Yazar "Serarslan, Y." seçeneğine göre listele
Listeleniyor 1 - 11 / 11
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Being a neighbor to Syria: A retrospective analysis of patients brought to our clinic for cranial gunshot wounds in the Syrian civil war(Elsevier Science Bv, 2014) Aras, M.; Altas, M.; Yilmaz, A.; Serarslan, Y.; Yilmaz, N.; Yengil, Erhan; Urfali, B.Objective: Toward the end of 2010, the Arab spring, the waves of revolutionary demonstrations and protests influenced also Syria, where violent clashes turned into a civil war. Hundreds of thousands of people became refugees. The use of excessive force unfortunately culminated in numerous deaths and injuries in many cities. Being the closest city to Aleppo, Damascus and Horns, the biggest cities of Syria, Antioch/Hatay has been the city where initial emergency treatments were performed. For this reason, we examined and retrospectively analyzed the medical records of the patients treated in the clinics of our hospital due to cranial gunshot wounds during the war. Material and methods: The medical records of 186 patients who were injured in the Syrian War and brought to, followed up and treated in the Neurosurgery Clinic of Mustafa Kemal University, Faculty of Medicine in Hatay, a Turkish city on the Syrian border, between April 2011 and June 2013. Results: A total of 186 patients were evaluated in a period of more than 2 years. Of all 91.4% of the patients were adults (male/female: 152/18) and 8.6% of them were pediatric patients (male/female: 14/2). The average age of the patients was 31 years, with an age range of between 2 months and 67 years. According to Glasgow coma score (GCS) of the patients at the time of admission, GCS was 3 in 32 patients (17.2%), between 4 and 7 in 70 patients (37.6%), and between 8 and 15 in 84 patients (45.1%). We observed that the patients with GCS of 4-7 had a significantly lower mortality among the 56 patients treated surgically compared with the 14 patients treated medically. Discussion: Cranial gunshot wounds are responsible for high mortality and morbidity. A multiplicity of factors plays a role on morbidity and mortality. These are the duration of transport, the injury pattern, the velocities of the weapons used, and the Glasgow Coma Scales of the patients at the time of admission. Conclusion: The authors recommend that the patients with cranial gunshot wounds who has GCS of 4-7 should be aggressively treated including surgery as well. We do not recommend surgical treatment for patients with GCS of 3. All our experiences show that treatment of gunshot wounds will continue to be a matter of debate, about which there is more to learn. The data presented in this study will once again demonstrate the seriousness of the event, and will, perhaps, contribute to the peace negotiations to end the war. (C) 2014 Elsevier B.V. All rights reserved.Öğe Congenital (infantile) fibrosarcoma of the scalp: A case report(Springer, 2017) Dogan, E.; Ceylan, E. Cengiz; Gursoy, D.; Secinti, I. E.; Hakverdi, S.; Ozgur, T.; Serarslan, Y.[Abstract Not Available]Öğe Effects of ebselen on ischemia/reperfusion injury in rat brain(Taylor & Francis Ltd, 2014) Aras, M.; Altas, M.; Meydan, S.; Nacar, E.; Karcioglu, M.; Ulutas, K. T.; Serarslan, Y.Aim: Interruption of blood flow may result in considerable tissue damage via ischemia/reperfusion (I/R) injury-induced oxidative stress in brain tissues. The aim of the present study was to investigate the effects of Ebselen treatment in short-term global brain I/R injury in rats. Material and Methods: The study was carried out on 27 Wistar-albino rats, divided into three groups including Sham group (n = 11), I/R group (n = 8) and I/R+Ebselen group (n = 8). Results: Malondialdehyde (MDA) levels were significantly increased in I/R group in comparison with the Sham group and I/R+Ebselen group (p < 0.001 and p < 0.01). Superoxide dismutase (SOD) activity was significantly lower in I/R group in comparison to both Sham (p < 0.001) and I/R+Ebselen (p < 0.01) groups. Similarly, SOD activity was decreased in I/R+Ebselen group when compared with Sham group (p < 0.001). Sham and I/R groups were similar in terms of nitric oxide (NO) levels. In contrast, the NO level was lower in I/R+Ebselen group when compared with Sham (p < 0.001) and I/R (p < 0.01) groups. There was no significant difference among the groups in terms of glutathione peroxidase and catalase activities. In histopathological examination, the brain tissues of rats that received Ebselen showed morphological improvement. Conclusion: Ebselen has neuron-protective effects due to its antioxidant properties as shown by the decrease in MDA overproduction, increase in SOD activity and the histological improvement after administration of Ebselen to I/R in brain tissue.