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  • Küçük Resim
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    İsviçre Esmeri, Holştayn, Simental ve Doğu Anadolu Kırmızısı ırkı ineklerde prob ilaç olarak debrizokin kullanılarak in vivo CYP2D6 enzim aktivitesinin fenotipik belirlenmesi
    (2013) Sakin, Fatih; Baydar, Ersoy; Servi, Kadir; Ateşşahin, Ahmet; Dağoğlu, Gürdal
    Mevcut araştırma; İsviçre Esmeri (İE), Holştayn (HOL), Simental (Sİ) ve Doğu Anadolu Kırmızısı (DAK) ırkı ineklerde prob ilaç olarak debrizokin (DEB) kullanılarak sitokrom P450 2D6 (CYP2D6) enzim aktivitesinin fenotipik belirlenmesi amacıyla yapıldı. Çalışmada her ırktan 15 adet olacak şekilde toplam 60 adet inek kullanıldı. İneklere DEB, 0.5 mg/kg dozunda uygulandı. Uygulamayı takiben 12 ve 24. saatlere kadar çıkarılan idrar örnekleri toplandı. İdrar örneklerinde DEB metabolik oranları (DMO) ve DEB rekoveri oranları (DRO) hesaplandı. 12. saat DMO değerleri DAK ırkı ineklerde diğer ırklara göre anlamlı şekilde yüksek olarak bulunurken (P<0.01), DRO değerleri DAK ırkı ineklerde diğer ırklara göre anlamlı şekilde düşük tespit edildi (P<0.01). DAK ırkı ineklerde CYP2D6 enzim aktivitesinin fenotipi zayıf metabolizer (ZM) olarak değerlendirilirken; İE, HOL ve Sİ ırkı ineklerde ise yaygın metabolizer (YM) olarak değerlendirildi. Sonuç olarak; ineklerde in vivo CYP2D6 enzim aktivitesi fenotipinin belirlenmesinde prob ilaç olarak DEB’in 0.5 mg/kg dozunda uygulandıktan sonra 12. saatte kadar alınan idrar örneklerinin kullanılabileceği ifade edilebilir. Ayrıca, DAK ırkı ineklerde CYP2D6 sübstratı olan ilaçlarla tedavi uygulanmasında bu ilaçların daha yavaş metabolize olacağı, vücutta kalış ve etki sürelerinde artış olacağı sonucuna varılabilir.
  • Küçük Resim
    Öğe
    Phenotyping Determination of in vivo CYP2D6 Enzyme Activity Used as A Probe Debrisoquine in Swiss Black, Holstein, Simmental and Eastern Anatolian Red Cow Breeds
    (Kafkas Univ, Veteriner Fakultesi Dergisi, 2013) Sakin, Fatih; Baydar, Ersoy; Servi, Kadir; Atessahin, Ahmet; Dagoglu, Gurdal
    In the current study was carried out to determine phenotyping of in vivo CYP2D6 enzyme activity used as a probe debrisoquine (DEB) in Swiss Black (SB), Holstein (HOL), Simmental (SI) and Eastern Anatolian Red (EAR) cows. In the study, totally 60 cows, fifteen cows from each breed, were used. DEB was application at 0.5 mg/kg. Urine samples were collected throughout 12. and 24th h after DEB application. The metabolic (DMR) and recovery (DRR) rates of DEB in urine samples were calculated to evaluate the in vivo activity of CYP2D6 enzyme activity. The DMR value of EAR at 12th h were significantly higher than those others (P<0.01) while this value significantly lower in EAR compared to that of others (P<0.01). The phenotyping CYP2D6 enzyme activity of EAR at 12th h was considered as poor metaboliser (PM) while this phenotype was extensive metabolizer (EM) in SB, HOL and SI cows. In conclusion, it can be considered that urine samples taken at 12th h after DEB administration at dose of 0.5 mg/kg as probe can be used to determine in vivo phenotyping of CYP2D6 enzyme activity in cows. Besides, in implementation of treatment with drugs that are substrates of CYP2D6 in cows, it can be concluded that these drugs will be metabolized more slowly, and the duration time of body and effect durations of action will be increased in EAR cows.
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    Öğe
    THE PROTECT WE EFFECTS OF LYCOPENE ON THE LOSS OF BODY WEIGHT AND HISTOPATHOLOGICAL LESIONS IN LIVER, KIDNEY, HEART, AND BRAIN TISSUE OF RATS EXPOSED TO SUBCHRONICALLY DIFFERENTIAL DOSES OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN
    (Soc Stinte Farmaceutice Romania, 2011) Sakin, Fatih; Ceribasi, Ali Osman; Servi, Kadir; Lacramioara, Popa
    The aim of this study was to investigate the possible protective role of lycopene (LYC) on body weight changes, and histopathological lesions on liver, kidney, heart, and brain tissue in male rats exposed to subchronically differential doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a highly toxic xenobiotic. Forty-eight rats were divided into six groups. The first group received 0.5 mL corn oil as control; the second group was treated with 10 mg/kg bw/day LYC. Groups 3 and 4 were treated with 50 and 500 ng/kg bw/day of TCDD, respectively. Groups 5 and 6 were subjected to 50 and 500 ng/kg bw/day of TCDD along with 10 mg/kg bw/day of LYC, simultaneously. The period of the experiment was 13 weeks. In TCDD-treated groups, a dose-related depression of mean body weight was observed when compared to control. Simultaneously LYC administration reduced the loss of body weight and partially or totally recovered the formed histopathological lesions in liver, kidney, and heart tissue of rats exposed to TCDD. As a result, it is suggested that LYC has a protective effect against the loss of body weight and toxicity caused by TCDD.
