southern Turkey. Methylenetetrahydrofolate C677T polymorphism was analysed using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism methods. Results: In the psoriasis group, 34 CC (35.4%), 46 CT (47.9%) and 16 TT (16.7%) genotypes were found, respectively; while in the control group, the figures were 39 (50.6%), 35 (45.5%), 3 (3.9%). Homozygote and heterozygote T alleles of methylenetetrahydrofolate C677T polymorphism were significantly higher in the psoriasis than in the control group (p=0.013). Conclusion: We firstly found a correlation between methylenetetrahydrofolate C677T polymorphism and psoriasis among the southern Turkish population.