Öğe The effects of mobile phones on apoptosis in cerebral tissue: an experimental study on rats(Verduci Publisher, 2014) Yilmaz, A.; Yilmaz, N.; Serarslan, Y.; Aras, M.; Altas, M.; Ozgur, T.; Sefil, F.INTRODUCTION: The concern about mobile phone effects is increasing as the number of users increasing too. Different studies have different results, so this topic is still open to discussion. Aim of this report was to investigate the effects of the mobile phones on the Bcl-2 gene and p53 proteins in rat brains. MATERIALS AND METHODS: In the study group of 10 rats; mobile phones that spread EMW at a frequency between 1900-2100 MHz and Specific Absorption Rate range between 0.005 W/kg and 0.288 W/kg (Dialing mode), 0.004 W/kg and 0.029 W/kg (Calling mode) were attached to rat ears for simulating usage in daily life for 7 times a day during 5 minutes (3 seconds dialing mode, 4 minutes and 47 seconds of calling mode) for a four week period. Sham group (n=10) rats were only immobilized without EMW exposure. Another group of rats (n=10) were counted as control without any application. immunohistopathological examination was performed for p53 and Bcl-2 expression. RESULTS: Immunohistopathological examinations revealed that the samples in the study group had more p53 and Bcl-2 positive stained cells and they were stained denser. In both evaluations, these differences between the study and control group were found statistically significant (p < 0.003); In Bcl-2 evaluation statistically significant difference was found between study and sham group to (p < 0.005); however, the p53 evaluation between the study and the sham group did not show any statistically significant difference (p > 0.005). CONCLUSIONS: Our results showed that the electro-magnetic waves emitted by the mobile phones may have effect on apoptosis. Besides, obtained data revealed that more realistic application of mobile phones during experiments is more important as expected.Öğe Effects of montelukast and methylprednisolone on experimental spinal cord injury in rats(Verduci Publisher, 2014) Cavus, G.; Altas, M.; Aras, M.; Ozgur, T.; Serarslan, Y.; Yilmaz, N.; Sefil, F.OBJECTIVE: The development of secondary brain injury after trauma is known to involve in many cellular mediators. The aim of the study was to evaluate and compare the effects of the use of both methylprednisolone and montelukast on serum and tissue concentrations of NO, malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity, and tissue glutathione peroxidase (GSH-Px) activity in rats with spinal cord injury (SCI). MATERIALS AND METHODS: SCI was induced in Wistar albino rats by dropping a 10 g rod from a 5.0 cm height at T9-10. The 28 rats were randomly divided into four equal groups: montelukast, methylprednisolone, non-treatment and sham groups. Rats were neurologically tested at 24 hours after trauma and spinal cord tissue levels of MDA, SOD, GSH-PX, CAT levels and blood CK, CK-BB, LDH levels were measured. In addition, histopathological changes were also examined. RESULTS: There was a significant improvement in Tarlov scores in methylprednisolone and montelukast administered group compared to the trauma group (p = 0.001). When compared to trauma group, methylprednisolone and montelukast groups had significant differences in MDA (p < 0.05), SOD (p < 0.001), CK-BB (p < 0.001) and LDH (p < 0.05) levels. Histopathologically, no significant changes were observed. CONCLUSIONS: The present study shows effects of montelukast with biochemical and histopathological parameters and compares its effects with those of methylprednisolone for the first time. Our research has shown that montelukast and methylprednisolone have a neuroprotective effect on spinal cord injury.