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    Öğe
    PROTECTIVE EFFECT OF LYCOPENE ON OXIDATIVE STRESS INDUCED BY DIFFERENT DOSES OF 2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN IN BRAIN, LIVER, KIDNEY, AND HEART TISSUE OF RATS
    (Soc Stiinte Farmaceutice Romania, 2011) Sakin, Fatih; Bulmus, Funda Gulcu; Servi, Kadir; Popa, Lacramioara
    The aim of this study was to investigate the possible protective role of lycopene (LYC) on liver, kidney, heart, and brain in male rats exposed to different doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Forty-eight rats were divided into six groups. The first group received 0.5 mL corn oil as control; the second group was treated with 10 mg/kg bw/day LYC. Groups 3 and 4 were treated to 50 and 500 ng/kg bw/day of TCDD, respectively. Groups 5 and 6 were subjected to 50 and 500 ng/kg bw/day of TCDD along with 10 mg/kg bw/day of LYC, simultaneously. The duration of the experiment was 13 weeks. While the exposure to TCDD increased the levels of malondialdehyde (MDA), it decreased glutathione (GSH) levels, and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities. However, LYC-treatment decreased the high MDA levels and increased GSH, SOD, GSH-Px, and CAT activities. In conclusion, LYC treatment decreased TCDD-induced lipid peroxidation and supported the antioxidant activity. It is suggested that LYC has a protective effect against oxidative stress induced by TCDD.
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    Öğe
    Protective effect of lycopene on oxidative stress induced by different doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin in brain, liver, kidney, and heart tissue of rats
    (2011) Sakin, Fatih; Bulmuş, Funda Gülcü; Servi, Kadir; Popa, Lacramioara
    The aim of this study was to investigate the possible protective role of lycopene (LYC) on liver, kidney, heart, and brain in male rats exposed to different doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Forty-eight rats were divided into six groups. The first group received 0.5 mL corn oil as control; the second group was treated with 10 mg/kg bw/day LYC. Groups 3 and 4 were treated to 50 and 500 ng/kg bw/day of TCDD, respectively. Groups 5 and 6 were subjected to 50 and 500 ng/kg bw/day of TCDD along with 10 mg/kg bw/day of LYC, simultaneously. The duration of the experiment was 13 weeks. While the exposure to TCDD increased the levels of malondialdehyde (MDA), it decreased glutathione (GSH) levels, and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities. However, LYC-treatment decreased the high MDA levels and increased GSH, SOD, GSH-Px, and CAT activities. In conclusion, LYC treatment decreased TCDD-induced lipid peroxidation and supported the antioxidant activity. It is suggested that LYC has a protective effect against oxidative stress induced by TCDD.
  • Küçük Resim
    Öğe
    Protective effects of curcumin on antioxidant status, body weight gain, and reproductive parameters in male rats exposed to subchronic 2,3,7,8-tetrachlorodibenzo-p-dioxin
    (Taylor & Francis Ltd, 2013) Bulmus, Funda Gulcu; Sakin, Fatih; Turk, Gaffari; Sonmez, Mustafa; Servi, Kadir
    The aim of this study was to investigate the effects of curcumin (CUR) on antioxidant status, body weight (BW) gains, and some reproductive parameters in male rats exposed to subchronic doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Thirty-two rats were divided into four groups. The first group was kept as control. The second group (TCDD group) was given TCDD at a dose of 50ngkg(-1) BW per day; the third group (CUR group) was treated with CUR at a dose of 80mgkg(-1) BW per day. The fourth group (TCDD + CUR group) was given TCDD and CUR at the same doses simultaneously. Malondialdehyde (MDA) levels were significantly increased in the TCDD group. In addition, TCDD exposure decreased liver superoxide dismutase (SOD) activity, catalase (CAT) activities of kidney and brain, glutathione peroxidase (GSH-Px) activities of liver, kidney, and brain, and glutathione levels of liver, kidney, and heart. However, CUR treatment with TCDD exposure decreased MDA levels in all tissues and increased SOD activities of liver, kidney, and brain, CAT activity of heart, and GSH-Px activities of heart and brain. TCDD caused a decrease in BW gain, and CUR partially eliminated this effect of TCDD. In addition, while reproductive organ weights, sperm concentration, and sperm motility tended to decrease with TCDD exposure, these effects tended to be close to normal levels by CUR treatment. In conclusion, CUR was seen to be effective in the treatment and prevention of toxicity induced by subchronic TCDD exposure.
  • [ N/A ]
    Öğe
    The protective effects of lycopene on the loss of body weight and histopathological lesions in liver, kidney, heart, and brain tissue of rats exposed to subchronically differential doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin
    (2011) Sakin, Fatih; Çeribaşi, Ali Osman; Servi, Kadir; L?cr?mioara, Popa
    The aim of this study was to investigate the possible protective role of lycopene (LYC) on body weight changes, and histopathological lesions on liver, kidney, heart, and brain tissue in male rats exposed to subchronically differential doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a highly toxic xenobiotic. Forty-eight rats were divided into six groups. The first group received 0.5 mL corn oil as control; the second group was treated with10 mg/kg bw/day LYC. Groups 3 and 4 were treated with 50 and 500 ng/kg bw/day of TCDD, respectively. Groups 5 and 6 were subjected to 50 and 500 ng/kg bw/day of TCDD along with 10 mg/kg bw/day of LYC, simultaneously. The period of the experiment was 13 weeks. In TCDD-treated groups, a dose-related depression of mean body weight was observed when compared to control. Simultaneously LYC administration reduced the loss of body weight and partially or totally recovered the formed histopathological lesions in liver, kidney, and heart tissue of rats exposed to TCDD. As a result, it is suggested that LYC has a protective effect against the loss of body weight and toxicity caused by TCDD.