Öğe Effects of tadalafil on ischemia/reperfusion injury in rat brain(Springer Heidelberg, 2014) Altas, Murat; Aras, M.; Meydan, S.; Nacar, E.; Ulutas, K. T.; Serarslan, Y.; Yilmaz, N.Cerebral ischemia-reperfusion (I/R) injury is caused by lack of blood supply to the brain. The accumulation of toxic products such as reactive oxygen species (ROS) occurs on reperfusion, when the occlusion is removed. The resulting oxidative stress results in the initiation of pathways leading to necrotic and apoptotic cell death. Tadalafil (TAD) prevents the accumulation of ROS and increases antioxidant cellular protective mechanisms. The aim of this study was to investigate the effect of TAD treatment against short-term global brain I/R injury in rats. The study was carried out on 30 Wistar-albino rats, which were divided into three groups including a control group (n = 10), an I/R group (n = 10) and an I/R + TAD group (n = 10) (2 mg/kg/day for 4 days before ischemia). At the end of the experiment, tissue samples were collected for both biochemical and histopathological analyses. Malondialdehyde was significantly lower in the TAD-administered group (9.06 +/- A 0.15) than in the I/R group (p < 0.05). However, no significant difference was observed in nitric oxide levels in the TAD-administered group compared to the I/R group. The mean superoxide dismutase level was significantly higher in the I/R-TAD group than the I/R group. There was no statistically significant difference in glutathione peroxidase levels in I/R + TAD group compared to I/R group. Histopathologically, TAD-administered group provided significant morphological improvement compared to the I/R group. We concluded that TAD prevented I/R-induced neurotoxicity as shown by obtained biochemical and histopathological findings.Öğe An evaluation of brain tumour cases among Syrian refugees in Hatay, Turkey(Springer, 2017) Hakverdi, S.; Secinti, I. E.; Gursoy, D.; Ozgur, T.; Serarslan, Y.; Dogan, E.[Abstract Not Available]Öğe Intracranial benign cystic lesions(Springer, 2017) Secinti, I. E.; Hakverdi, S.; Gursoy, D.; Ozgur, T.; Dogan, E.; Serarslan, Y.[Abstract Not Available]Öğe Intracranial extraaxial anaplastic ependymoma: A rare localisation(Springer, 2017) Secinti, I. E.; Ozgur, T.; Gursoy, D.; Serarslan, Y.[Abstract Not Available]Öğe A medically treated multiple cerebral hydatid cyst disease(Edizioni Minerva Medica, 2010) Altas, M.; Aras, M.; Serarslan, Y.; Davran, R.; Evirgen, O.; Yilmaz, N.Echinococcosis is a potentially fatal parasitic disease that can affect many animals and humans. The disease results from infection by tapeworm larvae of the genus Echinococcus - notably, E. granulosus, E. multilocularis, E vogeli and E. oligarthrus. Cyst hydatid disease is usually seen in adults, and mainly affects liver and/or lungs (90%). Cerebral involvement is very rare (1-3%), and more common in children. Therapy consists of medical treatment and surgical intervention if it is possible. The authors report the case of a 55-year-old male patient with multiple intracranial hydatid cysts, who was successfully treated with albendazole (10 mg/kg/day) alone without any surgical intervention.Öğe Soft micro-balloon paddy for brain retraction in the protection of neuronal tissue(Georg Thieme Verlag Kg, 2006) Serarslan, Y.; Cokluk, C.; Aydin, K.; Iyigun, O.Brain protection is extremely important during arachnoidal dissection and brain separation with a metallic retractor to create a surgical corridor. We have designed a new type of paddy containing air-filled micro-balloons and cotton for use between the metallic retractor and the brain surface for maximal protection of the neuronal tissues from the pressure of the retractor. In neurosurgical operations, cotton paddies are commonly and generally used during the retraction of brain tissue. We hypothesized that air-filled micro-balloon paddies covered with cotton could be helpful in the gentle separation of brain tissue with metallic retractors for minimizing cerebral damage, and for separating sulcal and cisternal walls during brain operations. These paddies are 2 cm in width and 4 cm in length. Multiple air-filled silicon micro-balloons are located in a sheet with 1-2 mm separation from each other. These silicon micro-balloonoid sheets are covered with a cotton sheath. The thickness of this type of paddy is 2-3 mm from the anterior surface to the posterior surface. We used paddies in 86 brain operations where brain retraction was necessary to create a surgical corridor. There was no complication or unwanted events related with the use of these paddies. In conclusion: air-filled silicon micro-balloon,paddies are useful materials for the gentle separation of brain tissue with a metallic retractor in order to minimize cerebral damage, and for the separation of sulcal and cisternal walls during the surgical intervention.
